Navigation Links
Scripps Florida scientist awarded $3.4 million for HIV/AIDS research
Date:11/30/2011

JUPITER, FL -- A scientist at The Scripps Research Institute has been awarded $3.4 million from the National Institutes of Health to study the mode of action and the therapeutic potential of a new compound that blocks a step of HIV replication not targeted by current therapies.

Susana Valente, an assistant professor at Scripps Florida, is the principal investigator of the five-year grant. Valente will lead research into the viral protein known as Tat, a potent activator of HIV gene expression, and a Tat inhibitor that is extremely effective at reducing viral output from acutely and chronically infected cells in culture. Most antiretroviral compounds only block new infections; a Tat inhibitor can reduce viral replication from cells already infected.

"Our main goal with this grant is to fully understand the underlying mechanism of this new compound's inhibitory strength against Tat," Valente said, "and then to evaluate its therapeutic potential in animal models. If that's successful, the next obvious step would be to optimize it for use in human clinical trials."

Despite recent advances, HIV/AIDS continues its deadly global march, affecting more than 35 million individuals worldwide. The virus stubbornly persists in infected subjects despite Highly Active Antiretroviral Therapy (HAART). This residual viremia is the major hurdle for HIV eradication. Valente's newly identified Tat inhibitor defines a novel class of anti-viral drugs that could potentially inhibit viral production from stable reservoirs and reduce viral persistency during HAART.

"Initially, we though this compound was targeting another protein, but the data suggested that it was actually an inhibitor of Tat," Valente said. "We soon discovered we had a powerful inhibitor of HIV-1 transcription in our handsand that's where we are today. This work was made possible by the great ongoing collaboration with Professor Phil Baran of Scripps California."


'/>"/>
Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Page: 1

Related biology news :

1. Scripps Research scientists uncover new role for gene in maintaining steady weight
2. Scripps Research team finds a weak spot on deadly ebolavirus
3. Scripps research scientists develop brand new class of small molecules through innovative chemistry
4. Scripps Health/the Medicines Company announce late breaking BRIDGE trial results presented at TCT
5. Scripps research team achieves critical step to opening elusive class of compounds to drug discovery
6. Scripps Research scientist awarded $500,000 grant to study Parkinsons disease
7. Scripps launches whole genome sequencing study to find root causes of idiopathic diseases
8. Scripps and Complete Genomics to collaborate on genetic research study on healthy aging
9. 2 Scripps Research scientists win prestigious NIH Innovator Awards
10. Scripps Research team overcomes major obstacle for stem cell therapies and research
11. Scripps Research scientists pinpoint shape-shifting mechanism critical to protein signaling
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scripps Florida scientist awarded $3.4 million for HIV/AIDS research
(Date:4/13/2015)...  higi, a leading cloud-based consumer engagement platform that ... with their communities around health and wellness, announced today ... API.  ... and convenient vehicle to receive validated health information from ... The API will allow higi,s trusted partners, on a ...
(Date:4/6/2015)... OXFORD, Conn. , Apr. 6, 2015 /PRNewswire/ ... the "Company"), a biometric authentication company focused on ... it has filed provisional patent 62/143028 for ... CLOSE-PROXIMITY COMMUNICATIONS AND ENERGY TRANSFER  NXT-ID introduces ... wireless payments. This patent surrounds the use of ...
(Date:4/2/2015)... 2, 2015 Fingerprint Cards (FPC) ... FPC1025 from the distributor World Peace Industrial Group (WPI), ... 2015 although the major part of the shipments will ... used by smartphone manufacturers in China ... in the communicated revenue guidance of + 1 000 MSEK ...
Breaking Biology News(10 mins):higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 4Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 110 Million 2
... Scientists using tiny particles of genetic material to interfere ... have successfully prevented monkeys exposed to that virus from ... this week,s issue of The Lancet , suggests ... "Over the past decade, we have evaluated numerous ...
... host a round-the-clock, robotically choreographed hunt for carbon-hungry materials. ... diverse team of scientists whose goal is to quickly ... a power plant,s exhaust, before it leaves the smokestack ... a recently discovered class of materials called metal-organic frameworks ...
... oxide-based nanoparticles, a research team working at the National ... one. But once its implications are understood, their discovery* ... The nanoparticles in question are spheres of magnetite so ... would stretch a hair,s width, and they have potential ...
Cached Biology News:Experimental treatment protects monkeys from lethal Ebola virus post-exposure 2Experimental treatment protects monkeys from lethal Ebola virus post-exposure 3The search for improved carbon sponges picks up speed 2The search for improved carbon sponges picks up speed 3NIST scientists gain new 'core' understanding of nanoparticles 2
(Date:4/23/2015)... (PRWEB) April 23, 2015 ... refer to a series of genetic tests that ... fibrosis, Lou Gehrig's disease, Huntington's disease, and Alzheimer's ... the gene composition and interaction in diseased tissue/cells ... as well as the response to treatment, such ...
(Date:4/23/2015)... Proove Biosciences , a ... excited to announce the launch of Proove ... assesses 62 genetic variations to predict good versus ... prescribed non-opioid pain medications, namely ibuprofen (brand name ... name Xanax) and acetaminophen (brand name Tylenol). ...
(Date:4/23/2015)... CA (PRWEB) April 23, 2015 Delpor, ... today announced that the United States Patent and Trademark ... Company’s NANOPOR™ technology. US Pat. No. ... Delpor’s microfabricated drug delivery device for the ... proprietary NANOPOR™ technology for the sustained (zero-order) release of ...
(Date:4/22/2015)... Wilmington, Del. (PRWEB) April 22, 2015 ... acquire Taxon Biosciences, Inc., a leading microbiome discovery ... capabilities and unparalleled market access in both seed ... solutions for agriculture customers globally. , “In ... Health and Industrial Biosciences segments sold more than ...
Breaking Biology Technology:Increasing Disease Prevalence & Focus on Preventive Healthcare Drive the Predictive Diagnostics Market, According to a New Report by Global Industry Analysts, Inc. 2Increasing Disease Prevalence & Focus on Preventive Healthcare Drive the Predictive Diagnostics Market, According to a New Report by Global Industry Analysts, Inc. 3Proove Biosciences Launches World’s First Test to Predict Responders to Commonly Prescribed Non-Opioid Pain Medications 2Proove Biosciences Launches World’s First Test to Predict Responders to Commonly Prescribed Non-Opioid Pain Medications 3Delpor, Inc. Announces the Issuance of 2 New US Patents Based on its Nanopore Technology which Enables the Sustained Release of Drugs from a Small Implant Device 2Delpor, Inc. Announces the Issuance of 2 New US Patents Based on its Nanopore Technology which Enables the Sustained Release of Drugs from a Small Implant Device 3DuPont Acquires Taxon Biosciences, Inc. 2DuPont Acquires Taxon Biosciences, Inc. 3DuPont Acquires Taxon Biosciences, Inc. 4
... with Multiple Disparate PACS and RIS Systems ... ... Nov. 26 RSNA Booth #5924 -- Compressus Inc.,makers ... diagnostic acquisition devices, PACS, HIS, RIS,and related information systems, ...
... Medical,Innovations, Inc. (AMEX: IMA ) today announced ... acquire ParadigmHealth, Inc. ParadigmHealth,headquartered in New Jersey, is ... management services for acutely ill and clinically complex,patients, ... Commenting on the agreement, Ron Zwanziger, CEO of ...
... Reduces Duplicative and Unnecessary Incidentaloma Exams Through Access ... ... Booth #5924 -- Compressus Inc.,and Advanced Radiology Consultants, S.C. (ARC), ... has improved physician,efficiency and patient safety, reduced unnecessary and duplicative ...
Cached Biology Technology:E-Rad Solutions Selects Compressus' Enterprise Systems Integration Technology to Fuel Entry Into Teleradiology Market 2E-Rad Solutions Selects Compressus' Enterprise Systems Integration Technology to Fuel Entry Into Teleradiology Market 3Inverness Medical Innovations Agrees to Acquire ParadigmHealth 2Inverness Medical Innovations Agrees to Acquire ParadigmHealth 3Diagnostic Turnaround Improved by 600% Through Interoperability 2Diagnostic Turnaround Improved by 600% Through Interoperability 3Diagnostic Turnaround Improved by 600% Through Interoperability 4
... The lyophilization stabilizer is designed to ... and for long-term storage. There ... ingredients. It is a convenient ... 7.2, and is superior to other ...
... The CERTOMAT IS, a true benchtop incubator-shaker, has ... Having a footprint of 540 x 680 ... large incubation chamber (370 x 505 x 510mm). ... the CERTOMAT IS is ideal for shaking applications ...
... TC-3000 is one of the smallest thermal cyclers ... choice of either the 0.5ml (20 samples) or ... , Fast heating and cooling rate of ... and high performance Fast track programming with ...
... StabilZyme HRP Conjugate Stabilizer is an aqueous ... and other non-toxic stabilizing chemicals in a ... 6.7. This product contains a ... 20 ppm Proclin 300 (Rohm and Haas ...
Biology Products: