Navigation Links
Scripps Florida scientist awarded $3.4 million for HIV/AIDS research
Date:11/30/2011

JUPITER, FL -- A scientist at The Scripps Research Institute has been awarded $3.4 million from the National Institutes of Health to study the mode of action and the therapeutic potential of a new compound that blocks a step of HIV replication not targeted by current therapies.

Susana Valente, an assistant professor at Scripps Florida, is the principal investigator of the five-year grant. Valente will lead research into the viral protein known as Tat, a potent activator of HIV gene expression, and a Tat inhibitor that is extremely effective at reducing viral output from acutely and chronically infected cells in culture. Most antiretroviral compounds only block new infections; a Tat inhibitor can reduce viral replication from cells already infected.

"Our main goal with this grant is to fully understand the underlying mechanism of this new compound's inhibitory strength against Tat," Valente said, "and then to evaluate its therapeutic potential in animal models. If that's successful, the next obvious step would be to optimize it for use in human clinical trials."

Despite recent advances, HIV/AIDS continues its deadly global march, affecting more than 35 million individuals worldwide. The virus stubbornly persists in infected subjects despite Highly Active Antiretroviral Therapy (HAART). This residual viremia is the major hurdle for HIV eradication. Valente's newly identified Tat inhibitor defines a novel class of anti-viral drugs that could potentially inhibit viral production from stable reservoirs and reduce viral persistency during HAART.

"Initially, we though this compound was targeting another protein, but the data suggested that it was actually an inhibitor of Tat," Valente said. "We soon discovered we had a powerful inhibitor of HIV-1 transcription in our handsand that's where we are today. This work was made possible by the great ongoing collaboration with Professor Phil Baran of Scripps California."


'/>"/>
Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Page: 1

Related biology news :

1. Scripps Research scientists uncover new role for gene in maintaining steady weight
2. Scripps Research team finds a weak spot on deadly ebolavirus
3. Scripps research scientists develop brand new class of small molecules through innovative chemistry
4. Scripps Health/the Medicines Company announce late breaking BRIDGE trial results presented at TCT
5. Scripps research team achieves critical step to opening elusive class of compounds to drug discovery
6. Scripps Research scientist awarded $500,000 grant to study Parkinsons disease
7. Scripps launches whole genome sequencing study to find root causes of idiopathic diseases
8. Scripps and Complete Genomics to collaborate on genetic research study on healthy aging
9. 2 Scripps Research scientists win prestigious NIH Innovator Awards
10. Scripps Research team overcomes major obstacle for stem cell therapies and research
11. Scripps Research scientists pinpoint shape-shifting mechanism critical to protein signaling
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scripps Florida scientist awarded $3.4 million for HIV/AIDS research
(Date:5/9/2016)... UAE, May 9, 2016 Elevay ... comes to expanding freedom for high net worth professionals ... in today,s globally connected world, there is still no ... could ever duplicate sealing your deal with a firm ... passports by taking advantage of citizenship via investment programs ...
(Date:4/26/2016)... -- Research and Markets has announced the ...  report to their offering.  , ,     (Logo: ... forecast the global multimodal biometrics market to grow ... 2016-2020.  Multimodal biometrics is being implemented ... healthcare, BFSI, transportation, automotive, and government for controlling ...
(Date:4/13/2016)...  IMPOWER physicians supporting Medicaid patients in ... standard in telehealth thanks to a new partnership with ... IMPOWER patients can routinely track key health measurements, such ... and, when they opt in, share them with IMPOWER ... local retail location at no cost. By leveraging this ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... 27, 2016 /PRNewswire/ - BIOREM Inc. (TSX-V: BRM) ("Biorem" or ... its major shareholders, Clean Technology Fund I, LP and ... based venture capital funds which together hold ... a fully diluted, as converted basis), that they have ... entire equity holdings in Biorem to TUS Holdings Co. ...
(Date:6/27/2016)... ... June 27, 2016 , ... Newly created 4Sight ... solutions to the healthcare market. The company's primary focus is on new product ... marketing strategies that are necessary to help companies efficiently bring their products to ...
(Date:6/24/2016)...  Regular discussions on a range of subjects including policies, ... entities said Poloz. Speaking at a lecture to ... he pointed to the country,s inflation target, which is set ... "In certain areas there needs ... economic goals, why not sit down and address strategy together?" ...
(Date:6/23/2016)... ... June 23, 2016 , ... Mosio, a leader in clinical ... Patient Recruitment and Retention Tips.” Partnering with experienced clinical research professionals, Mosio revisits ... tips, tools, and strategies for clinical researchers. , “The landscape of how patients ...
Breaking Biology Technology: