Navigation Links
Scientists win $2 million grant to study impact of early nutrition on lifespan
Date:5/21/2014

JUPITER, FL, May 21, 2014 Scientists from the Florida campus of The Scripps Research Institute (TSRI) have been awarded a $2 million grant from the National Institute on Aging of the National Institutes of Health to study the effects of early nutrition on lifespan and overall health.

William Ja, a TSRI assistant professor, is the principal investigator for the five-year study.

During critical periods of growth and development, particularly during early stages of life, animals are highly sensitive to nutritionor lack of itand modify their metabolism accordingly. This "nutritional-priming" phenomenon causes physiological changes that can persist throughout life and can have a marked impact on life-long health.

In humans, imbalanced nutrition during early childhood greatly influences future health and development, and poor diets during early growth periods can increase the likelihood of developing obesity, diabetes and heart disease in later life.

"This study will provide new strategies to develop drug candidates that could reverse the effects of a poor early dietand that have the potential to improve human healthspan," Ja said.

In addition, he noted, the cellular mechanisms underlying the effects of early diet on metabolism and aging have been largely unexplored. Unraveling those fundamental mechanisms are a primary aim of the new study.

Because multiyear, longitudinal studiesresearch done on a single group of individuals over an extended period of timecan be costly and difficult, Ja and his colleagues will first tackle the problem using the fruit fly, Drosophila melanogaster, a reliable and commonly used model, to investigate the role of early nutrition on lifespan and overall health.

"How poor nutrition affects aging is difficult to test in humans," said Kimberley Bruce, a postdoctoral associate in the Ja laboratory who will spearhead the study. "But fruit flies live 80 days rather than 80 years, so we can rapidly see how different diets alter lifespan."

For example, preliminary data generated by TSRI graduate student Sany Hoxha showed that even a brief exposure to a high-protein diet during early adulthooda critical period of both fly and human developmentreduces lifespan compared to animals fed a low protein diet during the same period.

"Protein stimulates the same aging pathways in flies as in humans," Bruce added. "It has not been well studied, but we think excessive protein intake in early life may also have a negative effect on human aging."

The number of the grant is 1R01AG045036-01A1.
'/>"/>

Contact: Eric Sauter
esauter@scripps.edu
267-337-3859
Scripps Research Institute
Source:Eurekalert  

Related biology news :

1. Stanford scientists develop gene therapy approach to grow blood vessels in ischemic limbs
2. Queens scientists seek vaccine for Pseudomonas infection
3. Scientists produce eye structures from human blood-derived stem cells
4. American Society of Plant Biologists honors early career women scientists
5. Brandeis scientists win prestigious prize for circadian rhythms research
6. Scientists discover new method of proton transfer
7. Salk scientists open new window into how cancers override cellular growth controls
8. WileyChina.com - Now Featuring Bespoke Pages for China’s Life Scientists
9. Scientists win $2 million to study new pathway in development and maintenance of lymphoma
10. UGA scientists reveal genetic mutation depicted in van Goghs sunflower paintings
11. Genetic mutation depicted in van Goghs sunflower paintings revealed by scientists
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists win $2 million grant to study impact of early nutrition on lifespan
(Date:2/16/2017)... , Feb. 16, 2017  Genos, a community ... that it has received Laboratory Accreditation from the ... is presented to laboratories that meet stringent requirements ... scientifically rigorous processes. "Genos is committed ... laboratory practices. We,re honored to be receiving CAP ...
(Date:2/10/2017)... 10, 2017 Research and Markets ... "Personalized Medicine - Scientific and Commercial Aspects" to their ... ... is integrated with therapy for selection of treatment as well ... and prevention of disease in modern medicine. Biochip/microarray technologies and ...
(Date:2/8/2017)... Report Highlights ... The global synthetic-biology market reached nearly $3.9 billion in ... a compound annual growth rate (CAGR) of 24.0% through 2021. ... for synthetic biology. - Analyses of global market trends, with ... annual growth rates (CAGRs) through 2021. - Coverage of core ...
Breaking Biology News(10 mins):
(Date:2/24/2017)... 24, 2017  OncoSec Medical Incorporated ("OncoSec") (NASDAQ: ONCS), ... a Key Opinion Leader event to highlight new clinical ... poster presentation at the upcoming 2017 ASCO-SITC Immuno-Oncology Symposium ... will be held in-person and via live webcast on ... AM PST at the Lotte New York Palace Hotel ...
(Date:2/23/2017)... , Feb. 23, 2017  MIODx announced today ... two key immunotherapy technologies from the University of ... a method to monitor a patient for response ... and CTLA-4.  The second license extends the technology ... is likely to have an immune-related adverse event ...
(Date:2/23/2017)... (PRWEB) , ... February 23, ... ... Inc., announced today that in a published evaluation of multiple immunoassay-based threat ... U.S. Department of Energy Laboratory, PathSensors’ CANARY® biosensor threat detection technology was ...
(Date:2/23/2017)... , Feb. 23, 2017 Aviva Systems ... announced the acquisition of GenWay Biotech Incorporated, a ... service and product offering for both the research ... facilitate growth and enhance capabilities for both entities. GenWay,s ... ELISA assays will nicely complement ASB,s objective to ...
Breaking Biology Technology: