Navigation Links
Scientists use worms to unearth cancer drug targets
Date:8/9/2012

BETHESDA, MD August 9, 2012 -- Through novel experiments involving small nematode worms, scientists from Wyoming have discovered several genes that may be potential targets for drug development in the ongoing war against cancer. Specifically, researchers hypothesize that inhibiting these genes could reverse certain key traits associated with cancer cells. This discovery is published in the August 2012 issue of the Genetics Society of America's journal GENETICS (www.genetics.org).

"Cancer is a leading cause of death worldwide," said David S. Fay, Ph.D., a researcher involved in the work from the Molecular Biology Department at the University of Wyoming in Laramie. "We hope that by carrying out basic genetic research on one of the most widely implicated human cancer genes, that we can contribute to the arsenal of diverse therapeutic approaches used to treat and cure many types of cancer."

To make this discovery, Dr. Fay and his colleagues used a strain of nematode worms that carried a mutation in a gene similar to one that is inactivated in many human cancers. This gene, called "LIN-35" in worms and "pRb" in humans, is thought to control at least several aspects of tumor progression including cancer cell growth and survival. The researchers systematically inactivated other individual genes in the genome of the mutant LIN-35 worms. As they deactivated various genes, scientists identified those that led to a reversal of defects caused by the loss of LIN-35, suggesting that they could be used as targets for anti-cancer therapies.

"This research is important because it offers possible new ways to shut down the genetic machinery that contributes to cancer growth and progression," said Mark Johnston, Ph.D., Editor-in-Chief of the journal GENETICS. "The causes of cancer are complex and varied, so we must approach this disease from many angles. Using simple 'model organ
'/>"/>

Contact: Phyllis Edelman
pedelman@genetics-gsa.org
301-634-7302
Genetics Society of America
Source:Eurekalert

Page: 1 2

Related biology news :

1. Composite nanofibers developed by Penn scientists next chapter in orthopaedic biomaterials
2. Scientists define new limits of microbial life in undersea volcanoes
3. Farmers team with scientists to make the perfect rat trap
4. Scientists discover molecular link between circadian clock disturbances and inflammatory diseases
5. UTMB scientists awarded NIH grant for lab-grown lung tissue project
6. WHOI scientists/engineers partner with companies to market revolutionary new instruments
7. Stanford-Penn State scientists use microbes to make clean methane
8. Citizen scientists needed for SF States ZomBee Watch
9. Scientists confirm existence of vitamin deserts in the ocean
10. MBL scientists to explore hidden realm of microbes, viruses beneath the ocean floor
11. Scientists connect seawater chemistry with climate change and evolution
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... Salk Institute for Biological Studies, BGI, and other ... and reliability of the existing targeted gene correction ... which could significantly increased gene-correction efficiency in human ... online in Cell Stell Cell provides ... therapy. , The combination of stem cells and ...
(Date:7/11/2014)... July 11, 2014 Researchers have pioneered ... images. The new technology, called Virtual Finger, allows ... structures like neurons and synapses using the flat ... technology makes 3D imaging studies orders of magnitude ... an unprecedented level across many areas of experimental ...
(Date:7/11/2014)... the normal circumstances, astrocytes participate in normal ... and exhibit therapeutic and repairing effects on ... have found that nerve cells differentiated from ... reduced viability, which produces influences on subsequent ... General Hospital, Hebei United University, China demonstrated ...
Breaking Biology News(10 mins):A new genome editing method brings the possibility of gene therapies closer to reality 2Virtual finger enables scientists to navigate and analyze complex 3D images 2
... 19, 2012 /PRNewswire-iReach/ -- Global Information ... of forthcoming conferences and networking events in the ... events provide a platform for researchers and decision ... latest findings and learn about significant developments in ...
... have discovered the unexpected way in which a key cell ... said, offers insight into the processes that take place within ... from spinal cord injury to cancer. The research focused ... cell. Like other cells in the immune system, its job ...
... Va.The Office of Naval Research,s (ONR) biennial 2012 Naval ... Oct. 22-24, officials announced Jan. 19. "The chief ... Navy and Marine Corps, vision for 2025," said Rear ... is to bring the right people together to deliver ...
Cached Biology News:2012 Biotechnology and Pharmaceuticals: Forthcoming Conferences and Exhibitions 22012 Biotechnology and Pharmaceuticals: Forthcoming Conferences and Exhibitions 32012 Biotechnology and Pharmaceuticals: Forthcoming Conferences and Exhibitions 4UCSF team uncovers how immune cells move against invaders 2ONR sets date for 2012 Naval S&T Partnership Conference 2
(Date:7/10/2014)... July 10, 2014   Ceres, Inc . (Nasdaq: ... company, announced today financial results for the three months ... its business. Ceres reported that the company ... performance this growing season in Brazil, which concluded in ... company,s sorghum evaluation areas for part of the growing ...
(Date:7/10/2014)... of Adelaide research may help in the fight against ... detect tiny quantities of explosives with the use of ... journal Sensors and Actuators B: Chemical , the ... detect explosives in concentrations as low as 6.3 ppm ... only a few minutes. , "Traditionally explosives detection has ...
(Date:7/10/2014)... A new study published today in the journal ... has found that time of day and sleep deprivation ... could be crucial when looking at the best time ... and heart disease, and for administering medicines effectively. , ... of Cancer Research, London, investigated the links between sleep ...
(Date:7/10/2014)... the fractional quantum Hall effect in bilayer graphene and ... tuned by an electric field. , The fractional ... to thin sheets are exposed to large magnetic fields, ... of individual electrons behave as a single system. However, ... established, many details of this collective behavior remain not ...
Breaking Biology Technology:Ceres Announces Fiscal Third Quarter 2014 Financial Results 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 3Ceres Announces Fiscal Third Quarter 2014 Financial Results 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 5Ceres Announces Fiscal Third Quarter 2014 Financial Results 6Ceres Announces Fiscal Third Quarter 2014 Financial Results 7Ceres Announces Fiscal Third Quarter 2014 Financial Results 8Ceres Announces Fiscal Third Quarter 2014 Financial Results 9Detecting trace amounts of explosives with light 2Time of day crucial to accurately test for diseases, new research finds 2Columbia researchers observe tunable quantum behavior in bilayer graphene 2Columbia researchers observe tunable quantum behavior in bilayer graphene 3
... there's always one person in a crowd who is proud ... me. I'm compulsive about reading the job classifieds. , ,Don't ... the difference between the ubiquitous "excellent communication skills" and the ... quick scan every day, even if it happens to be ...
... a maker of automotive and ... bought Pro-Tel Inc. for an ... a contracting company founded in ... 70 employees. Its repair and ...
... Gas & Electric has released its 2005 Greater ... and updated listings covering 394 organizations. , ,The directory, ... offers an overview of the high-tech firms, professional organizations, ... in Dane County, as well as an array of ...
Cached Biology Technology:Is IT leadership a position or an attitude? 2Is IT leadership a position or an attitude? 32005 Madison-area tech directory includes more companies, resources 22005 Madison-area tech directory includes more companies, resources 3
... and G. Butcher (1998). • The major ... research in the immunology area. There is ... proteins and in their function as antigen-presenting ... with the prospect of tackling biochemical and ...
VACUGENE PUMP 110V, 1 EA. Category: Nucleid Acid Detection Systems....
Rat whole blood (Sprague-Dawley, averaging 7-8 weeks of age, either sex) is collected at the time of slaughter and refrigerated within 6 hours, and processed and frozen within 24 hours. The serum is ...
... mutS and ES1301 mutS are mismatch repair ... these strains prevents repair of the newly ... mutation efficiencies and making them helpful in ... Sites II Mutagenesis Systems. Both ES1301 and ...
Biology Products: