Navigation Links
Scientists use worms to unearth cancer drug targets
Date:8/9/2012

BETHESDA, MD August 9, 2012 -- Through novel experiments involving small nematode worms, scientists from Wyoming have discovered several genes that may be potential targets for drug development in the ongoing war against cancer. Specifically, researchers hypothesize that inhibiting these genes could reverse certain key traits associated with cancer cells. This discovery is published in the August 2012 issue of the Genetics Society of America's journal GENETICS (www.genetics.org).

"Cancer is a leading cause of death worldwide," said David S. Fay, Ph.D., a researcher involved in the work from the Molecular Biology Department at the University of Wyoming in Laramie. "We hope that by carrying out basic genetic research on one of the most widely implicated human cancer genes, that we can contribute to the arsenal of diverse therapeutic approaches used to treat and cure many types of cancer."

To make this discovery, Dr. Fay and his colleagues used a strain of nematode worms that carried a mutation in a gene similar to one that is inactivated in many human cancers. This gene, called "LIN-35" in worms and "pRb" in humans, is thought to control at least several aspects of tumor progression including cancer cell growth and survival. The researchers systematically inactivated other individual genes in the genome of the mutant LIN-35 worms. As they deactivated various genes, scientists identified those that led to a reversal of defects caused by the loss of LIN-35, suggesting that they could be used as targets for anti-cancer therapies.

"This research is important because it offers possible new ways to shut down the genetic machinery that contributes to cancer growth and progression," said Mark Johnston, Ph.D., Editor-in-Chief of the journal GENETICS. "The causes of cancer are complex and varied, so we must approach this disease from many angles. Using simple 'model organ
'/>"/>

Contact: Phyllis Edelman
pedelman@genetics-gsa.org
301-634-7302
Genetics Society of America
Source:Eurekalert

Page: 1 2

Related biology news :

1. Composite nanofibers developed by Penn scientists next chapter in orthopaedic biomaterials
2. Scientists define new limits of microbial life in undersea volcanoes
3. Farmers team with scientists to make the perfect rat trap
4. Scientists discover molecular link between circadian clock disturbances and inflammatory diseases
5. UTMB scientists awarded NIH grant for lab-grown lung tissue project
6. WHOI scientists/engineers partner with companies to market revolutionary new instruments
7. Stanford-Penn State scientists use microbes to make clean methane
8. Citizen scientists needed for SF States ZomBee Watch
9. Scientists confirm existence of vitamin deserts in the ocean
10. MBL scientists to explore hidden realm of microbes, viruses beneath the ocean floor
11. Scientists connect seawater chemistry with climate change and evolution
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... (SMU) The U.S. Department of Defense recently ... a $2.6 million grant to support its goal ... fields. STEMPREP recruits bright, science-minded minority middle school ... STEMPREP project, then provides high school students with ... based at SMU,s Annette Caldwell Simmons School of ...
(Date:7/23/2014)... Ore. -- A comprehensive 15-year analysis of the movements ... the United States found that their favored feeding areas ... threat of injury and mortality. , The researchers note ... San Francisco to slightly different areas at least, ... abundant could significantly decrease the probability of ships ...
(Date:7/23/2014)... 23, 2014 Migratory songbirds are disappearing, and though ... change, loss of habitat, acid rain and light pollution, ... where do these birds go once they leave their ... along the way? , To answer this question, a ... the first ever migratory connectivity map produced for a ...
Breaking Biology News(10 mins):Department of Defense awards $2.6 million grant to SMU STEM program for minority students 215-year analysis of blue whale range off California finds conflict with shipping lanes 215-year analysis of blue whale range off California finds conflict with shipping lanes 315-year analysis of blue whale range off California finds conflict with shipping lanes 4York University researchers use bird 'backpacks' to put wood thrushes migration on the map 2
... /PRNewswire-iReach/ -- Jade Holding Group, LLC dba Strax Rejuvenation, one ... centers, has just released a new radio ad that has ... is getting. In addition to mentioning how Strax can perform ... also stressed that regardless of what type of anesthesia is ...
... revealed that the stunning iridescent wings of the tropical ... technologies. Scientific lessons learnt from these butterflies have already ... Now research by the University of Exeter, in ... at Albany and Air Force Research Laboratory, and funded ...
... are captured in countless tourist photos. But enormous waves breaking ... a crucial role in long-term climate cycles. A University ... wave breaking in a key bottleneck for circulation in the ... in the journal Geophysical Research Letters . The ...
Cached Biology News:Strax Rejuvenation Releases a New Radio Ad that is Getting a Lot of Attention from Listeners 2Butterfly wings inspire new technologies: from fabrics and cosmetics to sensors 2Breaking deep-sea waves reveal mechanism for global ocean mixing 2Breaking deep-sea waves reveal mechanism for global ocean mixing 3
(Date:7/23/2014)... , July 23, 2014  GrowBLOX Sciences, Inc. (OTCQB: ... that it is filing for two medical marijuana dispensary locations ... are in addition to the Clark County, Nevada ... special use permit, as previously announced.  GrowBLOX Sciences, ... be submitting two new applications for dispensaries in the ...
(Date:7/23/2014)... MD (PRWEB) July 23, 2014 a2z ... and ChirpE Mobile App, AACC Pathfinder, in its ... offerings. AACC’s annual meeting is planned for July 29-31, ... the place to be to connect with global leaders ... lab management, and other areas of breaking science in ...
(Date:7/22/2014)... Even within a phylum so full of mean little ... arthropods for its cruelty -- at least to crickets. Native ... is a most predatory sort of parasite. It swoops onto ... of larvae, and leaves its wicked brood to invade, kill ... of this would be possible without the fly,s ability to ...
(Date:7/22/2014)... 22, 2014 Nuclear reactors are used ... by controlled fission chain reaction in nuclear reactors is ... used to drive a power- generating turbine. Currently nuclear ... world’s total electricity production. Nuclear reactor market is expected ... planned and proposed nuclear reactor projects. , Early buyers ...
Breaking Biology Technology:GrowBLOX Sciences, Inc. Files for Two Additional Medical Marijuana Dispensaries in Las Vegas 2GrowBLOX Sciences, Inc. Files for Two Additional Medical Marijuana Dispensaries in Las Vegas 3AACC Enhances Attendee Experience at Its 2014 Annual Meeting & Clinical Lab Expo with a2z-Powered ChirpE Photo Booth and Mobile App 2AACC Enhances Attendee Experience at Its 2014 Annual Meeting & Clinical Lab Expo with a2z-Powered ChirpE Photo Booth and Mobile App 3Fly-inspired sound detector 2Fly-inspired sound detector 3Fly-inspired sound detector 4Nuclear Energy Market: Global Industry Analysis, Size, Share, Analysis, Growth and Forecast 2013 - 2019 2Nuclear Energy Market: Global Industry Analysis, Size, Share, Analysis, Growth and Forecast 2013 - 2019 3
... The ALS Therapy Development Institute (ALS TDI) ... Silicon Valley entrepreneur, to its board of directors. ALS ... mission to discover and develop treatments that effectively slow ... (Logo: http://photos.prnewswire.com/prnh/20110204/DC42625LOGO ) "My ...
... of splitting layered materials to give atom thin "nanosheets" ... of novel two-dimensional nanomaterials with chemical and electronic properties ... energy storage technologies. The collaborative* international research led ... Nanodevices (CRANN), Trinity College Dublin, Ireland, and the University ...
... Van Beek, president and CEO of Van Beek Natural ... dogs and cats, available exclusively through veterinarians. ... containing both probiotics and prebiotics that work together to ... or cat,s GI tract.  Van Beek Natural Science,s formulations ...
Cached Biology Technology:ALS Therapy Development Institute Appoints Anil Godhwani to Board of Directors 2New nanomaterials unlock new electronic and energy technologies 2Van Beek Natural Science Announces New Synacore Digestive Support Product 2
... is designed for multiple user laboratories for ... TLC applications. The MultiDoc-It is available without ... provides a darkroom environment and protects the ... image capture and enhancement , The ...
PC based system for superior chemifluorescent, chemiluminescent, fluorescent and colorimetric, microarray and microscope imaging and analysis....
Pendrin (H-195)...
Request Info...
Biology Products: