Navigation Links
Scientists use worms to unearth cancer drug targets
Date:8/9/2012

BETHESDA, MD August 9, 2012 -- Through novel experiments involving small nematode worms, scientists from Wyoming have discovered several genes that may be potential targets for drug development in the ongoing war against cancer. Specifically, researchers hypothesize that inhibiting these genes could reverse certain key traits associated with cancer cells. This discovery is published in the August 2012 issue of the Genetics Society of America's journal GENETICS (www.genetics.org).

"Cancer is a leading cause of death worldwide," said David S. Fay, Ph.D., a researcher involved in the work from the Molecular Biology Department at the University of Wyoming in Laramie. "We hope that by carrying out basic genetic research on one of the most widely implicated human cancer genes, that we can contribute to the arsenal of diverse therapeutic approaches used to treat and cure many types of cancer."

To make this discovery, Dr. Fay and his colleagues used a strain of nematode worms that carried a mutation in a gene similar to one that is inactivated in many human cancers. This gene, called "LIN-35" in worms and "pRb" in humans, is thought to control at least several aspects of tumor progression including cancer cell growth and survival. The researchers systematically inactivated other individual genes in the genome of the mutant LIN-35 worms. As they deactivated various genes, scientists identified those that led to a reversal of defects caused by the loss of LIN-35, suggesting that they could be used as targets for anti-cancer therapies.

"This research is important because it offers possible new ways to shut down the genetic machinery that contributes to cancer growth and progression," said Mark Johnston, Ph.D., Editor-in-Chief of the journal GENETICS. "The causes of cancer are complex and varied, so we must approach this disease from many angles. Using simple 'model organ
'/>"/>

Contact: Phyllis Edelman
pedelman@genetics-gsa.org
301-634-7302
Genetics Society of America
Source:Eurekalert

Page: 1 2

Related biology news :

1. Composite nanofibers developed by Penn scientists next chapter in orthopaedic biomaterials
2. Scientists define new limits of microbial life in undersea volcanoes
3. Farmers team with scientists to make the perfect rat trap
4. Scientists discover molecular link between circadian clock disturbances and inflammatory diseases
5. UTMB scientists awarded NIH grant for lab-grown lung tissue project
6. WHOI scientists/engineers partner with companies to market revolutionary new instruments
7. Stanford-Penn State scientists use microbes to make clean methane
8. Citizen scientists needed for SF States ZomBee Watch
9. Scientists confirm existence of vitamin deserts in the ocean
10. MBL scientists to explore hidden realm of microbes, viruses beneath the ocean floor
11. Scientists connect seawater chemistry with climate change and evolution
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... awarded the Oklahoma Medical Research Foundation a five-year, $14.5 ... the bacteria,s effects on humans. , For 10 ... have studied the human immune response to anthrax bacteria ... The original funding came soon after anthrax-laced letters killed ... terrorist attacks of Sept. 11, 2001. , The ...
(Date:8/20/2014)... the past few years, Virginia Tech,s Wu Feng has ... grant from the "Computing in the Cloud" program, and ... $6 million award from the Air Force on "big ... NSF and the National Institutes of Health on "big ... together the "parallel computing" aspects from each grant, he ...
(Date:8/20/2014)... for electronically manipulating the flight muscles of moths and ... those muscles. The work opens the door to the ... emergency response. , "In the big picture, we want ... moths for use in applications such as search and ... of electrical and computer engineering at NC State and ...
Breaking Biology News(10 mins):$14.5 million grant awarded to continue anthrax studies 2The internet was delivered to the masses; parallel computing is not far behind 2The internet was delivered to the masses; parallel computing is not far behind 3The internet was delivered to the masses; parallel computing is not far behind 4Research paves way for development of cyborg moth 'biobots' 2
... for creating chemical reactions between single molecules, scientists ... (NIST) have employed microfluidicsthe manipulation of fluids at ... molecules of interest. By combining this new microfluidic ... multiple droplets and cause their molecular contents to ...
... Researchers at the National Institute of Standards and ... other government agencies, have produced a new reference ... used as a hardener in high-performance alloys and ... fatal illness. The new reference material is expected ...
... that dust from a nearby construction zone will harm your ... confirm your suspicions or better yet, set your mind at ... Sandra Chudnovsky, of TAU,s Department of Geography have developed a ... ― to help families and authorities monitor the quality ...
Cached Biology News:New nanochemistry technique encases single molecules in microdroplets 2New beryllium reference material for occupational safety monitoring 2Tel Aviv University invention busts dust 2Tel Aviv University invention busts dust 3
(Date:8/21/2014)... VIEW, Calif. , Aug. 21, 2014 /PRNewswire/ ... properties and behaviors based on external stimuli such ... poised to have a disruptive effect in multiple ... revolutionize the business landscape by printing objects ranging ... aerospace and automotive sectors. Logo - ...
(Date:8/21/2014)... 21, 2014 Gallus BioPharmaceuticals ... development and manufacturing organization (CMO) announced today that ... an oncology company focused on the development of ... manufacture the anti-prostate specific membrane antigen (PSMA) monoclonal ... Under the agreement the antibody will be ...
(Date:8/20/2014)... Aug. 20, 2014 Clintrax Global, Inc., ... in Raleigh, NC , recently ... as Vice President of Administration. ... all corporate processes, including their alignment with company ... Brad worked as an HR executive, specializing in ...
(Date:8/20/2014)... time, chemists have succeeded in measuring vibrational motion of ... study reveals how vibration of a single molecule differs ... The study was performed at the University of California, ... of Jyvskyl works as a visiting fellow under professor ... The second team was lead by Professor Eric O. ...
Breaking Biology Technology:Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 2Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 3Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 4Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 2Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 3Clintrax Global, Inc. Announces Addition to Executive Team 2Seeing a molecule breathe 2
... Kingdom and GAITHERSBURG, Md., Oct. 29 /PRNewswire/,-- ... name to MedImmune to,reflect AstraZeneca,s vision for ... will unite the resources and expertise from ... activities within the AstraZeneca,Group, under the "MedImmune" ...
... the Innovator in,Ultrasound for more than 50 years, announced ... for advanced cardiac and,vascular imaging, the ProSound Alpha 10 ... American Heart Association, at the Orange County,Convention Center in ... 7 and the Alpha 10 incorporate all of the ...
... WaferGen Biosystems,Inc. (OTC Bulletin Board: WGBS), a ... and stem cell research systems,today announced that Mr. ... a corporate presentation at the Acumen BioFin Rodman,& ... be held,November 5 - 7, 2007, at the ...
Cached Biology Technology:AstraZeneca Bolsters Its Worldwide Biologics Division Through Integration of Cambridge Antibody Technology Into MedImmune 2ALOKA to Introduce New 'ProSound' Diagnostic Ultrasound Systems at the Scientific Session 2007 of American Heart Association, 4th to 7th of November 2007 in Orlando, Florida 2ALOKA to Introduce New 'ProSound' Diagnostic Ultrasound Systems at the Scientific Session 2007 of American Heart Association, 4th to 7th of November 2007 in Orlando, Florida 3WaferGen to Present at the Acumen BioFin Rodman & Renshaw 9th Annual Healthcare Conference 2
Anti-GOSR2 Monoclonal AntibodyOther Sub-Family: not assigned-Other Applications: Immunocytochemistry, Immunoprecipitation, Western Blot...
... Synthetic peptide corresponding ... Antigen Family: ... Antigen Subfamily: not ... Recommended Storage: Long ...
Anti-DNA Polymerase a, Human Description: 50 l Research Focus: cancer & cell proliferation Storage: 4C Shipping Temperature: 4C...
... PROTEAN II xi 2-D system runs both gel dimensions ... tube gels can be separated in a single run ... cooling core in much the same manner as the ... the second-dimension slab gels may be cast in the ...
Biology Products: