Navigation Links
Scientists use super microscope to pinpoint body’s immunity 'switch'
Date:6/5/2011

Using the only microscope of its kind in Australia, medical scientists have been able for the first time to see the inner workings of T-cells, the front-line troops that alert our immune system to go on the defensive against germs and other invaders in our bloodstream.

The discovery overturns prevailing understanding, identifying the exact molecular 'switch' that spurs T-cells into action a breakthrough that could lead to treatments for a range of conditions from auto-immune diseases to cancer.

The findings, by researchers at the University of New South Wales (UNSW), are reported this week in the high-impact journal Nature Immunology.

Studying a cell protein important in early immune response, the researchers led by Associate Professor Katharina Gaus from UNSW's Centre for Vascular Research at the Lowy Cancer Research Centre, used Australia's only microscope capable of super-resolution fluorescence microscopy to image the protein molecule-by-molecule to reveal the immunity 'switch'.

The technology is a major breakthrough for science, Dr Gaus said. Currently there are only half a dozen of the 'super' microscopes in use around the world.

"Previously you could see T-cells under a microscope but you couldn't see what their individual molecules were doing," Dr Gaus said.

Using the new microscope the scientists were able to image molecules as small as 10 nanometres. Dr Gaus said that what the team found overturns the existing understanding of T-cell activation.

"Previously it was thought that T-cell signalling was initiated at the cell surface in molecular clusters that formed around the activated receptor.

"In fact, what happens is that small membrane-enclosed sacks called vesicles inside the cell travel to the receptor, pick up the signal and then leave again," she said.

Dr Gaus said the discovery explained how the immune response could occur so quickly.

"There is thi
'/>"/>

Contact: Dr. Katharina Gaus
k.gaus@unsw.edu.au
61-293-851-377
University of New South Wales
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scripps Research scientists find way to block stress-related cell death
2. Scripps Research scientists find key mechanism in transition to alcohol dependence
3. Harvard scientists see the early cellular cause of dry eye disease for the first time
4. Scientists crack the spiders web code
5. Scientists discover fossil of giant ancient sea predator
6. Scientists discover the largest assembly of whale sharks ever recorded
7. Syracuse University scientists discover new hitch to link nerve cell motors to their cargo
8. Scientists list top 10 new species
9. Scientists find new drug target in breast cancer
10. Wildlife in trouble from oil palm plantations, according to scientists
11. UCSB scientists make strides in vision research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/11/2014)... 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced the addition ... report to their offering. ... the adoption of multimodal biometric systems. Multimodal biometric ... individual for verification and identification purposes. This helps ...
(Date:12/10/2014)... , Dec. 8, 2014 You,ve been here ... account but can,t remember your password, site key or the ... was your first grade teacher? Today, ... the app that will finally put an end to ... 1U TM . 1U leverages a user,s smartphone ...
(Date:12/10/2014)... 2014 CIE San Diego has launched an ... connective tissue that enhances care coordination among social service ... client-level information; earned a second $1 million grant from ... seniors aging in community and; will be recognized as ... th 4-6p. CIE San Diego today ...
Breaking Biology News(10 mins):Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4
... (Pink Sheets: ESMT); with its parent company IVI Smart ... that it has,delivered the Company,s newest Super Smart Card(TM), ... Both companies celebrated the delivery of the "I AM"(TM) ... Center in Seoul, Korea,presided over by Mr. Teawon Park, ...
... Center at Washington University School of Medicine increased its ... Genome Sequencer FLX Systems from Roche Diagnostics. With ... Genome Sequencing Center will be able to support a ... ranging from the sequencing of new complex genomes to ...
... that harvests far-red light by making a rare form ... according to a team of researchers who recently sequenced ... State University and Washington University, St. Louis, report in ... of the National Academy of Sciences, that they have ...
Cached Biology News:e-Smart(R) Technologies Delivers Its New Super Smart Card(TM) in South Korea. 2Washington University increases fleet of Roche Genome Sequencer FLX Systems 2Washington University increases fleet of Roche Genome Sequencer FLX Systems 3Researchers decode genetics of rare photosynthetic bacterium 2Researchers decode genetics of rare photosynthetic bacterium 3
(Date:12/24/2014)... 2014 Sigma-Aldrich Corporation (NASDAQ: ... under the Hart-Scott-Rodino Antitrust Improvements Act (HSR Act) ... 22, 2014, thereby completing the U.S. HSR Act ... of the Company by Merck KGaA, Darmstadt, Germany.  ... condition to closing the transaction, which remains subject ...
(Date:12/22/2014)... , Dec. 22, 2014 /PRNewswire/ - RepliCel Life ... regenerative medicine company focused on the development of autologous ... out of the University of Calgary in conjunction with ... Carolina, which further validates the company,s ongoing clinical research ... effects of pattern baldness. The paper entitled ...
(Date:12/22/2014)... ITRA Global, one of the largest organizations ... estate, has further expanded its global reach with the ... Western Australia, reports Mylinda Vick, CCIM, Chairman of the ... / ACORPP (Australian Corporate Property and Projects) , is ... services to a wide range of clients in the ...
(Date:12/19/2014)... Dec. 19, 2014 Naurex Inc., a biopharmaceutical ... for diseases of the central nervous system, today announced ... executive officer, will present at the 33 rd ... take place at 3:00 p.m. PST on Tuesday, January ... San Francisco, Calif. ...
Breaking Biology Technology:Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 2Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 3Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 2Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 3Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 4Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 5ITRA Global Continues International Expansion in Perth and Brisbane, Australia 2Naurex to Present at 33rd Annual J.P. Morgan Healthcare Conference 2
... , D.J. Lowrie Jr. ,Department of Cell Biology, ... Medicine, Cincinnati, OH 45267 , , Transfection of ... of,liposome-based reagents. Here we compare the transfection efficiency ... both LipoTAXI ,transfection reagent ...
... Taq DNA polymerase , makes hot start simple and efficient , ... , , , Jonathan Eads ... Stratagene , , , ... Taq , DNA polymerase , ...
... and effort needed for,transformationswithout compromise! , Anna Waesche ... Alan Greener ,Stratagene , Stratagene introduces competent cells from ... easy-to-use, single-reaction format that,yield the supercompetent efficiency of 1 ... the competent efficiency of 1 x 10 8 ...
Cached Biology Technology:Transfection of Green Fluorescent Protein into Human Adrenalcarcinoma Cells 2Transfection of Green Fluorescent Protein into Human Adrenalcarcinoma Cells 3Transfection of Green Fluorescent Protein into Human Adrenalcarcinoma Cells 4Greater Amplification Specificity with New Hot Start PCR Enzyme 2Greater Amplification Specificity with New Hot Start PCR Enzyme 3Greater Amplification Specificity with New Hot Start PCR Enzyme 4Greater Amplification Specificity with New Hot Start PCR Enzyme 5Greater Amplification Specificity with New Hot Start PCR Enzyme 6Greater Amplification Specificity with New Hot Start PCR Enzyme 7XL10-Gold Cells Supplied in New Single-Reaction Format 2XL10-Gold Cells Supplied in New Single-Reaction Format 3XL10-Gold Cells Supplied in New Single-Reaction Format 4
Anti-Src-Like Adaptor Protein-2 AVOID FREEZE/THAW CYCLES. Recognizes the ~25 and ~28 kDa forms SLAP-2....
... media for spontaneous ligand immobilization can be coupled ... antigen, or receptor to create an affinity matrix ... couple ligands via primary amines. Affi-Gel 10 gel ... 6.5 to 11; Affi-Gel 15 gel couples acidic ...
pH-dependent fluorescence; Maximum intensity observed in basic solutions....
Anti-Chicken IgY, (IgG) F(ab')2 Fragment Specific....
Biology Products: