Navigation Links
Scientists use nanosensors for first time to measure cancer biomarkers in blood
Date:12/13/2009

New Haven, Conn.A team led by Yale University researchers has used nanosensors to measure cancer biomarkers in whole blood for the first time. Their findings, which appear December 13 in the advanced online publication of Nature Nanotechnology, could dramatically simplify the way physicians test for biomarkers of cancer and other diseases.

The teamled by Mark Reed, Yale's Harold Hodgkinson Professor of Engineering & Applied Science, and Tarek Fahmy, an associate professor of biomedical and chemical engineeringused nanowire sensors to detect and measure concentrations of two specific biomarkers: one for prostate cancer and the other for breast cancer.

"Nanosensors have been around for the past decade, but they only worked in controlled, laboratory settings," Reed said. "This is the first time we've been able to use them with whole blood, which is a complicated solution containing proteins and ions and other things that affect detection."

To overcome the challenge of whole blood detection, the researchers developed a novel device that acts as a filter, catching the biomarkersin this case, antigens specific to prostate and breast canceron a chip while washing away the rest of the blood. Creating a buildup of the antigens on the chip allows for detection down to extremely small concentrations, on the order of picograms per milliliter, with 10 percent accuracy. This is the equivalent of being able to detect the concentration of a single grain of salt dissolved in a large swimming pool.

Until now, detection methods have only been able to determine whether or not a certain biomarker is present in the blood at sufficiently high concentrations for the detection equipment to give reliable estimates of its presence. "This new method is much more precise in reading out concentrations, and is much less dependent on the individual operator's interpretation," Fahmy said.

In addition to relying on somewhat subjective i
'/>"/>

Contact: Suzanne Taylor Muzzin
suzanne.taylormuzzin@yale.edu
203-432-8555
Yale University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Scripps Research scientists crack mystery of proteins dual function
2. Scientists identify natural anti-cancer defenses
3. Princeton scientists find way to catalog all that goes wrong in a cancer cell
4. The pitch of blue whale songs is declining around the world, scientists discover
5. Stand Up to Cancer funds high-risk/high-reward cancer research by 13 young scientists
6. Scientists discover gene module underlying atherosclerosis development
7. Scientists think killer petunias should join the ranks of carnivorous plants
8. Scientists gain new understanding of disease-causing bacteria
9. How can scientists measure evolutionary responses to climate change?
10. Seeing family for the holidays? Scientists discover how the stress might kill you
11. The pill for him: Scientists find a hormonal on-and-off switch for male fertility
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists use nanosensors for first time to measure cancer biomarkers in blood
(Date:7/8/2015)... 2015 Summary Pancreatic cancer is the ... fatal, with a mortality rate of 10.9 deaths per ... cancer patients has highlighted a significant need for new ... met by the current market. A highly active ... varying molecule types and mechanisms of action, which provides ...
(Date:7/7/2015)... , July 7, 2015  Based on ... Frost & Sullivan recognizes Credence ID, LLC with ... Entrepreneurial Company of the Year Award. Credence ID ... aid in its mission of offering enrollment and ... globally. As Credence ID was formed by experts ...
(Date:6/30/2015)... 2015 To bolster its efforts and commitment to ... today the addition of two new team members. ... and David Raviv will act as head of ... commitment to providing the most secure solutions for the enterprise ... Layer 7 Technologies, a provider of security and management products, ...
Breaking Biology News(10 mins):Frontier Pharma: Pancreatic Cancer - Identifying and Commercializing First-in-Class Innovation 2Frontier Pharma: Pancreatic Cancer - Identifying and Commercializing First-in-Class Innovation 3Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 2Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 3Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 4Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 5HYPR Corp. Expands Biometric Authentication Team with Enterprise All Stars 2HYPR Corp. Expands Biometric Authentication Team with Enterprise All Stars 3
... Studies show 97 percent of American adults get less ... the minimum recommended amount based on federal guidelines. New ... traits may predispose people to being more or less ... professor in the MU College of Veterinary Medicine, along ...
... Barcelona have discovered new clues about past rapid climate ... journal Nature Geoscience , concludes that oceanographic reorganisations ... airborne dust in the Southern Ocean and this connection ... atmospheric carbon dioxide levels, an important component in the ...
... A team of researchers, led by Marc Freeman, PhD, an ... associate professor of neurobiology at the University of Massachusetts Medical ... Drosophila melanogaster that, when mutant, blocks the self-destruction of ... diseases, such as amyotrophic lateral sclerosis (ALS). A ...
Cached Biology News:Couch potatoes may be genetically predisposed to being lazy, MU study finds 2Rapid climate change and the role of the Southern Ocean 2A fly mutation suggests a new route for tackling ALS 2A fly mutation suggests a new route for tackling ALS 3
(Date:7/30/2015)... (PRWEB) , ... July 30, 2015 , ... As part of its 2015 growth plan ... and technical service business units, Whitehouse Laboratories is pleased to announce that ... adjacent to the Container Center of Excellence and will be strictly dedicated to basic USP ...
(Date:7/29/2015)... , July 30, 2015 ... results for the second quarter of 2015. CEO ... results and its performance in different businesses. ... http://www.eurobusinessmedia.com/ceo-direct/sanofi/sanofi-h1-2015-results-interview-with-ceo-olivier-brandicourt?utm_source=ceo-direct&utm_medium=wire Topics covered ... results - Performance drivers ...
(Date:7/29/2015)... 2015 According to a new market ... & Forecasts (2015-2020), , published by Mordor Intelligence, the Global ... the end of 2020, with North America ... 40% of the global market size. The Global market for ... 13.7% during the period of (2015-2020).      (Logo: ...
(Date:7/29/2015)... (Q2 2015: +14% CER / 20% of sales) led the regional performance ... , as well as solid contributions from Korea, India ... Middle East / Africa (Q2 ... , Turkey and the United Kingdom ... 11%, excluding U.S. HPV sales, on demand across all customer classes. The top ...
Breaking Biology Technology:Whitehouse Labs Formally Announces Plans to Open a Microbiological Laboratory 2Asia Pacific to Dominate the Global Stem Cell Market - Vericel Corporation, Ocata Therpeutics, Athersys Inc., Cryo-Cell International, Geron Corporation, StemCells, Inc. Among the Major Players 2Asia Pacific to Dominate the Global Stem Cell Market - Vericel Corporation, Ocata Therpeutics, Athersys Inc., Cryo-Cell International, Geron Corporation, StemCells, Inc. Among the Major Players 3QIAGEN Reports Results for Second Quarter and First Half of 2015 2QIAGEN Reports Results for Second Quarter and First Half of 2015 3QIAGEN Reports Results for Second Quarter and First Half of 2015 4QIAGEN Reports Results for Second Quarter and First Half of 2015 5QIAGEN Reports Results for Second Quarter and First Half of 2015 6QIAGEN Reports Results for Second Quarter and First Half of 2015 7QIAGEN Reports Results for Second Quarter and First Half of 2015 8QIAGEN Reports Results for Second Quarter and First Half of 2015 9QIAGEN Reports Results for Second Quarter and First Half of 2015 10
... Nov. 21, 2011 Double Eagle Holdings, Ltd. (OTCQB: DROP), ... announced last week a partnership with golf superstar Tiger Woods ... his bag. Woods and CEO of FUSE Science Adam Adler ... partnership on CNBC today Monday, November 21, at 12:30 p.m. ...
... The report " Leukemia Therapeutics Market (Acute/Chronic ... Global Market Forecast (2010 - 2020) " ... opportunities in North America, & Europe. ... Leukemia Therapeutics Market (Acute/Chronic Lymphocytic Leukemia & Acute/Chronic Myeloid ...
... 2011 - A research group from RIKEN, the University ... today announced that research results obtained using the "K ... at SC11, the International Conference for High Performance Computing, ... November 17 (US Pacific Standard Time). The award-winning ...
Cached Biology Technology:Tiger Woods Gives Exclusive First Interview Since POWERED by FUSE Announcement! 2MarketsandMarkets: Leukemia Therapeutics Market Worth $11.3 Billion by 2020 2MarketsandMarkets: Leukemia Therapeutics Market Worth $11.3 Billion by 2020 3'K computer' research results awarded ACM Gordon Bell Prize 2
Secure-Seal™ hybridization chamber gasket, eight chambers, 9 mm diameter, 0.8 mm deep *set of 20*...
Recombinant Rat CINC-2 beta, CF...
RAT ANTI MOUSE F4/80 ANTIGEN:BIOTIN Immunogen: Thioglycollate stimulated peritoneal macrophages from C57/BL mice...
SHEEP ANTI FLECAINIDE...
Biology Products: