Navigation Links
Scientists use computer algorithms to develop seasonal flu vaccines
Date:7/9/2010

CORAL GABLES, FL (July 9, 2010) Defeating the flu is challenging because the virus responsible for the disease undergoes frequent changes of its genetic code, making it difficult for scientists to manufacture effective vaccines for the seasonal flu in a timely manner. Now, a University of Miami (UM) computer scientist, Dimitris Papamichail, and a team of researchers from Stony Brook University have developed a rapid and effective approach to produce vaccines for new strains of influenza viruses. The researchers hope to develop the new technology and provide an efficient method to confront the threat of seasonal epidemics.

The novel approach uses computer algorithms created by Papamichail and scientists from Stony Brook University to design viruses that serve as live vaccines, which are then synthesized to specification. The new method is called Synthetic Attenuated Virus Engineering (SAVE). The findings are available in a study titled "Live attenuated influenza virus vaccines by computer-aided rational design," now available as an advance online publication by Nature Biotechnology.

"We have been able to produce an entirely novel method to systematically design vaccines using computer algorithms," says Papamichail, assistant professor of Computer Science in the College of Arts and Sciences at UM and co-author of the study. "Our approach is not only useful for influenza; it is also applicable to a wide range of viruses."

One way to make an anti-viral vaccine is to weaken a virus to the point where it cannot cause sickness, and then use the weakened virus as a live vaccine. Although such weakened viruses often make very effective vaccines, they suffer from the possibility that the virus can sometimes mutate to regain virulence.

In this study, the researchers used a novel approach to weaken the influenza virus: they made a synthetic genome of the virus containing hundreds of changes to its genetic code. The computer algorithms indicate the best places in the genome to make the changes, such that the new synthetic genome encodes exactly the same proteins as the wild-type genome, but in lesser quantities.

This process allows a wide margin of safety, explains Papamichail. "The probability of all the changes reverting themselves to produce a virulent strain is extremely unlikely," he says.

Although the new sequence and the original sequence both direct the synthesis of exactly the same proteins, the new sequence gives a weakened version of the virus; for that reason the live vaccine is capable of eliciting an immune reaction against the wild-type virus, but is not strong enough to cause disease symptoms. This method used to weaken the influenza virus is a general one, and may allow the creation of safe, effective vaccines against many different types of viruses.

In the future, the researchers would like to explore the applicability of their techniques, with the ultimate goal of methodically and computationally design from scratch synthetic organisms with predetermined functions and controlled properties, with broad applications in medicine.


'/>"/>

Contact: Marie Guma-Diaz
m.gumadiaz@umiami.edu
305-284-1601
University of Miami
Source:Eurekalert

Related biology news :

1. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
2. Scientists identify novel inhibitor of human microRNA
3. Argonne scientists peer into heart of compound that may detect chemical, biological weapons
4. MU scientists go green with gold, distribute environmentally friendly nanoparticles
5. Scientists identify gene that may contribute to improved rice yield
6. Scientists discover why a mothers high-fat diet contributes to obesity in her children
7. MU scientists see how HIV matures into an infection
8. Earth scientists keep an eye on Texas
9. Thinking it through: Scientists call for policy to guide biofuels industry toward sustainability
10. Scientists identify a molecule that coordinates the movement of cells
11. Scientists Find new migratory patterns for Mediterranean and Western Atlantic bluefin tuna
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2016)... , March 31, 2016   ... ("LegacyXChange" or the "Company") LegacyXChange is excited ... of its soon to be launched online site for ... https://www.youtube.com/channel/UCyTLBzmZogV1y2D6bDkBX5g ) will also provide potential shareholders a ... DNA technology to an industry that is notorious for ...
(Date:3/29/2016)... RATON, Florida , March 29, 2016 ... or the "Company") LegacyXChange "LEGX" and SelectaDNA/CSI Protect are ... DNA in ink used in a variety of writing ... theft. Buyers of originally created collectibles from athletes on ... through forensic analysis of the DNA. ...
(Date:3/22/2016)... 22, 2016 According ... Market for Consumer Industry by Type (Image, Motion, ... (Communication & IT, Entertainment, Home Appliances, & ... to 2022", published by MarketsandMarkets, the market ... reach USD 26.76 Billion by 2022, at ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... the release of its second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” ... and retention in this eBook by providing practical tips, tools, and strategies for ...
(Date:6/23/2016)... June 23, 2016   Boston Biomedical , ... compounds designed to target cancer stemness pathways, announced ... granted Orphan Drug Designation from the U.S. Food ... gastric cancer, including gastroesophageal junction (GEJ) cancer. Napabucasin ... to inhibit cancer stemness pathways by targeting STAT3, ...
(Date:6/23/2016)... -- A person commits a crime, and the detective uses ... criminal down. An outbreak of foodborne illness makes ... uses DNA evidence to track down the bacteria that caused ... not. The FDA has increasingly used a complex, cutting-edge technology ... Put as simply as possible, whole genome sequencing is a ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... Plate® YM (Yeast and Mold) microbial test has received AOAC Research Institute approval ... of microbial tests introduced last year,” stated Bob Salter, Vice President of Regulatory ...
Breaking Biology Technology: