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Scientists unlock possible aging secret in genetically altered fruit fly
Date:1/22/2009

at mechanisms lead to the longer life of the fruit fly. (Indy flies' life span increased from an average life span of about 35 days to 70 days.

The researchers decided the best way to try to understand how the Indy mutation might extend life span would be to study the differences in molecular changes between the Indy flies and normal flies throughout their entire life. By comparing the expression level of all genes in the Indy flies to that of normal flies, they made an important finding. Some of the genes involved in generating the power necessary for normal cell life were expressed at lower levels in the Indy flies.

This led to a decrease in free radicals and the damage they normally cause in the cell, but it surprisingly did not decrease the overall amount of energy in the cell. These studies provide evidence for possible interventions that can alter metabolism in a way that reduces free-radical or oxidative damage and extends life span, without some of the negative consequences normally associated with a change in metabolism.


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Contact: Mark Hollmer
Mark_Hollmer@brown.edu
401-863-1862
Brown University
Source:Eurekalert

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