Navigation Links
Scientists unlock possible aging secret in genetically altered fruit fly
Date:1/22/2009

PROVIDENCE, R.I. [Brown University] Brown University researchers have identified a cellular mechanism that could someday help fight the aging process.

The finding by Stephen Helfand and Nicola Neretti and others adds another piece to the puzzle that Helfand, a professor of biology, molecular biology, cell biology and biochemistry, first discovered in 2000. Back then, he identified a mutation in the Indy ("I'm Not Dead Yet") gene that can extend the life span of fruit flies.

Subsequent studies of the Indy flies have led to the new finding that a mechanism in those genetically altered fruit flies appears to reduce significantly the production of free radicals, a cellular byproduct that can contribute to the aging process. This intervention takes place with few or no side effects on the quality of life for the fruit fly. The discovery could lead to the development of new anti-aging treatments.

"There are very few, if any, interventions that are known to dramatically extend healthy lifespan," Helfand said. "Understanding how the Indy mutation alters the metabolic state of the fruit fly would allow someone to come up with pharmacological interventions that could mimic it and give you the benefit of genetic manipulation without having to do genetics."

The findings are detailed in new research published Jan. 21 in the online Early Edition of the Proceedings of the National Academy of Sciences. Titled "Long-lived Indy reduced mitochondrial reactive oxygen species production and oxidative damage," the piece includes a number of collaborators. Helfand served as senior author and Neretti, assistant professor (research) in Brown's Institute for Brain and Neural Systems, served as lead author. Other researchers collaborated from the University of Chicago and the University of Connecticut Health Center.

With Helfand having established that the mutated Indy gene helped fruit flies live longer, he now wanted to explore wh
'/>"/>

Contact: Mark Hollmer
Mark_Hollmer@brown.edu
401-863-1862
Brown University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Jefferson scientists discover a key protein regulator of inflammation and cell death
2. MUHC and McGill scientists explain genetic disease first discovered in Quebec 24 years ago
3. Scientists uncover evolutionary keys to common birth disorders
4. Invasive plants challenge scientists in face of environmental change
5. Key to future medical breakthroughs is systems biology, say leading European scientists
6. Scripps scientists develop first examples of RNA that replicates itself indefinitely
7. Florida professor creates endowment for insect scientists
8. NYU scientists discover dangerous new method for bacterial toxin transfer
9. Scientists can now differentiate between healthy cells and cancer cells
10. Scientists make strides toward defining genetic signature of Alzheimers disease
11. Johns Hopkins scientists pull proteins tail to curtail cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/2/2015)... At its 2015 ACMG Annual Clinical Genetics ... the American College of Medical Genetics and Genomics (ACMG) ... Board.  Members of the ACMG Board of Directors serve ... advancing its policies and programs. ACMG is the national ... an eventful time in medical genetics and genomics.  We ...
(Date:4/2/2015)... , April 2, 2015 ... touch fingerprint sensor FPC1025 from the distributor World Peace ... commence during Q2 2015 although the major part of ... sensors will be used by smartphone manufacturers in ... MSEK is included in the communicated revenue guidance of ...
(Date:4/1/2015)... --  Medisafe ™, the leading global medication management platform ... and Android smartphones and tablets, announces today ... to allow patients to track and correlate their adherence ... will be able to visualize in real-time how taking ... as glucose levels and blood pressure. "Patients ...
Breaking Biology News(10 mins):American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 5American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 6American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 7American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 8Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 110 Million 2Medisafe Announces Launch of Biometric Integration, Enabling Patients to Stay Adherent to Their Meds and See Tangible Health Results 2
... The biggest ever single UK public investment in bioenergy ... main funding agency for the biosciences the Biotechnology ... 27M BBSRC Sustainable Bioenergy Centre has been launched to ... and emerging UK sustainable bioenergy sector and to ...
... Switzerland, Jan. 26 SVOX, the leading provider ... the Professional,Speech Processing Group of Siemens AG, according ... speech technology-related IP of Siemens AG developed,over 25 ... more than 60 patent families. The majority of ...
... Spring Harbor Laboratory (CSHL) announced today the discovery of ... time, they reported that their discovery suggests the presence ... in which these and possibly other small RNAs are ... project called ENCODE, also provided information concerning the biological ...
Cached Biology News:Biggest ever public investment in bioenergy to help provide clean, green and sustainable fuels 2SVOX Acquires Speech Processing Unit of Siemens AG, Expands Into Speech Recognition and Speech Dialog 2CSHL scientists find a new class of small RNAs and define its function 2CSHL scientists find a new class of small RNAs and define its function 3
(Date:5/5/2015)... , May 5, 2015  23andMe, Inc., the ... the Lupus Research Study in collaboration with ... with systemic lupus erythematosus, more commonly known as lupus, ... of lupus. The effort is also in collaboration with ... Awareness Month in May. Approximately 1.5 million ...
(Date:5/5/2015)... May 5, 2015 Psyche Systems Corporation and ... offers a first-of-its-kind platform that helps labs comply with ... results, transforms the way patients engage with these results, ... Health provides a HIPAA-compliant digital platform that gives ... and understand their lab results, and uniquely connects labs, ...
(Date:5/5/2015)... , May 5, 2015 Reprints Desk, Inc., ... providing on-demand access to scientific, technical and medical (STM) ... the Association of Southeastern Research Libraries (ASERL) . ... libraries located across 11 southeastern states. Founded in 1956, ... collaborative programs to address the continually changing needs of ...
(Date:5/5/2015)... Franz Inc ., the leading supplier ... its flagship product, AllegroGraph, has been named a Champion by ... report. AllegroGraph is a high performance Semantic Graph ... Graph databases are skyrocketing in popularity and have grown by ... DBMS ranking by DB-Engines. , “We are excited ...
Breaking Biology Technology:23andMe Launches the Lupus Research Study in Collaboration with Pfizer Inc. 223andMe Launches the Lupus Research Study in Collaboration with Pfizer Inc. 3Psyche Systems Corporation Forms Strategic Alliance with Luminate Health to Provide First-of-its-kind Patient Access Solution 2Psyche Systems Corporation Forms Strategic Alliance with Luminate Health to Provide First-of-its-kind Patient Access Solution 3Association of Southeastern Research Libraries Partners with Reprints Desk to Improve Access for Hard-to-Find Materials 2Association of Southeastern Research Libraries Partners with Reprints Desk to Improve Access for Hard-to-Find Materials 3Association of Southeastern Research Libraries Partners with Reprints Desk to Improve Access for Hard-to-Find Materials 4Bloor Research Positions AllegroGraph as a ‘Champion’ in Burgeoning Graph Database Market 2Bloor Research Positions AllegroGraph as a ‘Champion’ in Burgeoning Graph Database Market 3
... Brinks Hofer Gilson & Lione, one of the,largest intellectual ... new office in the Raleigh/Durham, North Carolina area and welcomes ... who will be,based in the Raleigh office. Mr. Baum and ... as partners. The office will officially,be open for business on ...
... N.J., July 9 Par,Pharmaceutical Companies, Inc. (NYSE: ... 12.5mg and 25mg meclizine HCl tablets immediately. At,this time, ... AB-rated,generic product., Par marketed meclizine prior to an ... 2008. Par has since qualified a new API source ...
... Inc. (Nasdaq: ALXA ) announced today that ... Global Supply Chain and,Sustainment Engineering. He will have ... global supply chain strategy to,support the commercialization of ... AZ-004 (Staccato(R) loxapine) is in,Phase 3 clinical testing ...
Cached Biology Technology:Brinks Hofer Gilson & Lione Expands to High-Tech Raleigh/Durham Area; Adds Accomplished Patent Attorneys to Its New Office 2Brinks Hofer Gilson & Lione Expands to High-Tech Raleigh/Durham Area; Adds Accomplished Patent Attorneys to Its New Office 3Par Pharmaceutical to Launch meclizine HCL Tablets 2Christopher Kurtz Joins Alexza Pharmaceuticals as Vice President, Global Supply Chain and Sustainment Engineering 2Christopher Kurtz Joins Alexza Pharmaceuticals as Vice President, Global Supply Chain and Sustainment Engineering 3
... PROTEAN II xi 2-D system runs both gel dimensions ... tube gels can be separated in a single run ... cooling core in much the same manner as the ... the second-dimension slab gels may be cast in the ...
... all the accessories necessary for casting gels ... analysis (SSCP) with the DCode universal mutation ... finger adaptor for use with an external ... cm plates, 2 sets of 0.75 mm ...
...
...
Biology Products: