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Scientists uncover the potential to control adult stem cells
Date:4/10/2008

ystem that relays and coordinates the signals from certain growth factors to the MSCs, which encourage their recruitment to new blood vessels. This involves cooperation between two types of receptor called PDGF receptor and neuropilin-1 that respond to growth factors called PDGF and VEGF-A arriving at the cell surface, as well as sensing close proximity to other cells that make up the blood vessel.

As well as offering insights into the use of ASCs for tissue repair therapies, a better knowledge of how blood vessels develop is crucial to understanding and treating a huge range of diseases such as cancer, diabetic retinopathy and cardiovascular disease.

Professor Kielty said: What we have shown is that adult stem cells respond in particular ways to some of the chemical signals in the body. The next stage will be to understand how this messaging system regulates relocation of the MSCs and instructs them to become blood vessel cells. After that, we can look at applying our understanding to develop stem-cell derived therapies for tissue repair.


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Contact: Matt Goode
matt.goode@bbsrc.ac.uk
01-793-413-299
Biotechnology and Biological Sciences Research Council
Source:Eurekalert

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