Navigation Links
Scientists uncover strong support for once-marginalized theory on Parkinson's disease
Date:4/25/2012

University of California, San Diego scientists have used powerful computational tools and laboratory tests to discover new support for a once-marginalized theory about the underlying cause of Parkinson's disease.

The new results conflict with an older theory that insoluble intracellular fibrils called amyloids cause Parkinson's disease and other neurodegenerative diseases. Instead, the new findings provide a step-by-step explanation of how a "protein-run-amok" aggregates within the membranes of neurons and punctures holes in them to cause the symptoms of Parkinson's disease.

The discovery, published in the March 2012 issue of the FEBS Journal, describes how α-synuclein (a-syn), can turn against us, particularly as we age. Modeling results explain how α-syn monomers penetrate cell membranes, become coiled and aggregate in a matter of nanoseconds into dangerous ring structures that spell trouble for neurons.

"The main point is that we think we can create drugs to give us an anti-Parkinson's effect by slowing the formation and growth of these ring structures," said Igor Tsigelny, lead author of the study and a research scientist at the San Diego Supercomputer Center and Department of Neurosciences, both at UC San Diego.

Familial Parkinson's disease is caused in many cases by a limited number of protein mutations. One of the most toxic is A53T. Tsigelny's team showed that the mutant form of α-syn not only penetrates neuronal membranes faster than normal α-syn, but the mutant protein also accelerates ring formation.

"The most dangerous assault on the neurons of Parkinson's patients appears to be the relatively small α-syn ring structures themselves," said Tsigelny. "It was once heretical to suggest that these ring structures, rather than long fibrils found in neurons of people having Parkinson's disease, were responsible for the symptoms of the disease; however, the ring theory is becoming
'/>"/>

Contact: Rex Graham
ragraham@ucsd.edu
858-232-2706
University of California - San Diego
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Scientists develop new technique that could improve heart attack prediction
2. Scientists advance field of research with publication of newly validated method for analyzing flavanols in cocoa
3. Scripps research scientists find anticonvulsant drug helps marijuana smokers kick the habit
4. Scientists have discovered genes that increase the risk of osteoporosis and fractures
5. Marine scientists urge government to reassess oil spill response
6. Scientists find Achilles heel in life-threatening malaria parasites
7. Scientists find that neurological changes can happen due to social status
8. Scientists discover switch in plants to create flowers
9. Merkin Family Foundation to fund next generation of Broad Institute scientists
10. Scripps Research Institute scientists develop antidote for cocaine overdose
11. Scientists trace evolutionary history of what mammals eat
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... 2015 The 10 th International Conference on ... October 22-25, 2015, in Shenzhen , ... celebrating its 10 th anniversary this year. Since its inauguration ... influential annual meetings in the ,omics, fields, and is one ... ICG-10 focuses on recent breakthroughs and advances in ...
(Date:7/27/2015)... SAN JOSE, Calif. , July 27, 2015 ... leading developer of human interface solutions, today announced ... ClearPad ® touchscreen solution for its stylish ... controller for its proven reliability, low power and ... with a wet finger. Huawei designers also required ...
(Date:7/23/2015)... -- Aware, Inc. (NASDAQ: AWRE ), a leading supplier ... its second quarter ended June 30, 2015.  ... a decrease of 33% compared to $6.8 million in the ... of 2015 was $0.3 million, or $0.01 per diluted share, ... in the same period a year ago.  ...
Breaking Biology News(10 mins):The 10th International Conference on Genomics (ICG-10) to Open in October 2Synaptics Touchscreen Solution Powers New Huawei Watch 2Synaptics Touchscreen Solution Powers New Huawei Watch 3Aware, Inc. Reports Second Quarter 2015 Financial Results 2Aware, Inc. Reports Second Quarter 2015 Financial Results 3Aware, Inc. Reports Second Quarter 2015 Financial Results 4Aware, Inc. Reports Second Quarter 2015 Financial Results 5Aware, Inc. Reports Second Quarter 2015 Financial Results 6
... BLOOMINGTON, Ind. -- Compounds used in new flame-retardant ... increasing concentrations, according to a recent study by ... published in the journal Environmental Science & Technology, ... atmospheric samples collected in the Great Lakes region ...
... 2011 Stillbirth is associated with a range of ... start of pregnancy, including prior pregnancy outcomes, ethnicity and ... These findings are the result of the largest population-based ... issue of the Journal of the American Medical ...
... bright, long-lasting, and colorful leaves, are prized throughout ... Florida, where more than 95% of the world,s ... to develop new varieties to satisfy consumer demand. ... Natalia A. Peres from the University of Florida,s ...
Cached Biology News:Study finds increasing atmospheric concentrations of new flame retardants 2Risk of stillbirth associated with factors known early in pregnancy 2
(Date:7/29/2015)... Sanofi, un leader mondial ... pour le premier semestre 2015. Le Directeur Général ... Visionner l,interview vidéo et lire la transcription ... Au sommaire de l,interview :  - ... - Diabète - Praluent ...
(Date:7/29/2015)... SYDNEY , July 29, 2015 US-Australian ... NVGN ) today confirmed it is committed to progressing ... as soon as practicable and to ensure the Company ... Chief Executive Officer, Iain Ross , said the ... including the lead pre-clinical programs, discovery programs and academic ...
(Date:7/29/2015)... Inc. (NYSE: BIOA ) today announced that ... resigned.  The Company has hired Andrew Ashworth , ... 2014, as full time interim CFO and has launched ... Andy Ashworth began his employment today, to overlap ... was the Company,s CFO from September 2011 to December ...
(Date:7/29/2015)...  AsureQuality and Ubiquitome have agreed to collaborate ... food and primary production sectors. The collaboration will ... the Freedom4. AsureQuality provides quality assurance ... shelf for producers, processors and Competent Authorities around ... control and pest management and surveillance programmes. ...
Breaking Biology Technology:Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 2Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 3Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 4Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 5Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 6Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 7Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 8Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 9Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 10BioAmber Announces Change in Chief Financial Officer 2BioAmber Announces Change in Chief Financial Officer 3AsureQuality and Ubiquitome Partner on Applications for Mobile Molecular Food Safety Testing 2
... intuitive, but a coating of reflective metal can actually make ... They have created an invisible, light-detecting device that can "see ... are silicon nanowires covered by a thin cap of gold. ... technique the engineers refer to as tuning the geometries ...
... 21, 2012 Elsevier,s Computers & Graphics announces ... Retrieval which will incorporate the Collage Authoring Environment, a workflow ... the 2011 Executable Paper Grand Challenge. The call for submissions ... May 13, during the 3DOR Workshop. Collage Authoring ...
... Conn., May 21, 2012  HistoRx, the leader in ... AQUA technology to assessment of messenger RNA in ... of protein in tissue specimens; this new work ... to quantification of nucleic acids.  ...
Cached Biology Technology:Cloak of invisibility: Engineers use plasmonics to create an invisible photodetector 2Cloak of invisibility: Engineers use plasmonics to create an invisible photodetector 3AQUA® Technology Uses Extend Beyond Protein: Effective measurement of messenger RNA now demonstrated 2AQUA® Technology Uses Extend Beyond Protein: Effective measurement of messenger RNA now demonstrated 3
Low melting point. Ideally suited for in gel enzymatic reactions. Gelling temp. 24-28C Melting temp. 65C. EEO 0.12 Resolution 0.5-20 kb; Rnase/Dnase: none detected....
...
QPRT Immunogen: QPRT (NP_055113, 198 a.a. ~ 298 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
...
Biology Products: