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Scientists uncover role for cell scaffold in tumor formation
Date:6/6/2011

orkie, free to act on the DNA in the nucleus, turning on proliferation genes.

The cytoskeleton serves several functions in a cell: it provides structure, motility (allows cells to move, change shape and divide) and membrane traffic (transport of proteins and other large molecules within the cell). The actin protein forms cables that crisscross the cell. The cables are constantly being elongated and shortened at their ends. The actin-capping proteins are involved in this process.

In Florence's words, ' What we've revealed is that the cytoskeleton needs to be very tightly regulated within the cell, to prevent abnormal growth in the larvae. Since Hippo is also turned on in the adult and in mammals, we believe these findings provide insights into how this process may be manipulated in human cells, with a view to preventing tumour formation, or blocking its progression'.


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Contact: Ana Godinho
agodinho@igc.gulbenkian.pt
351-214-407-952
Instituto Gulbenkian de Ciencia
Source:Eurekalert  

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