Navigation Links
Scientists uncover role for cell scaffold in tumor formation
Date:6/6/2011

A group of scientists at the Instituto Gulbenkian de Cincia, in Portugal, have uncovered a surprising link between the cell's skeleton and organ size. The team, led by Florence Janody, show in the journal Development(*), that one of the proteins that regulates the skeleton of the cell also acts to blocks activation of genes that promote cell survival and proliferation. Their findings have implications for cancer research, as they add to the puzzle of understanding how proliferation genes are abnormally activated, often leading to tumours.

During development of an embryo, cells proliferate and organs grow. This process is tightly regulated, at several levels, to ensure that organs do not outgrow the body they are in. One of the key regulators in this process is the Hippo complex of proteins - first identified in the fruit fly Drosophila melanogaster. Mutant flies, in which this complex is defective are larger than their counterparts - they are hippopotamus-like. A search for analogous genes uncovered a similar role for the Hippo complex in mammals - organs grow larger than they should. In adults, this abnormal and untimely growth often leads to tumour formation.

A flurry of papers has shown that the Hippo complex itself is regulated by a range of signaling inputs within the cell. Florence Janody's group identified a new, and unexpected input: the cell skeleton (called cytoskeleton), in particular one of its proteins, the actin-capping protein.

Using Drosophila larvae, the IGC team showed that when the actin-capping proteins are inactive, there is overgrowth of tissue in the area that will become the adult wing. This growth is reminiscent of tumour formation. The researchers dissected the different steps in the process that lead to abnormal growth. Inactivating actin-capping proteins leads to accumulation of actin, a major component of the cytoskeleton; this reduces the activity of the Hippo complex, leaving another protein, Y
'/>"/>

Contact: Ana Godinho
agodinho@igc.gulbenkian.pt
351-214-407-952
Instituto Gulbenkian de Ciencia
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Scientists use super microscope to pinpoint body’s immunity switch
2. Scripps Research scientists find way to block stress-related cell death
3. Scripps Research scientists find key mechanism in transition to alcohol dependence
4. Harvard scientists see the early cellular cause of dry eye disease for the first time
5. Scientists crack the spiders web code
6. Scientists discover fossil of giant ancient sea predator
7. Scientists discover the largest assembly of whale sharks ever recorded
8. Syracuse University scientists discover new hitch to link nerve cell motors to their cargo
9. Scientists list top 10 new species
10. Scientists find new drug target in breast cancer
11. Wildlife in trouble from oil palm plantations, according to scientists
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists uncover role for cell scaffold in tumor formation 
(Date:8/10/2015)... , August 10, 2015 The latest ... offers comprehensive analysis of the global border security market ... revenues of $16.4bn in 2015. Now: Border security ... an example of the business critical issue you need to ... visiongain ,s objective analysis of how this will impact ...
(Date:8/5/2015)... York , August 5, 2015 ... report titled "Facial Recognition Market - Global Industry Analysis, ... the global market for facial recognition is forecast to ... driven by increased demand for surveillance systems by civil ... rising number of crimes and terrorist activities across the ...
(Date:7/31/2015)... , Kina, 31. juli 2015 Den ... bliver afholdt af BGI fra den 22. - 25. oktober ... Konferencen fejrer sin 10-års fødselsdag i år. Siden ... mest indflydelsesrige årlige møder på ,omik,-feltet, og er en ... ICG-10 fokuserer på nylige gennembrud og ...
Breaking Biology News(10 mins):Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 2Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 3Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 4Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 5Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 6Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 7Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 8Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 9Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 2Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 3Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 4Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 5Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 6Den 10. internationale konference om Genomics (ICG-10) åbner i oktober 2
... research discovery published online in the FASEB Journal ... treatment of diabetes. That,s because scientists have moved closer ... than managing its symptoms. Specifically researchers identified a protein ... prevent the death and promote the growth of cells ...
... As it turns out, children were not the only ones ... this past holiday season. In a new research report published ... Leukocyte Biology ( http://www.jleukbio.org ), a team of scientists ... for Children show how a compound from licorice root (glycyrrhizin ...
... DALLAS Jan. 4, 2010 An experimental drug ... in fighting the brain cancer glioblastoma and prostate cancer, researchers ... studies. The drug,s actions, observed in isolated human cells ... especially encouraging because they attacked not only the bulk of ...
Cached Biology News:New discovery by Harvard scientists aims to correct cellular defects leading to diabetes 2A trip to the candy store might help ward off rare, but deadly infections 2Experimental drug shows promise against brain, prostate cancers 2
(Date:8/27/2015)... 2015 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ("Biorem" or "the Company") ... June 30, 2015. Biorem,s complete second quarter financial statements and MD&A ... HIGHLIGHTS: in ,000,s except earnings per shareThree-months ended , Six -months endedJune ... 2015 , 2014 Revenue , 4,709 ... Gross profit , 1,656 , 56 , ...
(Date:8/27/2015)... Aug. 27, 2015 In response to ... UPS and The US Postal Service to no ... as ,select agents, by the CDC, Marken reaffirmed ... these sensitive shipments. Marken uses its ... trained and certified personnel to ensure the safe ...
(Date:8/26/2015)... ... August 26, 2015 , ... Lee Biosolutions, a global biotech ... manufacture of highly valued cardiac markers used in early detection of heart disease ... chemistry has led to the development and commercialization of important cardiac biomarkers used ...
(Date:8/26/2015)... , Aug. 26, 2015 China Cord Blood ... China,s leading provider of cord blood collection, ... storage services, today announced that the Company has been ... an entity wholly owned by Mr. Yuen Kam, chairman ... acquired the outstanding shares (the "Shares") of  Excellent China ...
Breaking Biology Technology:BIOREM Reports $718,000 Net Earnings for the Second Quarter 2BIOREM Reports $718,000 Net Earnings for the Second Quarter 3Marken Ensures Safe Transportation Of Select Agents And Toxins 2Lee Biosolutions Announces Increased Investment in the Development and Manufacturing of Biomarkers Used in Early Detection Of Heart Disease 2China Cord Blood Corporation Receives Notice of Transactions Regarding its 7% Senior Convertible Notes Due 2017 2China Cord Blood Corporation Receives Notice of Transactions Regarding its 7% Senior Convertible Notes Due 2017 3
... , CAMBRIDGE, Mass., July 6 /PRNewswire-FirstCall/ -- Verenium ... agreement to amend the $29.5 million of outstanding 8% Senior ... and announced on July 1, 2009 is effective as of ... Note Amendment Agreements with holders of 87% of the Notes, ...
... , HONG KONG, July 6 ... will have direct access to Filligent,s patented anti-,microbial face ... germs like H1N1 upon contact, was launched at Asia,s ... travel agency, Hong,Thai, will be providing the BioMask(TM), on ...
... ST PETER PORT, Guernsey and LONDON, July ... Funding to Drive Novel Antibiotics Platform Addressing,Areas of Major Unmet ... Celtic Pharma Holdings Advisors LLP ("CPHA"), the ... LP ("CP2"), today announces its,investment in a majority shareholding in ...
Cached Biology Technology:Verenium Completes Amendment to 8% Senior Convertible Notes 2Verenium Completes Amendment to 8% Senior Convertible Notes 3Verenium Completes Amendment to 8% Senior Convertible Notes 4High-Tech 'Smart' Face Mask Helps Hong Kong Families Combat Swine Flu 2High-Tech 'Smart' Face Mask Helps Hong Kong Families Combat Swine Flu 3High-Tech 'Smart' Face Mask Helps Hong Kong Families Combat Swine Flu 4High-Tech 'Smart' Face Mask Helps Hong Kong Families Combat Swine Flu 5Celtic Pharma Holdings Announces Investment in Novacta Biosystems Limited 2Celtic Pharma Holdings Announces Investment in Novacta Biosystems Limited 3Celtic Pharma Holdings Announces Investment in Novacta Biosystems Limited 4Celtic Pharma Holdings Announces Investment in Novacta Biosystems Limited 5
Mouse monoclonal antibody raised against a partial recombinant CHD8. NCBI Entrez Gene ID = CHD8...
... antibody raised against a partial ... Immunogen: TOPORS (NP_005793, 98 ... recombinant protein with GST tag. ... NM_005802 ...
Mouse monoclonal antibody raised against a partial recombinant DENR. NCBI Entrez Gene ID = DENR...
Mouse monoclonal antibody raised against a full length recombinant SNAPC5. NCBI Entrez Gene ID = SNAPC5...
Biology Products: