Navigation Links
Scientists uncover previously unknown mechanism of memory formation
Date:1/30/2013

JUPITER, FL, January 30, 2013 It takes a lot to make a memory. New proteins have to be synthesized, neuron structures altered. While some of these memory-building mechanisms are known, many are not. Some recent studies have indicated that a unique group of molecules called microRNAs, known to control production of proteins in cells, may play a far more important role in memory formation than previously thought.

Now, a new study by scientists on the Florida campus of The Scripps Research Institute has for the first time confirmed a critical role for microRNAs in the development of memory in the part of the brain called the amygdala, which is involved in emotional memory. The new study found that a specific microRNAmiR-182was deeply involved in memory formation within this brain structure.

"No one had looked at the role of microRNAs in amygdala memory," said Courtney Miller, a TSRI assistant professor who led the study. "And it looks as though miR-182 may be promoting local protein synthesis, helping to support the synapse-specificity of memories."

In the new study, published in the Journal of Neuroscience, the scientists measured the levels of all known microRNAs following an animal model of learning. A microarray analysis, which enables rapid genetic testing on a large scale, showed that more than half of all known microRNAs are expressed in the amygdala. Seven of those microRNAs increased and 32 decreased when learning occurred.

The study found that, of the microRNAs expressed in the brain, miR-182 had one of the lowest levels and these decreased further with learning. Despite these very low levels, its overexpression prevented the formation of memory and led to a decrease in proteins that regulate neuronal plasticity (neurons' ability to adapt) through changes in structure.

These findings suggest that learning-induced suppression of miR-182 is a main supporting factor in the formation of long-term memory in the amagdala, as well as an underappreciated mechanism for regulating protein synthesis during memory consolidation, Miller said.

Further analysis identified miR-182 as a repressor of proteins that control actina major component of the cytoskeleton, the scaffolding that holds cells together.

"We know that memory formation requires changes in dendritic spines on the neurons through regulation of the actin cytoskeleton," Miller said. "When miR-182 is suppressed through learning it halts, at least in part, repression of actin-regulating proteins, so there's a good chance that miR-182 exerts important control over the actin cytoskeleton."

Miller is now interested in whether or not high levels of miR-182 accumulate in the aging brain, something that would help to explain a tendency toward memory loss in the elderly. She also notes that other research has shown that animal models lacking miR-182 had no significant physical or cellular abnormalities, suggesting that miR-182 could be a viable target for drug discovery.


'/>"/>
Contact: Eric Sauter
esauter@scripps.edu
267-337-3859
Scripps Research Institute
Source:Eurekalert  

Related biology news :

1. Stanford scientists develop gene therapy approach to grow blood vessels in ischemic limbs
2. Queens scientists seek vaccine for Pseudomonas infection
3. Scientists produce eye structures from human blood-derived stem cells
4. American Society of Plant Biologists honors early career women scientists
5. Brandeis scientists win prestigious prize for circadian rhythms research
6. Scientists discover new method of proton transfer
7. Salk scientists open new window into how cancers override cellular growth controls
8. WileyChina.com - Now Featuring Bespoke Pages for China’s Life Scientists
9. Scientists win $2 million to study new pathway in development and maintenance of lymphoma
10. UGA scientists reveal genetic mutation depicted in van Goghs sunflower paintings
11. Genetic mutation depicted in van Goghs sunflower paintings revealed by scientists
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists uncover previously unknown mechanism of memory formation
(Date:3/30/2017)... KONG , March 30, 2017 The ... a system for three-dimensional (3D) fingerprint identification by adopting ground breaking ... into a new realm of speed and accuracy for use in ... at an affordable cost. ... ...
(Date:3/24/2017)... , March 24, 2017 The Controller General of ... Mr. Abdulla Algeen have received the prestigious international IAIR Award ... Continue Reading ... ... and Deputy Controller Abdulla Algeen (small picture on the right) have received ...
(Date:3/22/2017)... YORK , March 21, 2017 ... Marketing Cloud used by retailers such as 1-800-Flowers ... its platform — Product Recommendations and Replenishment. Using Optimove,s ... give more personalized product and replenishment recommendations to ... but also on predictions of customer intent drawn ...
Breaking Biology News(10 mins):
(Date:6/19/2017)... (PRWEB) , ... June 19, 2017 , ... ... solutions for clinical development reported today that it is launching two new additions ... company will be demonstrating new capabilities at the DIA 2017 Annual Meeting in ...
(Date:6/16/2017)... ... , ... CTNext , Connecticut’s go-to resource for entrepreneurial support, today announced ... Chelsea Piers in Stamford. , Nine finalists, all of whom are Connecticut-based companies and ... to secure $10,000 awards to help support business growth. The winners included:, ...
(Date:6/15/2017)... ... 2017 , ... DuPont Industrial Biosciences (DuPont) announced that Jan ... Bloomberg’s 2017 Sustainable Business Summit: Seattle this Thursday, June 15, at 4:10 ... panel titled “Developing a Corporate Renewables Strategy.” , “Consumers want to buy ...
(Date:6/14/2017)... ... ... Diagenode, a leading global provider for complete solutions for ... technology specific for ChIP-sequencing from the CeMM for low ... (ChIP-seq) allows the study of histone modifications and transcription ...
Breaking Biology Technology: