Navigation Links
Scientists uncover novel mechanism of glioblastoma development
Date:1/17/2012

PHILADELPHIA Most research on glioblastoma development, a complicated tumor of the brain with a poor prognosis, has focused on the gene transcription level, but scientists suggest that post-transcriptional regulation could be equally or even more important.

In a recent report in Molecular Cancer Research, a journal of the American Association for Cancer Research, scientists led by Luiz O. F. Penalva, Ph.D., an assistant professor in the department of cellular and structural biology at the University of Texas Health Science Center at San Antonio, illustrated that the connection between two RNA-binding proteins, Musashi1 and HuR, can have important consequences to glioblastoma.

"This is a novel finding in terms of what we know about glioblastoma development," said Penalva. "Most of what we know about glioblastoma is limited to gene transcription-level research, but there are other regulatory processes beyond transcription that when disrupted could contribute to tumor formation."

RNA-binding proteins are key regulators in all cellular processes from splicing to translation. Changes that affect either their function or expression levels can have dramatic consequences to protein production and can lead to disease states including cancer.

In the lab, Penalva and his colleagues showed that increased levels of HuR up-regulate the expression of another RNA-binding protein, Musashi1. Both proteins control the expression of cancer-related genes; their interaction brings together two important gene networks with major consequences to glioblastoma development.

The results are still early, but Penalva stressed that little is known about glioblastoma development and the findings represent a move toward greater understanding.

"To treat cancer, you have to understand what triggers tumor formation," said Penalva. "If we continue to think that all the activity is at the transcription level, we are just fooling ourselves. Clearly, something is going on beyond that level."


'/>"/>

Contact: Jeremy Moore
Jeremy.Moore@aacr.org
215-446-7109
American Association for Cancer Research
Source:Eurekalert

Related biology news :

1. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
2. Scientists identify novel inhibitor of human microRNA
3. Argonne scientists peer into heart of compound that may detect chemical, biological weapons
4. MU scientists go green with gold, distribute environmentally friendly nanoparticles
5. Scientists identify gene that may contribute to improved rice yield
6. Scientists discover why a mothers high-fat diet contributes to obesity in her children
7. MU scientists see how HIV matures into an infection
8. Earth scientists keep an eye on Texas
9. Thinking it through: Scientists call for policy to guide biofuels industry toward sustainability
10. Scientists identify a molecule that coordinates the movement of cells
11. Scientists Find new migratory patterns for Mediterranean and Western Atlantic bluefin tuna
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2017)... 24, 2017 Janice Kephart , ... Identity Strategy Partners, LLP (IdSP) , today issues ... President Trump,s March 6, 2017 Executive Order: ... vetting can be instilled with greater confidence, enabling ... all refugee applications are suspended by until at ...
(Date:4/13/2017)... Calif. , April 13, 2017 UBM,s ... York will feature emerging and evolving technology ... Both Innovation Summits will run alongside the expo portion ... speaker sessions, panels and demonstrations focused on trending topics ... largest advanced design and manufacturing event will take place ...
(Date:4/11/2017)... BROOKLYN, N.Y. , April 11, 2017 /PRNewswire-USNewswire/ ... identical fingerprints, but researchers at the New York ... University College of Engineering have found that partial ... fingerprint-based security systems used in mobile phones and ... previously thought. The vulnerability lies in ...
Breaking Biology News(10 mins):
(Date:9/20/2017)... ... 20, 2017 , ... Proscia Inc. , a data ... of whole slide imaging solutions, are hosting a pre-conference workshop at the ... a Best-in-Class Strategy for Digital Pathology,” will feature Proscia CEO, David West Jr., ...
(Date:9/20/2017)... ... September 20, 2017 , ... RoviSys, a leading ... today the opening of an office in Taipei, Taiwan. This new location allows ... while developing new relationships in the region. Located in the Neihu area of ...
(Date:9/19/2017)... Poway, CA (PRWEB) , ... September 19, 2017 , ... VetStem Biopharma ’s CEO ... H. Riordan PA, PhD in Riordan’s new book "Stem Cell Therapy: A Rising Tide". ... past 14 years. They bonded over an interest in the potential of stem cell ...
(Date:9/19/2017)... ... September 19, 2017 , ... Avomeen Analytical Services, ... of its 2017 Science Student Award. The scholarship program is dedicated to helping ... service defray the costs of obtaining their science education. , Avomeen began the ...
Breaking Biology Technology: