Navigation Links
Scientists uncover new genetic variations linked to psoriasis
Date:1/26/2009

Two international teams of researchers have made significant gains in understanding the genetic basis of psoriasis, a chronic skin condition that can be debilitating in some patients. Their research, involving thousands of patients, is reported in two studies published this week in the advance online Nature Genetics.

"Taken together, the studies help us get closer to realizing the promise of personalized medicine," says a senior author of both papers, Anne Bowcock, Ph.D., professor of genetics at Washington University School of Medicine in St. Louis. "Eventually, we hope to be able target treatments to psoriasis patients based on the genetic alterations that have contributed to their disease."

The researchers found a number of new genetic variants that affect an individual's risk of psoriasis. Their discoveries point to different biological pathways that underlie the disease and may eventually lead to targeted drugs and treatments that hit specific pathways, Bowcock says.

An estimated 7 million Americans have psoriasis, an autoimmune disease that occurs when the body's immune cells mistakenly attack the skin. The condition is usually characterized by red, scaly skin patches that can be itchy, painful or both. Some 10 to 30 percent of patients with psoriasis develop psoriatic arthritis, which occurs when inflammation attacks the joints, causing pain and disability.

Both of the new studies looked for common variants in the genomes of psoriasis patients to uncover associations with the disease.

The first study, conducted in collaboration with the University of Michigan, the University of Utah and colleagues in Canada and Europe, focused on sites within the genome where a single unit of DNA is changed, called a single nucleotide polymorphism (SNP). The researchers scanned nearly 450,000 SNPs in each of the genomes of 1,409 psoriasis patients and compared the DNA variations to those in 1,436 healthy controls.

They initially discovered 21 suspect variants associated with psoriasis. Going one step further, the investigators tested the validity of these variants in another group of 5,048 psoriasis patients and 5,041 controls. This revealed a shorter list of confirmed variants seven all of which appear to increase the risk of the disease. Five of the variants cluster in two distinct pathways that involve the signaling molecules IL-23 and NF-kappaB.

A second study of 2,831 patients with psoriasis looked for links between the disease and copy number variations, in which a gene is produced in multiple copies. Bowcock and her colleagues in Barcelona, Spain and elsewhere found that the absence of two skin genes LCE3B and LCE3C increases the risk of psoriasis.

Both genes normally are activated after an injury to the skin. The researches suspect the absence of the genes could lead to an inappropriate immune response, which may cause the inflammation that is a hallmark of the disease.

"Until now, all of the genes linked to psoriasis have been involved in the immune system," Bowcock says. "But psoriasis is a disease of the immune system and the skin, and it makes sense that we would eventually find genes in the skin that are involved in the disease."

The new variants uncovered by the researchers each make only a small contribution to the overall genetic risk of the psoriasis. Patients usually have a number of different genetic variations that increase their risk of the disease.

Also, Bowcock noted that some of the newly discovered variants have been associated with other inflammatory diseases such as Crohn's disease and autoimmune diseases like rheumatoid arthritis and lupus. Additional studies will help to tease apart the ways in which these diseases are connected at the level of DNA. This information will also aid in the search for more targeted drugs that can zero in on particular genetic defects that cause the diseases.


'/>"/>

Contact: Caroline Arbanas
carbanas@aol.com
314-286-0109
Washington University School of Medicine
Source:Eurekalert

Related biology news :

1. 3 new informatics pilot projects to aid clinical and translational scientists nationwide
2. Scientists identify bacteria that increase plant growth
3. Scientists use lasers to measure changes to tropical forests
4. Scientists unlock possible aging secret in genetically altered fruit fly
5. Jefferson scientists discover a key protein regulator of inflammation and cell death
6. MUHC and McGill scientists explain genetic disease first discovered in Quebec 24 years ago
7. Scientists uncover evolutionary keys to common birth disorders
8. Invasive plants challenge scientists in face of environmental change
9. Key to future medical breakthroughs is systems biology, say leading European scientists
10. Scripps scientists develop first examples of RNA that replicates itself indefinitely
11. Florida professor creates endowment for insect scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2016)... , April 14, 2016 ... and Malware Detection, today announced the appointment of ... the new role. Goldwerger,s leadership appointment comes ... the heels of the deployment of its platform at ... behavioral biometric technology, which discerns unique cognitive and physiological ...
(Date:3/31/2016)... Florida , March 31, 2016 ... ) ("LegacyXChange" or the "Company") LegacyXChange ... potential users of its soon to be launched online ... ( https://www.youtube.com/channel/UCyTLBzmZogV1y2D6bDkBX5g ) will also provide potential ... use of DNA technology to an industry that is ...
(Date:3/29/2016)... RATON, Florida , March 29, 2016 ... or the "Company") LegacyXChange "LEGX" and SelectaDNA/CSI Protect are ... DNA in ink used in a variety of writing ... theft. Buyers of originally created collectibles from athletes on ... through forensic analysis of the DNA. ...
Breaking Biology News(10 mins):
(Date:6/23/2016)...   Boston Biomedical , an industry leader ... target cancer stemness pathways, announced that its lead ... Designation from the U.S. Food and Drug Administration ... gastroesophageal junction (GEJ) cancer. Napabucasin is an orally ... stemness pathways by targeting STAT3, and is currently ...
(Date:6/23/2016)...  The Prostate Cancer Foundation (PCF) is pleased to announce 24 ... for prostate cancer. Members of the Class of 2016 were selected from a ... Read More About the Class of 2016 PCF Young Investigators ... ... ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... In a ... Hospital in Denmark detail how a patient who developed lymphedema after being treated for ... The results could change the paradigm for dealing with this debilitating, frequent side effect ...
(Date:6/23/2016)... ... June 23, 2016 , ... ClinCapture, the only ... Center and will showcase its product’s latest features from June 26 to June ... scientific poster on Disrupting Clinical Trials in The Cloud during the conference. ...
Breaking Biology Technology: