Navigation Links
Scientists uncover new class of non-protein coding genes in mammals with key functions
Date:2/1/2009

ecies, suggesting that they may simply be 'genomic noise' without any biological function."

To uncover this large collection of new genes, the Broad scientific team looked not at the RNA molecules themselves but at telltale signs in the DNA called chromatin modifications or epigenomic marks. They searched for genomic regions that have the same chromatin patterns as protein-coding genes, but do not encode proteins. By surveying the genomes of four different types of mouse cells (including embryonic stem cells and cells from various tissue types), they found an astounding 1,586 such loci that had not been previously described. The researchers also found that the vast majority of these genomic regions are transcribed into lincRNAs, and that these are conserved across mammals.

"The epigenomic marks revealed where these genes were hiding," said Mitch Guttman, a MIT graduate student working at the Broad Institute. "Analysis of their sequence then revealed that the genes are highly conserved in mammalian genomes, which strongly suggested that these genes play critical biological functions."

By correlating the expression patterns of lincRNAs in various cell types with the expression patterns of known critical protein-coding genes in those same cells, the scientists observed that lincRNAs likely play critical roles in helping to regulate a variety of different cellular processes, including cell proliferation, immune surveillance, maintenance of embryonic stem cell pluripotency, neuronal and muscle development, and gametogenesis. Further experimental evidence from several of the identified lincRNAs verified these observations.

Because of the stringent experimental conditions imposed by the researchers in identifying the 1,600 lincRNAs in the Nature study, it is likely that there are many more lincRNA genes hiding in plain sight in the genome, as well as other RNA-encoding genes that are as important to genome function as their better-recog
'/>"/>

Contact: Nicole Davis
ndavis@broad.mit.edu
617-258-0952
Broad Institute of MIT and Harvard
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UK scientists working to help cut ID theft
2. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
3. Comet probes reveal evidence of origin of life, scientists claim
4. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
5. Male elephants get photo IDs from scientists
6. Scientists retrace evolution with first atomic structure of an ancient protein
7. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
8. Carnegie Mellon scientists develop nanogels that enable controlled delivery of carbohydrate drugs
9. Clemson scientists shed light on molecules in living cells
10. Scientists tackle mystery mountain illness
11. T. rex quicker than Becks, say scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... wrong with your muscles because of age, disease or injury, ... That,s where a new research report published in the October ... comes in. In the report, a team of scientists produce ... scientists "see" which genes are active in an organ at ... and that men have approximately 400 more active genes in ...
(Date:9/30/2014)... MILFORD, Mass. , Sept. 30, 2014 ... process control solutions for the biotech and ... of its new RECONN Bioprocess Manager, an ... reporting solution geared towards bioprocess development laboratories. ... facilities have disparate bioreactor and analyzer systems. ...
(Date:9/30/2014)... Sept. 30, 2014 Winners of The Economist,s ... Summit scheduled to take place at the JW Marriott Hong Kong ... award winners will share their experiences and the lessons those hold ... a proven innovation over the past decade, will be presented at ... before the summit. It will be the first time the ceremony ...
Breaking Biology News(10 mins):Scientists identify which genes are active in muscles of men and women 2Spectra Automation Introduces RECONN Bioprocess Manager 2Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 2Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 3Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 4Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 5Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 6Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 7
... A recent report in Cancer Epidemiology, Biomarkers & Prevention ... adds to the growing evidence that fish oil supplements may ... at the Fred Hutchinson Cancer Research Center in Seattle, Wash., ... health sciences division, asked 35,016 postmenopausal women who did not ...
... combat some age-related diseases, such as cancer and diabetes, ... and cellular processes governing aging. The underlying theory is ... span can be extended, it may delay the onset ... these molecular processes, researchers at the University of Massachusetts ...
... engineers at Purdue University have developed a new method ... and they are proposing the creation of mobile processing ... fuels. "What,s important is that you can ... chips, switch grass, corn stover, rice husks, wheat straw ...
Cached Biology News:Fish oil may reduce risk of breast cancer 2Biologists identify a new clue into cellular aging 2New biofuels processing method for mobile facilities 2New biofuels processing method for mobile facilities 3
(Date:10/1/2014)... October 01, 2014 Slone Partners ... Therapeutics, Healthcare IT, and Laboratory Testing industries, reported a ... at the director level and above from July 2013 ... stay on top of rapid breakthroughs in diagnostics, reimbursement ... diagnostic companies have been forced to fold, consolidate, or ...
(Date:10/1/2014)... -- Industry leaders from retail pharmacies ... the theme, ,Commercial Opportunities in the Era of Reform, ... Elsevier , a world-leading provider of scientific, technical ... gathering of some of the industry,s most prominent healthcare ... and in the future. The Elsevier Healthcare ...
(Date:9/30/2014)... a bio-mimicking analog of one of nature,s most ... research team led by Alejandro Briseno of the ... step in developing long-sought polymer architecture to boost ... in electronic devices. , Briseno, with colleagues ... at Stanford University and Dresden University of Technology, ...
(Date:9/30/2014)... YORK , Sept. 30, 2014 ... to kill nematodes. Nematodes are microscopic parasitic roundworms, ... water, and inside other plants and animals. Nematicides ... volatility or other properties promoting migration through the ... more than 1,000 plant-parasitic nematodes. With more than ...
Breaking Biology Technology:Slone Partners Meets Growing Demand as Industry Focuses on Reimbursement & Regulation 2Elsevier Healthcare and Pharmaceutical Economics Conference 2014 To Convene Industry Leaders to Discuss Top Healthcare Business Issues 2Elsevier Healthcare and Pharmaceutical Economics Conference 2014 To Convene Industry Leaders to Discuss Top Healthcare Business Issues 3Blades of grass inspire advance in organic solar cells 2Blades of grass inspire advance in organic solar cells 3Nematicides Market by Types (Fumigants, Organophosphates, Carbamate and Bio-Nematicides), Applications (Agrochemicals, Industrial, and Others), and Geography (North America, Europe, Asia-Pacific & ROW) - Global Trends & Forecasts to 2019 2
... DD ),today announced the addition of Deepak ... Biotechnology Advisory Panel. They join the ranks of,six ... to the,broad area of biotechnology and its application ... a professor of Genetics and Vice Chancellor for ...
... will help commercialize innovative technologies for early lung ... ... Inc. (OTC,Bulletin Board: BMOD) ( http://www.biomoda.com ), a development stage medical,diagnostics ... Lambros, and Lewis White, to its Board of,Directors. The Board Members, ...
... 5 /PRNewswire-FirstCall/ - Spectral Diagnostics Inc. (TSX:,SDI) today ... Toray,Medical Co. Ltd. for the marketing and sale ... cleared assay for the measurement of,endotoxin. Under the ... access to Toray,s distributors in new geographic territories,including ...
Cached Biology Technology:DuPont Strengthens Commitment to Responsible Science with New Biotech Advisory Panel Members 2DuPont Strengthens Commitment to Responsible Science with New Biotech Advisory Panel Members 3Biomoda Appoints Three Business Leaders to Board of Directors 2Biomoda Appoints Three Business Leaders to Board of Directors 3Spectral and Toray expand collaboration to include new geographic territories 2Spectral and Toray expand collaboration to include new geographic territories 3
Goat polyclonal to HA1 ( Abpromise for all tested applications). Antigen: Synthetic peptide: TLGSCRERQPEFV from the C terminus of human HA1. Entrez GeneID: 23526 Swiss Protein ID: O78181...
... Capture high-resolution chemiluminescent and bioluminescent ... High-sensitivity camera is cooled to subzero ... dynamic range for high quality images ... light-tight cabinet provides optimum conditions for ...
Goat polyclonal to Sarcosine Oxidase ( Abpromise for all tested applications). Antigen: Microbial Sarcosine Oxidase. Entrez Gene ID: 51268 Swiss Protein ID: Q6IAJ9...
odz, odd Oz/ten-m homolog 1 [Source:RefSeq_peptide;Acc:NP_055068] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
Biology Products: