Navigation Links
Scientists uncover how hormones achieve their effects
Date:10/22/2007

New insights into the cellular signal chain through which pheromones stimulate mating in yeast have been gained by scientists at the European Molecular Biology Laboratory (EMBL). Similar signal chains are found in humans, where they are involved in many important processes such as the differentiation of nerve cells and the development of cancer. A sophisticated microscopy technique allowed the researchers to observe for the first time the interplay of signalling molecules in living yeast cells, and to work out how they pass on a signal through the cell. The results are published in the current issue of Nature Cell Biology.

Upon release of a pheromone a chemical signal stimulating mating behaviour - by a nearby cell, yeast cells form a projection that serves as a mating organ and brings about the fusion of two cells. The pheromone binds to a receptor on the cells exterior in the same way as many growth hormones in humans do which then sets off a signalling chain inside the cell. This chain consists of a series of proteins called MAP kinases, which pass on the signal by interacting with each other and activating the next downstream member of the chain by adding on phosphate residues. At the end of the chain are those molecules that bring about the changes that underpin the formation of the mating organ and the fusion of the cells.

Scientists in the groups of Michael Knop and Philippe Bastiaens at EMBL labelled members of the MAP kinase signalling chain with fluorescent molecules and observed their diffusion and interaction in living yeast cells stimulated with pheromones using a novel microscopic approach that does not disturb the natural state of the cell.

Our method is so precise that we could virtually count the molecules and the interactions between chain components, says Knop. To our surprise, the observed proteins in the cells interior did not interact more after stimulation by the pheromone. This means changes in interaction are not the way
'/>"/>

Contact: Anna-Lynn Wegener
wegener@embl.de
0049-622-138-7452
European Molecular Biology Laboratory
Source:Eurekalert

Page: 1 2

Related biology news :

1. Wisconsin scientists grow critical nerve cells
2. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
3. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
4. UAB scientists discover the origin of a mysterious physical force
5. Fox Chase Cancer Center scientists identify immune-system mutation
6. Scientists Replicate Hepatitis C Virus in Laboratory
7. Scientists detect probable genetic cause of some Parkinsons disease cases
8. Scientists find missing enzyme for tuberculosis iron scavenging pathway
9. Scientists seek answers on what activates deadly anthrax spores
10. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
11. Scientists collaborate to assess health of global environment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2014)... NC Seeds that sprout as soon as they,re planted ... need to be more careful. In the wild, a plant ... day would risk disaster. More than just an insurance policy ... that seed dormancy has long-term advantages too: Plants whose ... rise to more species, finds in a team of researchers ...
(Date:4/17/2014)... , Respiratory syncytial virus (RSV) is a ... life-threating illness in very young and elderly populations. ... enters host cells through the fusion protein RSV ... interfering peptides that prevent bundle formation limit RSV ... susceptible to degradation. In this issue of the ...
(Date:4/17/2014)... Gauthier and Professor Luca Razzari of the nergie ... large grants from the John R. Evans Leaders ... for the acquisition of state-of-the-art biotech and nanophotonics ... grants from the Ministre de l,Enseignement suprieur, de ... Technologie (MESRST). These new laboratories will help us ...
Breaking Biology News(10 mins):Plants with dormant seeds give rise to more species 2JCI online ahead of print table of contents for April 17, 2014 2JCI online ahead of print table of contents for April 17, 2014 3JCI online ahead of print table of contents for April 17, 2014 4JCI online ahead of print table of contents for April 17, 2014 5JCI online ahead of print table of contents for April 17, 2014 6New state-of-the-art biotech and nanotech equipment for INRS 2
... bio-based plastic packaging is not only eco-friendly but also ... The plastic packaging industry is moving towards completely bio-based ... the production of plastics equates to approximately five per ... per cent of all plastics are used in packaging, ...
... well-known fairy tale, Rumpelstiltskin used magic to weave straw into ... to turn straw (and other forms of biomass) into today,s ... in which minute particles of gold dot the surface of ... two materials are strong enough to breaks the O-O bond ...
... Software Inc. of Ottawa, Canada announced today it ... lead its company awareness and lead generation campaigns. ... in developing integrated marketing programs that target embedded ... messaging and positioning, PR, content development, partner co-marketing ...
Cached Biology News:Plastic packaging industry is moving towards completely bio-based products 2Gases from grasses 2Gases from grasses 3Crank Software Selects TREW Marketing for Embedded Industry Outreach 2Crank Software Selects TREW Marketing for Embedded Industry Outreach 3
(Date:1/15/2014)... January 15, 2014 This webinar will ... and clinical safety assessment in biosimilars. , Regulatory frameworks ... biosimilar drug development, however the complex nature of biopharmaceuticals ... safety and efficacy extremely challenging. Based on the specific ...
(Date:1/15/2014)... Rochester, NY (PRWEB) January 15, 2014 The ... cause a major disease. One of these latent viruses is ... is rheumatoid arthritis (RA). Rheumatoid arthritis (RA) is a chronic ... the theory, a study found that RA patients have high ...
(Date:1/15/2014)... January 15, 2014 AudioNotch is the ... therapy for the treatment of tinnitus. Patients listen to ... and over a period of weeks to months, their tinnitus ... in two forms: Notched Music and Notched White Noise. Now, ...
(Date:1/14/2014)... Histogen, Inc., a regenerative medicine company developing ... simulated embryonic conditions, today announced that they have entered ... for physician-dispensed aesthetic products containing Histogen’s proprietary multipotent cell ... an amendment to the existing license between Histogen and ...
Breaking Biology Technology:Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3
... Aug. 14 Pressure,BioSciences, Inc. (Nasdaq: PBIO ) ... the second quarter of 2008 was $120,184 compared to,$202,127 ... from the sale,of PCT products and services was $117,698 ... to $136,355 for the prior year period. During the,second ...
... drugs and devices that have ... the quality of human life -, PALO ALTO, Calif., ... announced that its chronic angina therapy,Ranexa(R) (ranolazine extended-releases tablets) has ... 2008 award which honors the,best pharmaceutical agent and best biotechnology ...
... TROY, Mich., Aug. 14 CJPS Enterprises, LLC, ... today that it,has put online more resources for ... market, or to grow their existing healthcare,business. Those ... This project is dedicated to providing users ...
Cached Biology Technology:Pressure BioSciences, Inc. Reports Second Quarter 2008 Financial Results and Provides Business Update 2Pressure BioSciences, Inc. Reports Second Quarter 2008 Financial Results and Provides Business Update 3Pressure BioSciences, Inc. Reports Second Quarter 2008 Financial Results and Provides Business Update 4Pressure BioSciences, Inc. Reports Second Quarter 2008 Financial Results and Provides Business Update 5Pressure BioSciences, Inc. Reports Second Quarter 2008 Financial Results and Provides Business Update 6Pressure BioSciences, Inc. Reports Second Quarter 2008 Financial Results and Provides Business Update 7Pressure BioSciences, Inc. Reports Second Quarter 2008 Financial Results and Provides Business Update 8Pressure BioSciences, Inc. Reports Second Quarter 2008 Financial Results and Provides Business Update 9CV Therapeutics Announces Ranexa(R) Named Finalist for Prix Galien USA 2008 Award 2CV Therapeutics Announces Ranexa(R) Named Finalist for Prix Galien USA 2008 Award 3The Michigan Life Sciences Pipeline Adds More Resources On Its Website 2
... Rabbits x 2 , Maintenance ... x1 /each , Immunizations/Boost injections ... 5 ml) x1 /each , Production ... , Final Bleed ~ 100 ml blood (~50 ...
... 500 g protein in 200 l SDS-PAGE ... cell lysate; Abelson transformed macrophage cells, ... positive control, should be stored ... be minimized, sample vial should ...
muscle actin (HUC1-1)...
...
Biology Products: