Navigation Links
Scientists uncover how hormones achieve their effects
Date:10/22/2007

New insights into the cellular signal chain through which pheromones stimulate mating in yeast have been gained by scientists at the European Molecular Biology Laboratory (EMBL). Similar signal chains are found in humans, where they are involved in many important processes such as the differentiation of nerve cells and the development of cancer. A sophisticated microscopy technique allowed the researchers to observe for the first time the interplay of signalling molecules in living yeast cells, and to work out how they pass on a signal through the cell. The results are published in the current issue of Nature Cell Biology.

Upon release of a pheromone a chemical signal stimulating mating behaviour - by a nearby cell, yeast cells form a projection that serves as a mating organ and brings about the fusion of two cells. The pheromone binds to a receptor on the cells exterior in the same way as many growth hormones in humans do which then sets off a signalling chain inside the cell. This chain consists of a series of proteins called MAP kinases, which pass on the signal by interacting with each other and activating the next downstream member of the chain by adding on phosphate residues. At the end of the chain are those molecules that bring about the changes that underpin the formation of the mating organ and the fusion of the cells.

Scientists in the groups of Michael Knop and Philippe Bastiaens at EMBL labelled members of the MAP kinase signalling chain with fluorescent molecules and observed their diffusion and interaction in living yeast cells stimulated with pheromones using a novel microscopic approach that does not disturb the natural state of the cell.

Our method is so precise that we could virtually count the molecules and the interactions between chain components, says Knop. To our surprise, the observed proteins in the cells interior did not interact more after stimulation by the pheromone. This means changes in interaction are not the way
'/>"/>

Contact: Anna-Lynn Wegener
wegener@embl.de
0049-622-138-7452
European Molecular Biology Laboratory
Source:Eurekalert

Page: 1 2

Related biology news :

1. Wisconsin scientists grow critical nerve cells
2. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
3. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
4. UAB scientists discover the origin of a mysterious physical force
5. Fox Chase Cancer Center scientists identify immune-system mutation
6. Scientists Replicate Hepatitis C Virus in Laboratory
7. Scientists detect probable genetic cause of some Parkinsons disease cases
8. Scientists find missing enzyme for tuberculosis iron scavenging pathway
9. Scientists seek answers on what activates deadly anthrax spores
10. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
11. Scientists collaborate to assess health of global environment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... HUNTSVILLE, TX (4/23/14) -- Researchers have found evidence ... risk factors that increase aggressive behavior in children, ... that not all children exposed to prenatal smoking ... others will not," said Brian Boutwell, Assistant Professor ... Justice and senior author on the study. ...
(Date:4/23/2014)... as an antimicrobial ingredient in soaps, toothpastes and other ... new evidence that appears to support these worries. Their ... in Toxicology , found that triclosan, as well as ... human breast cancer cells in lab dishes and breast ... note that hormonal imbalances seem to play a role ...
(Date:4/23/2014)... study to date of the family of bacteria ... vaccine strategies and reveals surprising findings about the ... alter public health strategies to control this respiratory ... , Genomic analysis of 343 strains of the ... world collected over the last 100 years illustrates ...
Breaking Biology News(10 mins):Genetics risk, prenatal smoking may predict behavioral problems 2In lab tests, the antimicrobial ingredient triclosan spurs growth of breast cancer cells 2Impact of whooping cough vaccination revealed 2
... will present the 2013 William Dameshek Prize to Andrew S. ... research on the cellular and molecular causes of blood clots. ... MD, a renowned hematologist, past president of ASH, and the ... an individual who has made a recent, outstanding contribution to ...
... known as important sources of energy for all organisms. ... certain types of sugars, known as polysaccharides, may also control ... produce hard structures such as shells and exoskeletons of mollusks, ... of the National Academy of Sciences , Anthony Giuffre, a ...
... is killing you, you may be right, but what you ... even before you were born. In a new report appearing ... Journal , Harvard researchers find that epigenetic disruptions, which ... common at birth. Possibly, these aberrations result from stressors in ...
Cached Biology News:The American Society of Hematology honors Andrew S. Weyrich, Ph.D., with 2013 William Dameshek Prize 2Geoscientists unearth mineral-making secrets potentially useful for new technologies 2Geoscientists unearth mineral-making secrets potentially useful for new technologies 3Fetal stress disrupts the way genes are transmitted 2
(Date:1/15/2014)... January 15, 2014 Cynvenio, a cancer ... through the genomic analysis of tumor cells in the ... a web-based cancer decision support application powered by CollabRx, ... Cynvenio’s ClearID™ genomic test, Therapy Finder will provide breast ...
(Date:1/15/2014)... England , January 15, 2014 A ... win races on the Formula 1 track could help to ... McLaren Applied Technologies (MAT), Stowhealth (a GP surgery based in ... by healthcare provider Simplyhealth. Telemetry technology, which is ...
(Date:1/15/2014)... DTS Language Services, Inc . is ... for Life Science organizations who need document translations. Clients ... of their documents in advance with a selection of nearly ... translations, often a critical factor in clinical and scientific fields, ...
(Date:1/15/2014)... Jan. 15, 2014 TaiGen Biotechnology Company, Limited ("TaiGen") ... with R-Pharm, a leading Russian pharmaceutical company, to develop ... Russian Federation , Turkey ... (CIS). Nemonoxacin is a novel antibiotic for the treatment of ...
Breaking Biology Technology:Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4DTS Improves Efficiency for Life Science Document Translations 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4
... Microscopic robots crafted to maneuver separately without any obvious ... of continuing research led by a Duke University computer ... assembly and control at this fine a resolution with ... Duke professor of computer science and biochemistry. , Each ...
... Pharmaceuticals,Inc. (Nasdaq: AMLN ) today announced that ... diabetes drugs, BYETTA(R) (exenatide) injection and,SYMLIN(R) (pramlintide acetate) ... at the American Diabetes Association,s 68th Annual,Scientific Sessions ... June 6 to,10. The company will also host ...
... June 2 , CALL DATE: Tuesday, June 3, 2008, ... Time, HOST: Dr. Candace ... conduct a telephone conference call and,simultaneous webcast on Tuesday, June 3 ... Research Corporation that,was announced on May 30 and to provide an ...
Cached Biology Technology:Microrobots dance on something smaller than a pin's head 2Microrobots dance on something smaller than a pin's head 3Amylin Pharmaceuticals to Present Promising Data From Diabetes and Obesity Programs at ADA 2008 2Amylin Pharmaceuticals to Present Promising Data From Diabetes and Obesity Programs at ADA 2008 3Amylin Pharmaceuticals to Present Promising Data From Diabetes and Obesity Programs at ADA 2008 4Amylin Pharmaceuticals to Present Promising Data From Diabetes and Obesity Programs at ADA 2008 5Amylin Pharmaceuticals to Present Promising Data From Diabetes and Obesity Programs at ADA 2008 6Amylin Pharmaceuticals to Present Promising Data From Diabetes and Obesity Programs at ADA 2008 7Kendle to Host Conference Call and Webcast to Discuss DecisionLine Acquisition and Provide Update on Second Quarter Progress 2
Assay Diluent, 10 L...
Assay Diluent Trial Pack, 4 x 100 mL...
HRP Monoclonal-Goat Diluent - 5X Concentrate, 25 mL...
SpectroQuest single beam 1.8nm UV/Vis spectrophotometer; stand-alone unit...
Biology Products: