Navigation Links
Scientists uncover evolutionary keys to common birth disorders
Date:1/14/2009

Boston-- The work of Forsyth scientist Peter Jezewski, DDS, Ph.D., has revealed that duplication and diversification of protein regions ('modules') within ancient master control genes is key to the understanding of certain birth disorders. Tracing the history of these changes within the proteins coded by the Msx gene family over the past 600 million years has also provided additional evidence for the ancient origin of the human mouth.

Dr. Jezewski has published an important study examining the Msx family that has ancient roots as a master control gene for patterned embryonic growth. Previous work by Dr. Jezewski, and other groups, identified mutations within the human MSX1 gene in two different birth disorders: either cleft lip and palate or skin derivative disorders ('ectodermal dysplasias') that include tooth and nail malformations. The mutations associated with the more severe clefting disorder are found within unique portions of the MSX protein, thus providing the first molecular explanation for this disease pattern. This work may eventually enable genetically susceptible families with environmental risk factors to prevent these common birth disorders.

Cleft lip and palate is one of the most common birth defects. Both genes and environment contribute to this condition. "If we can learn more about genetic susceptibility of these families, we can start to examine how environmental factors, like maternal smoking, may contribute to their manifestation," says Dr. Jezewski. "This information could lead to recommendations for appropriate behavioral changes within families who are genetically at risk."

Summary of Study

The study, "Domain duplication, divergence, and loss events in vertebrate Msx paralogs reveal phylogenomically informed disease markers," was published in BMC Evolutionary Biology January 14, 2009. This research was led by Dr. Peter Jezewski at The Forsyth Institute, and was conducted with collabor
'/>"/>

Contact: Jennifer Kelly
jkelly@forsyth.org
617-892-8602
Forsyth Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. Invasive plants challenge scientists in face of environmental change
2. Key to future medical breakthroughs is systems biology, say leading European scientists
3. Scripps scientists develop first examples of RNA that replicates itself indefinitely
4. Florida professor creates endowment for insect scientists
5. NYU scientists discover dangerous new method for bacterial toxin transfer
6. Scientists can now differentiate between healthy cells and cancer cells
7. Scientists make strides toward defining genetic signature of Alzheimers disease
8. Johns Hopkins scientists pull proteins tail to curtail cancer
9. Trees wont stop tsunamis, scientists warn
10. UCSB scientists show how certain vegetables combat cancer
11. Hebrew University scientists reveal mechanism that triggers differentiation of embryo cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... puberty is influenced by ,imprinted genes,a subset of genes whose ... This is the first evidence that imprinted genes can control ... study were published today in the journal Nature . ... a marker for the timing of puberty in females. ... girls, is an inherited trait, and is linked to breast ...
(Date:7/24/2014)... (July 24, 2014) Scientists at The New ... one step closer to creating a viable cell ... own cells. , For the first time, ... lines from skin samples of patients with primary ... accelerated protocol to induce these stem cells into ...
(Date:7/24/2014)... species for food or commercial food sale, has been ... decline of many species of primates and other mammals. ... half of the species being consumed are birds, particularly ... only the meat made available for sale but the ... hunters and brought to villages for consumption, we noted ...
Breaking Biology News(10 mins):Could age of first period influence development of diseases in older women? 2NYSCF scientists one step closer to cell therapy for multiple sclerosis patients 2
... around the ancient spruce woodlands of eastern North ... could respond to climate change? Matt Fitzpatrick of ... Appalachian Laboratory, along with researchers from the University ... received a three-year, $670,000 award from the National ...
... Uppsala University, Sweden, instil hope of efficient hydrogen production with ... scepticism based on previous research. The study, which is published ... view on the ability of green algae which is ... producing fuel from renewable energy sources to replace the fossil ...
... Monell Center molecular neurobiologist Peihua Jiang, PhD, is ... Investigators in Gustation, an annual award presented by the ... scientist who is a rising leader in the field ... the understanding of the structure and function of taste ...
Cached Biology News:Scientists look to ancient past to better predict how species may respond climate change 2Surprising findings on hydrogen production in green algae 2Peihua Jiang receives Ajinomoto Award for Young Investigators in Gustation from AChemS 2
(Date:7/24/2014)... Engineering at the University of Delaware, is known ... energy engineering, environmental sustainability and electronics. , His ... with a well-defined, crystalline structure. At the atomic ... that zeolites can separate molecules with size differences ... of a nanometer), making them useful to the ...
(Date:7/24/2014)... (PRWEB) July 24, 2014 Your ... advances in modeling lithium-ion battery storage capacity. , ... from a theoretical model created at Lawrence ... that predicts how carbon components will perform ... storage emphasizes the urgent need for higher-performance batteries. ...
(Date:7/24/2014)... 2014 2014 Deep Research Report ... a professional and in-depth research report on Potassium ... basic information, including its definition, classification, application, ... research covers the international market analysis, including China’s ... covering macroeconomic environment & economic situation analysis, the ...
(Date:7/24/2014)... The first part of the session ... in Human Studies” will cover comprehensive clinical support in ... With increasing R&D costs and declining industry success in ... the knowledge collected in early Phase I/IIa study data ... late stage development. , Next, the presenters will examine ...
Breaking Biology Technology:University of Delaware researcher describes new approach for creating organic zeolites 2Getting More Life out of Lithium-ion Batteries 2Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 2Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 3Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 4Best Practices for Optimizing Dose Escalation in First in Human Studies, New Webinar August 6th Hosted by Xtalks 2
... April 4, 2011 Reportlinker.com announces that ... in its catalogue: Antiviral ... http://www.reportlinker.com/p0203535/Antiviral-Therapeutics---Technologies-markets-and-companies.html ... of antiviral approaches including vaccines, pharmaceuticals and ...
... 2011 Reportlinker.com announces that a new market ... Nanobiotechnologies- applications, markets and companies ... Nanotechnology is the creation and utilization of materials, ... on the nanometer-length scale (a nanometer is one ...
... 4, 2011 GeneLink, Inc. (OTCBB: GNLK, "the ... reported financial results for the fiscal year ended December 31, ... Gross margin increased from $4,906,710 in 2009 to $4,997,367 in ... 2010 as compared to $8,561,455 in 2009; Operating losses ...
Cached Biology Technology:Reportlinker Adds Antiviral Therapeutics - Technologies, Markets and Companies 2Reportlinker Adds Antiviral Therapeutics - Technologies, Markets and Companies 3Reportlinker Adds Antiviral Therapeutics - Technologies, Markets and Companies 4Reportlinker Adds Nanobiotechnologies - Applications, Markets and Companies 2Reportlinker Adds Nanobiotechnologies - Applications, Markets and Companies 3GeneLink Reports 2010 Results 2
Goat polyclonal to Dysadherin ( Abpromise for all tested applications). entrezGeneID: 53827...
Ku80 Antibody Shipping Temperature: HOT Storage Temperature: -20C...
This antibody detects an ~25 kDa band, corresponding to the expected molecular mass of Rab3A, on immunoblots. The antibody specificity is confirmed in peptide inhibition immunoblotting studies....
Rabbit polyclonal to Shigella (HRP) ( Abpromise for all tested applications)....
Biology Products: