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Scientists uncover Achilles heel of chronic inflammatory pain
Date:8/17/2010

Researchers have made a discovery that could lead to a brand new class of drugs to treat chronic pain caused by inflammatory conditions such as arthritis and back pain without numbing the whole body.

The team, funded by the Biotechnology and Biological Sciences Research Council (BBSRC) and working at UCL (University College London), have shown for the first time that genes involved in chronic pain are regulated by molecules inside cells called small RNAs. This mechanism is so different from what has already been discovered about the biology underpinning pain that it could be the Achilles heel of chronic inflammatory pain, which is notoriously difficult to treat. The research appears in The Journal of Neuroscience.

Lead researcher Professor John Wood from UCL said "When a person experiences chronic pain as a result of some sort of inflammation as in arthritis their pain threshold goes down very dramatically. What they can normally do without pain, such as walking or putting on clothes, becomes very painful.

"Chronic inflammatory pain can be treated with pain-killing drugs analgesics but these usually have an impact on the whole body and may also dull our experience of acute pain, which is actually very important as it protects us from injury. Just imagine if you didn't get a sharp pain when you accidentally touch the oven you wouldn't be compelled to take your hand away quickly and could end up with a serious burn.

"What we would really like to be able to do is return the pain thresholds to normal in a person who has chronic inflammatory pain, rather than just numbing the whole body. This would mean that they still get the protection of acute pain. Currently, aspirin-like drugs that can do this have a number of side effects but the present discovery might make it possible to invent a class of drugs that act in a completely novel way."

The researchers studied mice that lack an enzyme called Dicer in some
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Contact: Nancy Mendoza
press.office@bbsrc.ac.uk
44-778-571-0536
Biotechnology and Biological Sciences Research Council
Source:Eurekalert

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