Navigation Links
Scientists trick bacteria with small molecules
Date:10/7/2010

New Haven, Conn.A team of Yale University scientists has engineered the cell wall of the Staphylococcus aureus bacteria, tricking it into incorporating foreign small molecules and embedding them within the cell wall.

The finding, described online in the journal ACS Chemical Biology this week, represents the first time scientists have engineered the cell wall of a pathogenic "Gram-positive" bacteriaorganisms responsible not only for Staph infections but also pneumonia, strep throat and many others. The discovery could pave the way for new methods of combating the bacteria responsible for many of the most infectious diseases.

The team engineered one end of their small molecules to contain a peptide sequence that would be recognized by the bacteria. In Staphylococcus aureus, an enzyme called sortase A is responsible for attaching proteins to the cell wall.

"We sort of tricked the bacteria into incorporating something into its cell wall that it didn't actually make," said David Spiegel, a Yale chemist who led the study. "It's as if the cell thought the molecules were its own proteins rather than recognizing them as something foreign."

The scientists focused specifically on the cell wall because it contains many of the components the cell uses to relate to its environment, Spiegel said. "By being able to manipulate the cell wall, we can in theory perturb the bacteria's ability to interact with human tissues and host cells."

The team used three different small molecules in their experiment including biotin, fluorescein and azide but the technique could be used with other molecules, Spiegel said, as well as with other types of bacteria. Another advantage to the new technique is that the scientists did not have to first genetically modify the bacteria in any way in order for them to incorporate the small molecules, meaning the method should work on naturally occurring bacteria in the human body.

Staph in
'/>"/>

Contact: Suzanne Taylor Muzzin
suzanne.taylormuzzin@yale.edu
203-432-8555
Yale University
Source:Eurekalert

Page: 1 2

Related biology news :

1. DFG awards 4 young scientists 2010 Bernd Rendel Prize
2. Scripps Research scientists develop novel test that identifies river blindness
3. AgriLife Research scientists complete two-year study on short-day onions
4. MBL scientists reveal findings of World Ocean Microbe Census
5. Surprise: Scientists discover that inflammation helps to heal wounds
6. NOAA-sponsored scientists first to map offshore San Andreas Fault and associated ecosystems
7. Scripps Research scientists win $65 million in new grants to reveal form and function of proteins
8. Chromosomal break gives scientists a break in finding new puberty gene
9. Scientists discover a new way our bodies control blood pressure: the P450-EET system
10. Scientists reveal important clues to how bacteria and viruses are identified as enemies
11. Going green: New program provides vital support for plant scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... Nov. 20, 2014   Atmel® Corporation (NASDAQ: ... (MCU) and touch technology solutions, today launched the industry,s ... with the widest V cc range from 1.7V ... and faster I 2 C bus communication speeds, and ... memory making them ideal for consumer, industrial, computer, and ...
(Date:11/18/2014)... , Nov. 17, 2014   ... and EMC collaborate to develop The Partners Data ... , The Partners Data Lake will allow researcher ... improve diagnostics, treatment and the lives of patients ... research and clinical activities across the Partners system, ...
(Date:11/18/2014)... , Nov. 18, 2014   EyeLock ... authentication solutions, and MorphoTrust USA (Safran), ... services, today announced a strategic partnership to offer ... motor vehicle administration (MVA), airport screening and financial ... identity-related solutions, MorphoTrust serves consumers through a nationwide ...
Breaking Biology News(10 mins):Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 2EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 3
... by Yale biologists, of the effects of 1997 El ... the Galpagos Islands, emphasizes the importance of studying populations ... and biological factors make specific populations more vulnerable than ... events provide an ideal system to study the impact ...
... describes hundreds of well-known and respected physicians, scientists, ... or advocated for homeopathic medicine. Eleven U.S. ... Charles Kettering, and C. Everett Koop are among ... benefited from homeopathy. Perhaps most surprisingly is the ...
... CHAMPAIGN, Ill. Using computer simulations, researchers at the University ... driving the molecule back and forth through a nanopore capacitor ... device that would read human genomes quickly and affordably., Being ... (which is the price most insurance companies are willing to ...
Cached Biology News:Global climate change: The impact of El Nio on Galpagos marine iguanas 2The surprising story of Charles Darwin and his homeopathic doctor 2The surprising story of Charles Darwin and his homeopathic doctor 3New technique could dramatically lower costs of DNA sequencing 2
(Date:11/26/2014)... 2014 The North America Thermal ... market for detailed analysis of the growth trends ... reach $616.3 million by 2018, growing at a ... Browse through the TOC of the North America ... idea of the in-depth analysis and industry segmentation ...
(Date:11/26/2014)... , Nov. 26, 2014 The announced ... indicate the company is looking to expand in non-healthcare ... sales.  The healthcare market research firm says that  Siemens ... Kalorama Information,s biennial survey of the IVD market , ... any change in its composition would likely affect IVD ...
(Date:11/26/2014)... The Alliance for Safe Biologic ... European physicians at the "1 ST EuropaBio ... at the Spanish Ministry of Health, Social Services ... the Spanish Bioindustry Association (ASEBIO), included regulators from ... oncology and rheumatology societies, representatives from a hospital ...
(Date:11/26/2014)... November 26, 2014 The ETC ... award-winning technology innovation centers, announced today that applications ... on December 1st. “Do you have a big ... I want to know about it. AccelerateBaltimore helps ... to product in just 13 weeks.” Interested ...
Breaking Biology Technology:The North America Thermal Protective Clothing Market is estimated to grow up to $616.3 million by 2018 - Report by MicroMarket Monitor 2The North America Thermal Protective Clothing Market is estimated to grow up to $616.3 million by 2018 - Report by MicroMarket Monitor 3Kalorama: Sale of Three Siemens Healthcare Units Raises Questions About Firm's IVD Future 2ASBM Presents European Physicians Survey at Spanish Ministry of Health 2AccelerateBaltimore Applications to Close in 6 Days 2AccelerateBaltimore Applications to Close in 6 Days 3
... Centers,of America, Inc. (Navitas), the market leader in ... to announce the,appointment of Dean H. Gesme, Jr., ... to currently providing care as a medical oncologist ... as the Past-Chair of the,National Coalition for Cancer ...
... Oct. 17 Monsanto Company (NYSE:,MON) today announced ... president and chief executive officer, and Robb Fraley, ... stock trading,plans in accordance with Rule 10b5-1 of ... plans, the Monsanto executives have directed brokers in ...
... Calif. and OSAKA, Japan, Oct. 17 Affymax,Inc. ... Limited (TSE: 4502),today announced that they have been ... Licensing Executives Society of the U.S. and Canada ... commercialize,Affymax,s lead product candidate, Hematide(TM), for the treatment ...
Cached Biology Technology:Navitas Names Dr. Dean Gesme as Medical Director 2Affymax(R) and Takeda Recognized for Innovative Global Agreement to Develop and Commercialize Hematide(TM) for Anemia 2Affymax(R) and Takeda Recognized for Innovative Global Agreement to Develop and Commercialize Hematide(TM) for Anemia 3
... Invitrogens EvoQuest Services are ... prevail in the current competitive ... proprietary techniques to express, purify, ... your needs: Structure/Function Studies, Activity ...
... Standard Tray (3 per pack), 1. ... and blot processing.Automated staining of Coomassie ... and nucleic acid analysis.Prepares blots for ... detection.Programmable control of protocol, solution, volume, ...
... High quality kits and reagents ... give consistent and reliable 2-D ... up samples from contaminants.Efficiently dialyze ... protein for first-dimension isoelectric focusing.Reagents ...
IMAGEQUANT 300 WKSTN, 1 EA. Category: ImageQuant CCD Imagers....
Biology Products: