Navigation Links
Scientists track impact of DNA damage in the developing brain
Date:7/27/2009

Switching off a key DNA repair system in the developing nervous system is linked to smaller brain size as well as problems in brain structures vital to movement, memory and emotion, according to new research led by St. Jude Children's Research Hospital scientists.

The work, published in the August issue of the journal Nature Neuroscience, also provides the first evidence that cells known as cerebellar interneurons are targeted for DNA damage and are a likely source of neurological problems in humans. The cerebellum coordinates movement and balance. The cerebellar interneurons fine tune motor control.

"These data will be important for understanding the role the DNA damage response plays in preventing neurological disease," the investigators wrote.

The study also marks the first time researchers have switched off a pathway for repairing damaged single DNA strands in an organ system, in this case the mouse brain and nervous system. While the results suggest certain brain cells are particularly vulnerable, investigators report that with time DNA damage accumulates throughout the nervous system. Some mice in the study eventually develop seizures and difficulty walking.

Peter J. McKinnon, Ph.D., a member of St. Jude Genetics and Tumor Cell Biology, said the work provides a new model for understanding how single-strand DNA damage affects the nervous system and offers a new focus for tracking the origins of neurological disease.

The research also reflects growing scientific interest in damage to single strands of DNA. "A variety of human disease syndromes result from problems in the DNA-repair system," explained McKinnon, the paper's senior author.

DNA is the double-stranded molecule found in nearly every cell. In organisms both simple and complex, it serves as the biochemical blueprint for assembling and sustaining life. Diseases like cancer have long been associated with unrepaired damage to both strands of
'/>"/>

Contact: Summer Freeman
summer.freeman@stjude.org
901-595-3061
St. Jude Children's Research Hospital
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scientists closer to making implantable bone material, thanks to new research
2. What scientists know about jewel beetle shimmer
3. Scientists discover gene mutation responsible for hereditary neuroendocrine tumor
4. Scientists link immune systems natural killer cells to infant liver disease
5. Scientists report first remote, underwater detection of harmful algae, toxins
6. Childrens Hospital of Pittsburgh of UPMC scientists identify enzyme important in aging
7. 2 Fred Hutchinson Cancer Research Center scientists receive Presidential Early Career Award
8. Forsyth scientists suggest linkages between obesity and oral bacterial infection
9. Scientists closer to developing salt-tolerant crops
10. Scientists track chemical changes in cells as they endure extreme conditions
11. Scientists are learning more about big birds from feathers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/15/2014)... have succeeded in visualizing the movement within plants ... resistance to drought. The achievement will allow researchers ... hormone helps plants respond to drought and other ... the atmosphere,s carbon dioxide, or CO2, concentration., A ... 15 issue of the scientific journal eLife ...
(Date:4/15/2014)... who study the deadliest infectious diseases recognized the contributions ... at the University of Texas Medical Branch, with a ... on Filoviruses. The filoviruses include Ebola and Marburg viruses ... people infected. The current outbreak of Ebola virus raging ... so far. , "This award represents the culmination ...
(Date:4/15/2014)... dental researchers have found a less invasive way ... mouth to study how the mouth,s natural defenses ... some specialized immune cells (white blood cells known ... in the mouthor reject foreign tissues, such as ... about treating and preventing such health issues as ...
Breaking Biology News(10 mins):Biologists develop nanosensors to visualize movements and distribution of plant hormone 2International research group recognizes UTMB experts 2International research group recognizes UTMB experts 3New method isolates immune cells for researchers to study how they ward off oral diseases 2
... world and ensuring safe water supplies would do more to ... possible measure, according to an analysis released today by the ... sanitation reduces poverty in three ways. ... , Significant savings are achieved in the public health ...
... International Union for the Conservation of Nature,s (IUCN) ... urging nations to protect the leatherback sea turtle ... identifying and creating marine protected areas along the ... scientists, government officials and environmental organizations from over ...
... from the California Institute of Technology (Caltech) have created ... biological computer--that is capable of taking in and responding ... a time. In the future, such devices could ... used as sensors to sniff out tumor cells or ...
Cached Biology News:Providing toilets, safe water is top route to reducing world poverty: UN University 2Providing toilets, safe water is top route to reducing world poverty: UN University 3Providing toilets, safe water is top route to reducing world poverty: UN University 4Providing toilets, safe water is top route to reducing world poverty: UN University 5Scientists call for protected 'swimways' for the endangered leatherback sea turtle 2Scientists call for protected 'swimways' for the endangered leatherback sea turtle 3Caltech engineers build firast-ever multi-input 'plug-and-play' synthetic RNA device 2
(Date:1/15/2014)... January 15, 2014 This webinar ... on nonclinical and clinical safety assessment in biosimilars. ... guide a path for biosimilar drug development, however ... of biosimilarity with regards to quality, safety and ... of biosimilar drug development and registration, development strategies ...
(Date:1/15/2014)... NC (PRWEB) January 15, 2014 ... an enhancement to its Online Web Portal for Life ... now have the ability to specify the subject matter ... nearly 50 life science sub-domains. This will help reduce ... and scientific fields, and decrease the likelihood of error. ...
(Date:1/14/2014)... Doylestown, PA (PRWEB) January 14, 2014 ... – 11 p.m. , Location: Warrington Country Club, 1360 ... Hepatitis B Foundation, the only national nonprofit organization solely ... improving the quality of life for those affected worldwide, ... 11 at Warrington Country Club in Warrington, Pa. ...
(Date:1/14/2014)... York, NY (PRWEB) January 14, 2014 ... initiated coverage of Alliqua, Inc. (OTCQB: ALQA). Alliqua ... and marketing proprietary products to serve the wound ... , In late 2012, Alliqua was restructured ... launched the company’s new strategy to become a ...
Breaking Biology Technology:Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2DTS Improves Efficiency for Life Science Document Translations 2Hepatitis B Foundation to Host Annual Crystal Ball Gala 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
... PALO ALTO, Calif., Aug. 21 Telik, Inc.,(Nasdaq: ... compounds of its Aurora kinase,and VEGFR dual inhibitor ... a critical signaling enzyme whose function is required ... receptor,(VEGFR) plays a key role in tumor blood ...
... 21 Omaxe Infrastructure &,Construction Private Ltd(OICPL), a wholly ... Intent for the construction of Allopathic Medical,College and Associated ... The construction value of the project is Rs250 crores,approx., ... 62 acres with total built up area,of 15.66 lac ...
... /Xinhua-PRNewswire-FirstCall/ --,China-Biotics, Inc. (OTC Bulletin Board: ... firm specializing in the manufacture,research, development, ... announced it signed a one-year contract ... Pharmaceutical") to supply probiotics for,Square Pharmaceutical,s ...
Cached Biology Technology:Telik's Aurora Kinase-VEGFR Dual Inhibitor Program Meets a Preclinical Development Milestone 2Omaxe Infrastructure & Construction Private Ltd Receives LoI for Construction of Allopathic Medical College and Associated Hospital at Saharanpur, UP With Construction Value of Approx 250 Crores 2China-Biotics, Inc. Continues to Broaden Bulk Additives Client Base 2China-Biotics, Inc. Continues to Broaden Bulk Additives Client Base 3
... The ApopTag Red In Situ Apoptosis ... by the indirect TUNEL method, utilizing ... fluorochrome. The kit provides indirect immunofluorescence ... analyzed using either fluorescence microscopy or ...
The sample holders for gels are used to hold gels in place in the multi-sample tray I, which is used with Molecular Imager FX imaging systems....
... gel cell is a stand-alone apparatus that ... applications. The upper buffer chamber can accommodate ... long for isoelectric focusing (IEF) applications. The ... cooling core, lower buffer chamber, lid with ...
... The ApopTag Fluorescein In Situ ... in situ by the indirect TUNEL ... is conjugated to a Fluorescein reporter ... for 40 samples. Results are analyzed ...
Biology Products: