Navigation Links
Scientists tap into spinal response from gastric reflux
Date:10/1/2013

University of Adelaide researchers have made advances in the understanding of one of the world's most common medical conditions, gastric reflux, and how patients experience pain from it.

Gastric reflux affects as many as one in five people in Western countries and is on the increase in Asia. Diet and lifestyle, as well as genetic and hormonal issues, are commonly considered to be major causes of gastric reflux.

In laboratory studies, researchers have identified the nerve pathways in the spinal cord that transmit pain signals associated with gastric reflux to the brain.

"This is the first time anyone has shown the pain pathways in the spinal cord that receive direct input from acid-sensitive nerve endings in the esophagus," says Dr Andrea Harrington, an Australian Research Council (ARC) DECRA Research Fellow in the University's Nerve-Gut Laboratory.

"This is important because we know that the esophageal nerves undergo changes in gastric reflux patients that make them overly sensitive to acid. There is also evidence to suggest that the whole circuitry becomes abnormally sensitive in these patients, resulting in ongoing pain responses in the absence of actual acid reflux. Our research will enable us to identify such mechanisms," she says.

Dr Harrington says it's important to better understand how we detect and perceive pain from gastric reflux.

"Being able to know exactly how pain pathways connect to the brain will give us new insights, which in the years ahead could lead to improved treatment," she says.

Dr Harrington says most current treatments focus on reducing the amount of acid in the stomach.

"However, we think it's a much more complex issue than that. There might come a time when treatments are able to both address the amount of acid in the stomach while correcting the sensitivity of nerve endings. This would go a long way to providing more balanced relief to suffers of gastric reflux."

The next step in this research is to find out how the pain pathways are changed in reflux sufferers.


'/>"/>

Contact: Dr. Andrea Harrington
andrea.harrington@adelaide.edu.au
61-882-222-602
University of Adelaide
Source:Eurekalert

Related biology news :

1. BGI scientists win BioMed Central Open Data Award
2. When cells eat their own power plants; Pitt scientists solve mystery of cellular process
3. UCI achieves rare trifecta: 3 scientists receive New Innovator Awards
4. Beyond the little blue pill: scientists develop compound that may treat priapism
5. 3D mapping is a Pisa cake for Aussie scientists
6. Scientists discover environmental enrichment for TBI patients may counter shrinkage in the brain
7. USC scientists ID protein that regulates cellular trafficking, potential for anti-cancer therapy
8. Scientists closer to universal flu vaccine after pandemic natural experiment
9. Online citizen scientists: Classify plankton images
10. Scientists creating new diagnostic and bioinformatics tools for psychotic disorders
11. Scientists discover cosmic factory for making building blocks of life
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2016)... , March 31, 2016   ... ("LegacyXChange" or the "Company") LegacyXChange is excited ... of its soon to be launched online site for ... https://www.youtube.com/channel/UCyTLBzmZogV1y2D6bDkBX5g ) will also provide potential shareholders a ... DNA technology to an industry that is notorious for ...
(Date:3/29/2016)... 29, 2016 LegacyXChange, Inc. (OTC: ... and SelectaDNA/CSI Protect are pleased to announce our successful ... a variety of writing instruments, ensuring athletes signatures against ... collectibles from athletes on LegacyXChange will be assured of ... DNA. Bill Bollander , CEO states, ...
(Date:3/22/2016)... PUNE, India , March 22, 2016 ... new market research report "Electronic Sensors Market for ... Fingerprint, Proximity, & Others), Application (Communication & ... and Geography - Global Forecast to 2022", ... consumer industry is expected to reach USD ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... 23, 2016   Boston Biomedical , an ... designed to target cancer stemness pathways, announced that ... Orphan Drug Designation from the U.S. Food and ... cancer, including gastroesophageal junction (GEJ) cancer. Napabucasin is ... inhibit cancer stemness pathways by targeting STAT3, and ...
(Date:6/23/2016)... ... 2016 , ... Charm Sciences, Inc. is pleased to announce ... Research Institute approval 061601. , “This is another AOAC-RI approval of the Peel ... President of Regulatory and Industrial Affairs. “The Peel Plate methods perform comparably to ...
(Date:6/23/2016)... ... June 23, 2016 , ... Supplyframe, the Industry Network for ... Design Lab . Located in Pasadena, Calif., the Design Lab’s mission is to ... are designed, built and brought to market. , The Design Lab is Supplyframe’s ...
(Date:6/23/2016)... , June 23, 2016  Blueprint Bio, a company ... to the medical community, has closed its Series A ... Nunez . "We have received a commitment ... capital we need to meet our current goals," stated ... us the runway to complete validation on the current ...
Breaking Biology Technology: