Navigation Links
Scientists tap into spinal response from gastric reflux
Date:10/1/2013

University of Adelaide researchers have made advances in the understanding of one of the world's most common medical conditions, gastric reflux, and how patients experience pain from it.

Gastric reflux affects as many as one in five people in Western countries and is on the increase in Asia. Diet and lifestyle, as well as genetic and hormonal issues, are commonly considered to be major causes of gastric reflux.

In laboratory studies, researchers have identified the nerve pathways in the spinal cord that transmit pain signals associated with gastric reflux to the brain.

"This is the first time anyone has shown the pain pathways in the spinal cord that receive direct input from acid-sensitive nerve endings in the esophagus," says Dr Andrea Harrington, an Australian Research Council (ARC) DECRA Research Fellow in the University's Nerve-Gut Laboratory.

"This is important because we know that the esophageal nerves undergo changes in gastric reflux patients that make them overly sensitive to acid. There is also evidence to suggest that the whole circuitry becomes abnormally sensitive in these patients, resulting in ongoing pain responses in the absence of actual acid reflux. Our research will enable us to identify such mechanisms," she says.

Dr Harrington says it's important to better understand how we detect and perceive pain from gastric reflux.

"Being able to know exactly how pain pathways connect to the brain will give us new insights, which in the years ahead could lead to improved treatment," she says.

Dr Harrington says most current treatments focus on reducing the amount of acid in the stomach.

"However, we think it's a much more complex issue than that. There might come a time when treatments are able to both address the amount of acid in the stomach while correcting the sensitivity of nerve endings. This would go a long way to providing more balanced relief to suffers of gastric reflux."

The next step in this research is to find out how the pain pathways are changed in reflux sufferers.


'/>"/>

Contact: Dr. Andrea Harrington
andrea.harrington@adelaide.edu.au
61-882-222-602
University of Adelaide
Source:Eurekalert

Related biology news :

1. BGI scientists win BioMed Central Open Data Award
2. When cells eat their own power plants; Pitt scientists solve mystery of cellular process
3. UCI achieves rare trifecta: 3 scientists receive New Innovator Awards
4. Beyond the little blue pill: scientists develop compound that may treat priapism
5. 3D mapping is a Pisa cake for Aussie scientists
6. Scientists discover environmental enrichment for TBI patients may counter shrinkage in the brain
7. USC scientists ID protein that regulates cellular trafficking, potential for anti-cancer therapy
8. Scientists closer to universal flu vaccine after pandemic natural experiment
9. Online citizen scientists: Classify plankton images
10. Scientists creating new diagnostic and bioinformatics tools for psychotic disorders
11. Scientists discover cosmic factory for making building blocks of life
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2017)... , April 18, 2017  Socionext Inc., a global expert in ... media edge server, the M820, which features the company,s hybrid codec ... provided by Tera Probe, Inc., will be showcased during the upcoming ... NAB show at the Las Vegas Convention ... Click ...
(Date:4/11/2017)... April 11, 2017 Crossmatch®, a globally-recognized ... solutions, today announced that it has been awarded ... Projects Activity (IARPA) to develop next-generation Presentation Attack ... "Innovation has been a driving force within ... will allow us to innovate and develop new ...
(Date:4/6/2017)... , April 6, 2017 Forecasts ... ANPR, Document Readers, by End-Use (Transportation & Logistics, Government ... Oil, Gas & Fossil Generation Facility, Nuclear Power), Industrial, ... Other) Are you looking for a definitive ... ...
Breaking Biology News(10 mins):
(Date:7/17/2017)... ... July 17, 2017 , ... ... long-standing innovation strategy. A website (openinnovation.pioneer.com) dedicated to connecting third-party innovators ... – trait discovery, plant breeding, enabling technologies, biologicals and digital solutions. , “DuPont ...
(Date:7/14/2017)... (PRWEB) , ... July 14, 2017 , ... ... conscious EMS company . Sonic Manufacturing Technologies has installed a solar system on ... in a three-year period,” the President of Sonic, Kenneth Raab stated. The company’s ...
(Date:7/13/2017)... ... 2017 , ... Thousands of pilots from across the country will visit the ... Pilots come to Muncie to compete in various categories of model flying competition. Each ... in world championships. , RC Pylon (July 14-21): One of the most fun competitions ...
(Date:7/13/2017)... ... July 13, 2017 , ... Frederick’s first and ... robust growth in the past year after an intensive restructuring. Under the leadership ... Programs and expanded its board of directors to revitalize the organization. As a ...
Breaking Biology Technology: