Navigation Links
Scientists take early steps toward mapping epigenetic variability

PROVIDENCE, R.I. [Brown University] Brown University and other scientists have taken the first steps toward mapping epigenetic variability in cells and tissues. Mapping the human epigenome, similar to the human genome project in the 1990s, could someday allow for quicker and more precise disease diagnoses and more targeted treatments of many chronic ailments.

Details are published online in the latest edition of PLoS Genetics.

Epigenetics, a relatively new endeavor in science, refers to the control of the patterns of gene expression in cells, which gives rise to the necessary differences responsible for creating the complex and interacting tissues in the body.

Scientists globally have begun working on a Human Epigenome Project in a bid to compile detailed data documenting, within a person, the epigenetic changes in different types of cells and tissues, something that will complement the already-completed Human Genome Project.

The Brown-led effort completes a far-reaching study of more than 200 human tissue samples in a bid to map variations in epigenomic structure. Collaborators from the Harvard School of Public Health and Harvard Medical School, the University of CaliforniaSan Francisco, University of MinnesotaMinneapolis, Dartmouth Medical School, Women & Infants Hospital in Providence, and Brigham and Women's Hospital in Boston took part in the effort.

Their findings: Human cells display wide epigenetic variation that appears related to aging and smoking, which may increase susceptibility to several diseases such as cancer. While the scientists emphasize that more research is necessary, they say that taking a step to map epigenetic variability will help bring them closer to discovering important epigenetic differences in people, which in turn could help better diagnose disease and create more targeted treatments. Alterations in epigenetic marks in cells have been linked to many diseases and conditions in humans, including cancer.

"Scientists have already found out it is critical to look at genetic variation to diagnose disease," said Brock Christensen, a postdoctoral research associate at Brown University's Department of Pathology and Laboratory Medicine. "What we are trying to do is complement that by looking at what is normal and how much variation in epigenetics exists."

Christensen said that more tissue samples and data are needed to allow for a thorough mapping of epigenetic variability in cells.

That endeavor is important, as scientists need to gauge normal human epigenomic variability as part of the broader mapping process, said Karl Kelsey, corresponding author and a Brown professor of community health and pathology and laboratory medicine.

"The real importance of the work has to do with beginning to define what is normal in different tissues," Kelsey said. "And then you dig deeper to see what is the same and different about different people."

The study involved analysis of 217 nonpathologic human tissue sampless including blood, lung, head and neck, and brain tissue.


Contact: Mark Hollmer
Brown University

Related biology news :

1. UOG scientists successfully compete for research grants
2. Canadian scientists identify gene that makes water striders glide across water
3. Scientists conduct shark survey off US East Coast
4. Scientists demonstrate importance of niche differences in biodiversity
5. Scientists devise efficient way of learning about complex corn traits
6. NIH stimulus funding supports Emory biomedical scientists
7. Scientists find universal rules for food-web stability
8. Scientists open doors to diagnosis of emphysema
9. Scientists decoding genomic sequences of H1N1 using isolates from outbreak in Argentina
10. Scientists uncork a potential secret of red wines health benefits
11. Scientists discover Amazon river is 11 million years old
Post Your Comments:
Related Image:
Scientists take early steps toward mapping epigenetic variability
(Date:10/29/2015)... ARBOR, Mich. , Oct. 29, 2015 /PRNewswire/ ... Eurofins Genomics for U.S. distribution of its DNA ... DNA-seq kit and Rubicon,s new ThruPLEX Plasma-seq kit. ... to enable the preparation of NGS libraries for ... plasma for diagnostic and prognostic applications in cancer ...
(Date:10/29/2015)... October 29, 2015 NXTD ... company focused on the growing mobile commerce market ... that StackCommerce, a leading marketplace to discover and ... Wocket® smart wallet on StackSocial for this holiday ... or the "Company"), a biometric authentication company focused ...
(Date:10/27/2015)... 2015 In the present market scenario, security ... various industry verticals such as banking, healthcare, defense, electronic ... demand for secure & simplified access control and growing ... hacking of bank accounts, misuse of users, , and ... PC,s, laptops, and smartphones are expected to provide potential ...
Breaking Biology News(10 mins):
(Date:11/23/2015)... -- Women with a certain type of lung nodule visible ... of lung cancer than men with similar nodules, according to ... meeting of the Radiological Society of North America ... --> Lung nodules are small masses of tissue in ... on their appearance on CT. Solid nodules are dense, and ...
(Date:11/23/2015)... ... November 23, 2015 , ... ... the development of its Nexera UC Unified Chromatography system. The award from R&D ... significant new products of the year in the analytical and testing category. R&D ...
(Date:11/23/2015)... PISCATAWAY, New Jersey , November ... Data Centre (CCDC) announces the launch of ... (CSD) and the CSD-System, now complemented by three ... to support the discovery of new molecules, CSD-Materials ... the complete set of the CCDC,s applications incorporating ...
(Date:11/23/2015)... WASHINGTON , Nov. 23, 2015 ... research firm to exclusively serve the ... of its global strategic report, "Mesenchymal ... Published November 2015, it presents 250 ... mesenchymal stem cell (MSC) industry. ...
Breaking Biology Technology: