Navigation Links
Scientists take early steps toward mapping epigenetic variability
Date:8/14/2009

PROVIDENCE, R.I. [Brown University] Brown University and other scientists have taken the first steps toward mapping epigenetic variability in cells and tissues. Mapping the human epigenome, similar to the human genome project in the 1990s, could someday allow for quicker and more precise disease diagnoses and more targeted treatments of many chronic ailments.

Details are published online in the latest edition of PLoS Genetics.

Epigenetics, a relatively new endeavor in science, refers to the control of the patterns of gene expression in cells, which gives rise to the necessary differences responsible for creating the complex and interacting tissues in the body.

Scientists globally have begun working on a Human Epigenome Project in a bid to compile detailed data documenting, within a person, the epigenetic changes in different types of cells and tissues, something that will complement the already-completed Human Genome Project.

The Brown-led effort completes a far-reaching study of more than 200 human tissue samples in a bid to map variations in epigenomic structure. Collaborators from the Harvard School of Public Health and Harvard Medical School, the University of CaliforniaSan Francisco, University of MinnesotaMinneapolis, Dartmouth Medical School, Women & Infants Hospital in Providence, and Brigham and Women's Hospital in Boston took part in the effort.

Their findings: Human cells display wide epigenetic variation that appears related to aging and smoking, which may increase susceptibility to several diseases such as cancer. While the scientists emphasize that more research is necessary, they say that taking a step to map epigenetic variability will help bring them closer to discovering important epigenetic differences in people, which in turn could help better diagnose disease and create more targeted treatments. Alterations in epigenetic marks in cells have been linked to many diseases and conditions in humans, including cancer.

"Scientists have already found out it is critical to look at genetic variation to diagnose disease," said Brock Christensen, a postdoctoral research associate at Brown University's Department of Pathology and Laboratory Medicine. "What we are trying to do is complement that by looking at what is normal and how much variation in epigenetics exists."

Christensen said that more tissue samples and data are needed to allow for a thorough mapping of epigenetic variability in cells.

That endeavor is important, as scientists need to gauge normal human epigenomic variability as part of the broader mapping process, said Karl Kelsey, corresponding author and a Brown professor of community health and pathology and laboratory medicine.

"The real importance of the work has to do with beginning to define what is normal in different tissues," Kelsey said. "And then you dig deeper to see what is the same and different about different people."

The study involved analysis of 217 nonpathologic human tissue sampless including blood, lung, head and neck, and brain tissue.


'/>"/>

Contact: Mark Hollmer
Mark_Hollmer@brown.edu
401-863-1862
Brown University
Source:Eurekalert  

Related biology news :

1. UOG scientists successfully compete for research grants
2. Canadian scientists identify gene that makes water striders glide across water
3. Scientists conduct shark survey off US East Coast
4. Scientists demonstrate importance of niche differences in biodiversity
5. Scientists devise efficient way of learning about complex corn traits
6. NIH stimulus funding supports Emory biomedical scientists
7. Scientists find universal rules for food-web stability
8. Scientists open doors to diagnosis of emphysema
9. Scientists decoding genomic sequences of H1N1 using isolates from outbreak in Argentina
10. Scientists uncork a potential secret of red wines health benefits
11. Scientists discover Amazon river is 11 million years old
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists take early steps toward mapping epigenetic variability
(Date:4/28/2016)... 28, 2016 First quarter 2016:   ... compared with the first quarter of 2015 The gross ... M (loss: 18.8) and the operating margin was 40% (-13) ... Cash flow from operations was SEK 249.9 M (21.2) , ... is unchanged, SEK 7,000-8,500 M. The operating margin for ...
(Date:4/15/2016)... 2016 Research and Markets has ... Market 2016-2020,"  report to their offering.  , ... ,The global gait biometrics market is expected to ... period 2016-2020. Gait analysis generates multiple ... used to compute factors that are not or ...
(Date:3/29/2016)... 29, 2016 LegacyXChange, Inc. (OTC: ... and SelectaDNA/CSI Protect are pleased to announce our successful ... a variety of writing instruments, ensuring athletes signatures against ... collectibles from athletes on LegacyXChange will be assured of ... DNA. Bill Bollander , CEO states, ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... 23, 2016 , ... UAS LifeSciences, one of the leading ... UP4™ Probiotics, into Target stores nationwide. The company, which has been manufacturing high ... its list of well-respected retailers. This list includes such fine stores as Whole ...
(Date:6/23/2016)... June 23, 2016 /PRNewswire/ - FACIT has announced ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" ... commercialization of a portfolio of first-in-class WDR5 inhibitors ... such as WDR5 represent an exciting class of ... precision medicine for cancer patients. Substantial advances have ...
(Date:6/23/2016)... 23, 2016 Houston Methodist Willowbrook Hospital ... Sports Association to serve as their official health ... Methodist Willowbrook will provide sponsorship support, athletic training ... association coaches, volunteers, athletes and families. ... Sports Association and to bring Houston Methodist quality ...
(Date:6/23/2016)... June 23, 2016  The Prostate Cancer Foundation (PCF) is pleased ... and faster cures for prostate cancer. Members of the Class of 2016 were ... Read More About the Class of 2016 PCF Young ... ... ...
Breaking Biology Technology: