Navigation Links
Scientists synthesize long-sought-after anticancer agent
Date:1/31/2011

rapy drugs. "Ovarian cancer has a high rate of recurrence, and after using chemotherapy to fight the tumor the first time, you're left with resistant tumor cells that tend to keep coming back," Mor explained. "If you can kill the stem cells before they have the chance to form a tumor, the patient will have a much better chance of survival and there aren't many potential therapies out there that target cancer stem cells right now."

Herzon's team, which managed to synthesize the molecule in just 11 steps starting from basic chemical building blocks, has been working on the problem since 2008 and spent more than a year on just one step of the process involving the creation of a carbon-carbon bond. It was an achievement that many researchers deemed impossible, but while others tried to work around having to create that bond by using other techniques, the team's persistence paid off.

"A lot of blood, sweat and tears went into creating that bond," Herzon said. "After that, the rest of the process was relatively easy."

Next, the team will continue to analyze the compound to better understand what's happening to the stem cells at the molecular level. The team hopes to begin testing the compounds in animals shortly.

"This is a great example of the synergy between basic chemistry and the applied sciences," Herzon said. "Our original goal of synthesizing this natural product has led us into entirely new directions that could have broad impacts in human medicine."


'/>"/>

Contact: Suzanne Taylor Muzzin
suzanne.taylormuzzin@yale.edu
203-432-8555
Yale University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scientists climb Mt. Everest to explain how hearts adapt and recover from low oxygen
2. Scripps Research scientists convert skin cells to beating heart cells
3. Scripps Research scientists reveal key mechanism governing nicotine addiction
4. Scientists determine what makes an orangutan an orangutan
5. Scientists link protein to the insulation of the nervous systems wiring
6. Scientists grow human liver tissue to be used for transplantation
7. Scientists reveal complete structure of HIVs outer shell
8. Scientists: Big city life may alter green attitudes
9. Scientists find the master switch for key immune cells in inflammatory diseases
10. MU scientists find new farming method to reduce greenhouse gases, increase farm yields
11. 7 CAMH scientists win Young Investigator awards focused on breakthrough research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... cells offer much promise for treating damaged organs and ... is poor, limiting their effectiveness. New methods are being ... their therapeutic function after transplantation, as described in a ... peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The ... Access website . , In the ...
(Date:7/22/2014)... July 22, 2014 BGI Tech Solutions Co., ... world,s largest genomics organization, announced today the global ... service based on Complete Genomics, industry-leading platform. This ... SNP validation, and is available at reduced prices ... highly regarded in the industry for providing proprietary ...
(Date:7/22/2014)... emerging as a world-famous vacation spot with natural tourism resources, ... island. The Korea Institute of Geoscience and Mineral Resources (KIGAM) ... recent volcanic eruption was evident 5,000 years ago. That is ... lava spewed out of a volcano 5,000 years ago in ... one the whole peninsula. , The research team led by ...
Breaking Biology News(10 mins):BGI Tech launches human whole exome sequencing service on complete genomics' advanced platform 2Jeju Island is a live volcano 2
... some amphibians possess a unique sensory capability in the ... "touch" objects in their surroundings without direct physical contact ... Hermmen and his team in the physics department of ... for this sensory system. What they discover might one ...
... A method to detect contaminants in municipal water supplies ... Laboratory researchers whose findings are published on line in ... demonstrates that the technology that uses algae as sentinels ... Miguel Rodriguez Jr. and Elias Greenbaum of the Department ...
... to the "hardwired for news" theory, people devote more ... test the theory, University of Missouri researchers examined the ... researchers found that news about local health threats increased ... distant, or non-local, health threats. "Although journalists ...
Cached Biology News:Mathematical keys to a sixth sense -- the lateral-line system 2Mathematical keys to a sixth sense -- the lateral-line system 3Mathematical keys to a sixth sense -- the lateral-line system 4ORNL scientists hone technique to safeguard water supplies 2Online news garners more attention from readers if it's negative and localized, MU study finds 2
(Date:7/22/2014)... July 22, 2014 Automated cell culture ... maintenance of cell culture. They allow production of optimum ... of researchers in drug discovery and industries and biopharmaceutical ... mAb production, iPSC research, cryobanking, cell-based assays, and cellular ... risk. , Analysts forecast the Global Cell Culture ...
(Date:7/22/2014)... 22, 2014 Two new members were ... Directors at its annual Shareholders Meeting on June 13: ... of The PFM Group, and Stephen T. Zarrilli, President ... announced the election of Michael A. DiPiano, Managing General ... and Richard P. Jaffe, Esq., of Duane Morris LLP, ...
(Date:7/22/2014)... CAMBRIDGE, Massachusetts og SHENZHEN ... BGI Tech Solutions Co., LTD, (BGI Tech), et ... globale lancering af en ny human whole exome-sekvenseringstjeneste ... Complete Genomics, højt anset i branchen for ... og højfølsom registrering af alle typer varianter, blev ...
(Date:7/22/2014)... SHENZHEN, China , July 22, 2014 /PRNewswire/ ... a subsidiary of BGI, the world,s largest genomics ... new human whole exome sequencing service based on ... includes in-depth bioinformatics analysis and SNP validation, and ... 2014. Complete Genomics, highly regarded ...
Breaking Biology Technology:Global Cell Culture Market to Grow at 10.27% CAGR by 2018 Forecasts a New Research Report ReportsnReports.com 2Global Cell Culture Market to Grow at 10.27% CAGR by 2018 Forecasts a New Research Report ReportsnReports.com 3Global Cell Culture Market to Grow at 10.27% CAGR by 2018 Forecasts a New Research Report ReportsnReports.com 4Two New Members Elected to University City Science Center Board of Directors 2Two New Members Elected to University City Science Center Board of Directors 3BGI Tech lancerer Human Whole Exome-sekvenseringstjeneste på Complete Genomics avancerede platform 2BGI Tech Launches Human Whole Exome Sequencing Service on Complete Genomics' Advanced Platform 2BGI Tech Launches Human Whole Exome Sequencing Service on Complete Genomics' Advanced Platform 3
... receive funding for technology development projects from the ... Grant program. , ,The TAG program provides grants ... companies to offset the cost of professional services. ... Automated Notification Systems, Inc. , Eau Claire; Micrablate, ...
... the balkanization of information technology in healthcare will take ... Digital Healthcare Conference 2006 . And vendors aren't necessarily ... customers. , ,Providers are facing that common IT problem: ... of vendors and systems with challenges agreeing to standards, ...
... a gathering of health professionals attending the eHealth Summit ... first state to have a fully integrated electronic medical ... barriers. , ,Speaking before a group of healthcare executives, ... state's eHealth Initiative, Doyle said those barriers include organizational ...
Cached Biology Technology:Being proactive with vendors helps healthcare improve IT 2Doyle asks health professionals to overcome barriers 2Doyle asks health professionals to overcome barriers 3
MOUSE ANTI HUMAN MBP (67-74) Immunogen: Human myelin basic protein...
... is designed to purify double-stranded DNA (dsDNA) generated ... PCR. The process is simple and fast. DNA ... can be efficiently purified and concentrated. The DNAclear ... bound to the Microfilter Cartridge in the presence ...
Normal donkey serum collected from healthy normal donkeys....
Whole blood is collected from canines (any breed, either sex), refrigerated within 6 hours, processed within 24 hours and frozen at -20C....
Biology Products: