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Scientists successfully use human induced pluripotent stem cells to treat Parkinson's in rodents
Date:8/16/2010

SCs have been demonstrated to survive and correct behavioral deficits in PD in the past. "Both our functional studies and genomic analyses suggest that overall iPSCs are largely similar to hESCs," said Zeng.

The research also addresses the current lack of a robust system for the efficient production of functional dopamine-producing neurons from human iPSCs, Zeng said. The protocol used to differentiate the iPSCs was similar to one developed by Zeng and colleagues for hESCs. "Our approach will facilitate the adoption of protocols to good manufacturing practice standards, which is a pre-requisite if we are to move iPSC's into clinical trials in humans," said Zeng.

"The studies are very encouraging for potential cell therapies for Parkinson's disease," said Alan Trounson, Ph.D., the President of the California Institute for Regenerative Medicine. "The researchers showed they could produce quantities of dopaminergic neurons necessary to improve the behavior of a rodent model of PD. We look forward to further work that could bring closer a new treatment for such a debilitating disease," Trounson said.


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Contact: Kris Rebillot
krebillot@buckinstitute.org
415-209-2080
Buck Institute for Age Research
Source:Eurekalert

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