Navigation Links
Scientists spy enzyme that makes us unique
Date:10/17/2007

Have you ever wondered why you inherited your mothers smile but not your fathers height? Researchers at the Universities of Leeds and Dundee are one step closer to unravelling how nature combines both maternal and paternal DNA to create genetically unique offspring.

In a world first, Leeds researchers Professor Simon Phillips, Dr Stephen Carr and Dr Jonathan Hadden, together with Professor David Lilley at Dundee, have mapped the 3 dimensional structure of an enzyme responsible for splitting DNA strands a process at the heart of human individuality.

The discovery of the T7 endonuclease 1 enzymes structure was made by using x-ray crystallography techniques. The enzyme is derived from a bacteriophage a naturally occurring virus-like agent that attacks bacteria but the molecular processes are expected to be similar in other organisms, including humans.

Whilst the enzyme was known to play a central role, its physical structure, which is crucial to understanding the splitting process, has never been seen before. Weve now got a 3D picture of it at work, and seen it at the point at which it is about to cut through the DNA strands. This is a major breakthrough in investigating the fundamental mechanisms at work behind the formation of a persons DNA and how viruses replicate their DNA in the body, says Professor Phillips.

In humans, this process starts at conception when maternal and paternal DNA strands join together at random points in their sequence(1). Enzymes such as T7 endonuclease 1 are then responsible for severing the strands at this junction, thus creating a third, unique DNA sequence for the offspring.

However, Professor Phillips says it will be some time before this process can be observed in humans. Its too important a discovery to rush. Our next step is to examine the process in a more complex system than bacteriophage, such as yeast, he says.


'/>"/>

Contact: Clare Elsley
clare@campuspr.co.uk
44-011-325-89880
University of Leeds
Source:Eurekalert

Page: 1

Related biology news :

1. Wisconsin scientists grow critical nerve cells
2. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
3. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
4. UAB scientists discover the origin of a mysterious physical force
5. Fox Chase Cancer Center scientists identify immune-system mutation
6. Scientists Replicate Hepatitis C Virus in Laboratory
7. Scientists detect probable genetic cause of some Parkinsons disease cases
8. Scientists find missing enzyme for tuberculosis iron scavenging pathway
9. Scientists seek answers on what activates deadly anthrax spores
10. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
11. Scientists collaborate to assess health of global environment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/20/2016)... -- VoiceIt is excited to announce its new marketing ... working together, VoiceIt and VoicePass will offer an ... slightly different approaches to voice biometrics, collaboration between ... Both companies ... "This marketing and technology partnership allows VoiceIt ...
(Date:5/3/2016)... , May 3, 2016  Neurotechnology, a provider ... MegaMatcher Automated Biometric Identification System (ABIS) , ... multi-biometric projects. MegaMatcher ABIS can process multiple complex ... any combination of fingerprint, face or iris biometrics. ... SDK and MegaMatcher Accelerator , which ...
(Date:4/26/2016)... 27, 2016 Research and ... Biometrics Market 2016-2020"  report to their offering.  , ... The analysts forecast the global multimodal biometrics ... during the period 2016-2020.  Multimodal biometrics ... such as the healthcare, BFSI, transportation, automotive, and ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... - FACIT has announced the creation of a ... Propellon Therapeutics Inc. ("Propellon" or "the Company"), to ... of first-in-class WDR5 inhibitors for the treatment of ... an exciting class of therapies, possessing the potential ... patients. Substantial advances have been achieved with the ...
(Date:6/23/2016)... June 23, 2016 Houston Methodist Willowbrook ... Cy-Fair Sports Association to serve as their official ... Houston Methodist Willowbrook will provide sponsorship support, athletic ... with association coaches, volunteers, athletes and families. ... Cy-Fair Sports Association and to bring Houston Methodist ...
(Date:6/23/2016)... SANTA MONICA, Calif. , June 23, 2016  The Prostate Cancer ... to pioneer increasingly precise treatments and faster cures for prostate cancer. Members of ... 77 institutions across 15 countries. Read More About the ... ... ...
(Date:6/23/2016)... 23, 2016   EpiBiome , a precision microbiome ... in debt financing from Silicon Valley Bank (SVB). The ... to advance its drug development efforts, as well as ... "SVB has been an incredible strategic partner to ... traditional bank would provide," said Dr. Aeron Tynes ...
Breaking Biology Technology: