Navigation Links
Scientists spy enzyme that makes us unique
Date:10/17/2007

Have you ever wondered why you inherited your mothers smile but not your fathers height? Researchers at the Universities of Leeds and Dundee are one step closer to unravelling how nature combines both maternal and paternal DNA to create genetically unique offspring.

In a world first, Leeds researchers Professor Simon Phillips, Dr Stephen Carr and Dr Jonathan Hadden, together with Professor David Lilley at Dundee, have mapped the 3 dimensional structure of an enzyme responsible for splitting DNA strands a process at the heart of human individuality.

The discovery of the T7 endonuclease 1 enzymes structure was made by using x-ray crystallography techniques. The enzyme is derived from a bacteriophage a naturally occurring virus-like agent that attacks bacteria but the molecular processes are expected to be similar in other organisms, including humans.

Whilst the enzyme was known to play a central role, its physical structure, which is crucial to understanding the splitting process, has never been seen before. Weve now got a 3D picture of it at work, and seen it at the point at which it is about to cut through the DNA strands. This is a major breakthrough in investigating the fundamental mechanisms at work behind the formation of a persons DNA and how viruses replicate their DNA in the body, says Professor Phillips.

In humans, this process starts at conception when maternal and paternal DNA strands join together at random points in their sequence(1). Enzymes such as T7 endonuclease 1 are then responsible for severing the strands at this junction, thus creating a third, unique DNA sequence for the offspring.

However, Professor Phillips says it will be some time before this process can be observed in humans. Its too important a discovery to rush. Our next step is to examine the process in a more complex system than bacteriophage, such as yeast, he says.


'/>"/>

Contact: Clare Elsley
clare@campuspr.co.uk
44-011-325-89880
University of Leeds
Source:Eurekalert

Page: 1

Related biology news :

1. Wisconsin scientists grow critical nerve cells
2. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
3. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
4. UAB scientists discover the origin of a mysterious physical force
5. Fox Chase Cancer Center scientists identify immune-system mutation
6. Scientists Replicate Hepatitis C Virus in Laboratory
7. Scientists detect probable genetic cause of some Parkinsons disease cases
8. Scientists find missing enzyme for tuberculosis iron scavenging pathway
9. Scientists seek answers on what activates deadly anthrax spores
10. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
11. Scientists collaborate to assess health of global environment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2017)... CENTRE, N.Y. , March 27, 2017 /PRNewswire-USNewswire/ ... Healthcare Information and Management Systems Society (HIMSS) Analytics ... Outpatient EMR Adoption Model sm . In addition, ... 12% of U.S. hospitals using an electronic medical ... CHS for its high level of EMR usage ...
(Date:3/23/2017)... India , March 23, 2017 The report "Gesture ... Touchless Biometric), Industry, and Geography - Global Forecast to 2022", published by MarketsandMarkets, ... at a CAGR of 29.63% between 2017 and 2022. ... ... ...
(Date:3/22/2017)... NEW YORK , March 21, 2017 /PRNewswire/ ... Customer Marketing Cloud used by retailers such as ... in its platform — Product Recommendations and Replenishment. Using ... to give more personalized product and replenishment recommendations ... purchases, but also on predictions of customer intent ...
Breaking Biology News(10 mins):
(Date:5/18/2017)... San Diego, California (PRWEB) , ... May 18, ... ... looking for team-building activities. The Tapas Cooking Challenge is a two-hour team-building ... from a delicious menu created by Chef Jodi Abel, which include items, such ...
(Date:5/18/2017)... ... 17, 2017 , ... USDM Life Sciences , the ... sciences and healthcare industries, is honored that Jay Crowley was selected ... Brussels, Belgium. , Crowley played a crucial role in the development of the ...
(Date:5/16/2017)... ... May 16, 2017 , ... Genedata, ... Genedata Screener User Group Meetings, which will be held in Boston, ... share best practices in screening data analysis and learn about the latest advances ...
(Date:5/16/2017)... ... (PRWEB) May 16, 2017 , ... ... of Orthopaedic Surgeons (CAOS), long-standing development partners Invibio Biomaterial Solutions, UK, and ... surgery workshop to help expand knowledge of the implantation of Double Medical’s ...
Breaking Biology Technology: