Navigation Links
Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
Date:8/13/2007

Monday, August 13, 2007 Today, researchers report for the first time that genetic variants in mitochondriaenergy-producing structures harboring DNA that are inherited only from the motherare directly linked to metabolic markers for type 2 diabetes. The study, which highlights the role of mitochondrial genome variation in the pathogenesis of common diseases, is published online in Genome Research (www.genome.org).

According to the Centers for Disease Control, 7% of the U.S. population has diabetes, and 90-95% of those cases are classified as type 2 diabetes. Type 2 diabetes is caused by external factors such as diet and exercise, and is influenced by several genes. While most of the genes known to be involved in diabetes susceptibility are located in the nuclear genome, a recent study estimated that more than 20% of type 2 diabetes cases may involve mutations in the mitochondrial genome.

In the study published today, the scientists compared two different rat strains; the strains possessed virtually identical nuclear genomes but different mitochondrial genomes. This eliminated any complicating effects due to environmental factors or variation in the nuclear genome. Any differences observed between the two rat strains could be attributed to variation in the mitochondria.

When comparing the two rat strains, the researchers found that the two strains exhibited significant differences related to energy metabolism and storage. One rat strain exhibited impaired glucose tolerance, reduced muscle glycogen synthesis, decreased skeletal muscle ATP (energy) levels, and decreased activity of an energy-producing enzyme called cytochrome c oxidase, when compared to the second rat strain. These metabolic characteristics are typical of diabetic individuals.

The researchers then obtained DNA sequences from mitochondria of both rat strains, and found DNA variants in genes that encode for proteins involved in energy production. Thus, for the first time, they were able to directly link inherited variation in the mitochondrial genome to metabolic markers for type 2 diabetes.

Our study highlights the role of mitochondrial DNA variation in common genetic diseases, says Dr. Theodore Kurtz, the lead investigator on the project. In addition, the animal models developed in this study will open the door for future studies in which the effects of mitochondrial genome variation can be investigated on fixed nuclear genetic backgrounds.


'/>"/>

Contact: Maria Smit
smit@cshl.edu
516-422-4127
Cold Spring Harbor Laboratory
Source:Eurekalert

Related biology news :

1. Wisconsin scientists grow critical nerve cells
2. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
3. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
4. UAB scientists discover the origin of a mysterious physical force
5. Fox Chase Cancer Center scientists identify immune-system mutation
6. Scientists Replicate Hepatitis C Virus in Laboratory
7. Scientists detect probable genetic cause of some Parkinsons disease cases
8. Scientists find missing enzyme for tuberculosis iron scavenging pathway
9. Scientists seek answers on what activates deadly anthrax spores
10. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
11. Scientists collaborate to assess health of global environment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/4/2019)... ... December 03, 2019 , ... Genedata, the leading provider of ... clinical-stage immuno-oncology company developing therapies to fight cancer, has chosen Genedata Biologics ... the platform to support immunotherapy and vaccine pipeline programs across their global organization. ...
(Date:11/27/2019)... (PRWEB) , ... November 25, 2019 , ... Though the ... for the more than 55 million travelers expected to hit the roads and the ... application worth it’s weight in truffle oil will offer a simple design, mouth-watering pictures ...
(Date:11/20/2019)... ... , ... BioInformatics Inc., part of Science and Medicine Group, the leading research ... the Life Science Industry Awards for the most innovative new products in 2019. , ... Most Innovative New Product – Cell Biology, Fluidigm (Gold ...
Breaking Biology News(10 mins):
(Date:12/30/2019)... (PRWEB) , ... December 30, 2019 , ... ... built, helium-based leak testing instruments for the Pharmaceutical, Biotechnology, Medical Device and Food ... 1.11.19 21 CFR Part 11 compliant software program specific to the custom-built helium ...
(Date:12/18/2019)... ... December 17, 2019 , ... Philadelphia IP law firm ... it has hired Dr. Alia Orbin, Ph.D., J.D., an experienced registered patent attorney ... filing and prosecution of patent applications related to pharmaceutical sciences, organic and inorganic ...
(Date:12/4/2019)... ... December 03, 2019 , ... ... today announced a partnership with the Recombinant Antibody Network (RAN), a consortium of ... San Francisco (UCSF) with a common goal to generate recombinant antibodies at a ...
(Date:12/2/2019)... ... ... Registration is now open for the American Society of Gene & Cell ... May 12-15, 2020, in Boston. The meeting is the premier event in the field ... stakeholders with the goal of advancing gene and cell therapies to alleviate human disease. ...
Breaking Biology Technology: