Navigation Links
Scientists seek out cancer cells hiding from treatment
Date:1/15/2013

Scientists hope to improve leukaemia treatment by investigating how cancer cells use 'hiding places' in the body to avoid chemotherapy drugs.

Each year 300 British children are diagnosed with acute lymphoblastic leukaemia, a cancer of the blood. The majority respond well to current therapies, but the disease returns in a quarter of patients. The long term outlook for adults is much worse, with initial treatments being effective in fewer than half of all patients.

Now, researchers from Imperial College London will begin a three year project to explore how some cancer cells evade treatment, thanks to new funding from blood cancer charity Leukaemia & Lymphoma Research.

Lead researcher, Dr Cristina Lo Celso, Lecturer in Immunology in Imperial's Department of Life Sciences, said: "We believe that some evasive cancer cells hide in protective compartments inside the body while patients receive treatment. If we understand where the cancer cells hide, we will be able to develop better ways to treat patients by eliminating all cancer cells and avoiding disease relapse."

Blood cells are produced in the bone marrow, where they grow and take on a variety of forms within compartments called niches inside bones. Dr Lo Celso's team believe that in the bones of Leukaemia patients, some of these compartments have been 'hijacked' by leukaemia cells, where they serve as effective hiding places during treatment. "Once we can see how this happens drugs can be developed that target the hiding places. This will have a dramatic impact on the design of new drugs for blood cancers like acute lymphoblastic leukaemia," she said.

Dr Lo Celso and colleague Dr Edwin Hawkins will use high powered microscopes in Imperial's Facility for Imaging by Light Microscopy (FILM) to observe cancer cells using fluorescent light. They will use this technique to track the movement of the evasive leukaemia cells in laboratory mice and hope to learn where these cells go during cancer treatment.

Professor Chris Bunce, Research Director at Leukaemia & Lymphoma Research, said: "Leukaemia occurs when the machinery that controls how blood cells grow and die breaks down. We now know that both normal blood cells and leukaemia cells are produced by a small number of stem cells that live inside compartments in our bone marrow. Understanding how these leukaemia cells hide from powerful anti-cancer drugs is vital to creating treatments for patients that will work faster and prevent the disease from returning."


'/>"/>

Contact: Simon Levey
s.levey@imperial.ac.uk
44-020-759-46702
Imperial College London
Source:Eurekalert

Related biology news :

1. Stanford scientists develop gene therapy approach to grow blood vessels in ischemic limbs
2. Queens scientists seek vaccine for Pseudomonas infection
3. Scientists produce eye structures from human blood-derived stem cells
4. American Society of Plant Biologists honors early career women scientists
5. Brandeis scientists win prestigious prize for circadian rhythms research
6. Scientists discover new method of proton transfer
7. Salk scientists open new window into how cancers override cellular growth controls
8. WileyChina.com - Now Featuring Bespoke Pages for China’s Life Scientists
9. Scientists win $2 million to study new pathway in development and maintenance of lymphoma
10. UGA scientists reveal genetic mutation depicted in van Goghs sunflower paintings
11. Genetic mutation depicted in van Goghs sunflower paintings revealed by scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/9/2016)... 9, 2016 Nigeria ... more than 23,000 public service employees either did not ... their salary unlawfully.    --> Nigeria ... that more than 23,000 public service employees either did ... receiving their salary unlawfully.    --> DERMALOG, ...
(Date:3/3/2016)... 2016  FlexTech, a SEMI Strategic Association Partner, awarded ... & Development, Leadership in Education, and, in a category ... th year of the FLEXI Awards and the ... from past years . Judging was done on ... of criteria, by a panel of non-affiliated, independent, industry ...
(Date:3/2/2016)... , March 2, 2016 ... the addition of the  "Global Biometrics Market ... offering.  ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , , Global ... grow at a CAGR of around 27% ... ) has announced the addition of the  ...
Breaking Biology News(10 mins):
(Date:4/28/2016)... Q BioMed Inc. (OTCQB:QBIO), ...  was featured in an article he wrote on ... To Tread: http://www.lifescienceleader.com/doc/accelerators-enter-when-vcs-fear-to-tread-0001 ... an essential business journal for life science executives ... Big Pharmas. Their content is designed to inform ...
(Date:4/28/2016)... ... April 28, 2016 , ... Morris Midwest ( http://www.morrismidwest.com ), ... manufacturers at its Maple Grove, Minnesota technical center, May 11-12. The event ... Almost 20 leading suppliers of tooling, accessories, software and other related technology ...
(Date:4/27/2016)... NY (PRWEB) , ... April 27, 2016 , ... ... it. Touch screen mobile devices with fingerprint recognition for secure access, voice ... are only a few ways consumers are interacting with biometrics technology today. ...
(Date:4/27/2016)... (PRWEB) , ... April 27, 2016 , ... ... that Jon Clark has joined the company as an Expert Consultant. Mr. ... for industry collaborations and managing the development of small molecule monographs based on ...
Breaking Biology Technology: