Navigation Links
Scientists reveal the key mechanisms for affinity between transient binding proteins
Date:7/2/2008

This release is available in Spanish.

Most of the functions performed by a cell are the result of interactions between proteins, which recognise their binding partner by affinity features localized on the protein surface. There are many kinds of interactions; however, the most complicated to study from the perspective of structural biology are those which are transient. This type of interaction is brief and occurs through a large section of the protein surface- the globular domain -, and a very small section of the surface of another proteins, the so-called lineal motif or peptide. The difficulty lies in the fact that these relations are of short duration and there are few crystallized peptide structures. Researchers at the Institute for Research in Biomedicine (IRB Barcelona) have performed the first computational analysis of transient interactions between proteins in order to reveal what determines their recognition as ideal partners and have unveiled part of the molecular mechanisms involved in the specificity of this binding. The results of this study have been published in the scientific journal PLoS One.

"Knowing what determines protein-protein binding may have implications, for example, in the design of new drugs", explains Patrick Aloy, ICREA research professor at IRB Barcelona, "however, we currently know very little about this type of binding". These kinds of interactions occur mainly between proteins involved in signalling pathways and regulatory networks, and they serve to translate and transmit extracellular signals to the cell nucleus.

The context is relevant

In Patrick Aloy's Structural Biology Laboratory they have detected all interactions possible between the globular domain and peptide by exploring the 45,000 3D protein structures currently available on the international database PDB (Protein Data Base)
'/>"/>

Contact: Snia Armengou
sonia.armengou@irbbarcelona.org
34-934-037-255
Institute for Research in Biomedicine (IRB Barcelona)
Source:Eurekalert

0

GOOD

Page: 1 2

Related biology news :

1. Tree-killing fungus officially named by scientists
2. Food scientists confirm commercial product effectively kills bacteria in vegetable washwater
3. Scientists may have solved an ecological riddle
4. Indiana U scientists uncover potential key to better drugs to fight toxoplasmosis parasite
5. New bee checklist lets scientists link important information about all bee species
6. Scientists discover DNA knot keeps viral genes tightly corked inside shell
7. Scientists find potential protein biomarkers for growth hormone
8. Scientists confirm that parts of earliest genetic material may have come from the stars
9. Scientists find 245 million-year-old burrows of land vertebrates in Antarctica
10. Brain stem cells can be awakened, say Schepens scientists
11. Scientists demonstrate feasibility of preventing malaria parasite from becoming sexually mature
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/19/2013)... bred specifically for human consumption qualifies as a gluten-free ... disease (CD), scientists have confirmed in a study published ... . , Joyce Irene Boye and colleagues point ... United States alone have CD. They develop gastrointestinal and ... grains that contain gluten-related proteins. Boye,s team sought to ...
(Date:6/19/2013)... , June 19, 2013  New York College of ... United States Patent and Trademark Office for detecting biometric ... reflect whether guards have been injured, attacked or killed. ... portfolio under the Intellectual Properties Agreements of New York ... , President of New York ...
(Date:6/19/2013)... floods across the Midwest are expected to contribute to ... Mexico "dead zone," according to a University of Michigan ... along with one for the Chesapeake Bay. , The ... Oceanic and Atmospheric Administration, calls for an oxygen-depleted, or ... which would place it among the 10 largest on ...
Breaking Biology News(10 mins):New Technology Using Biometrics Detects If Security Guards Are Attacked, Injured Or Killed 2New Technology Using Biometrics Detects If Security Guards Are Attacked, Injured Or Killed 3New Technology Using Biometrics Detects If Security Guards Are Attacked, Injured Or Killed 4U-M researcher and colleagues predict possible record-setting Gulf of Mexico 'dead zone' 2U-M researcher and colleagues predict possible record-setting Gulf of Mexico 'dead zone' 3U-M researcher and colleagues predict possible record-setting Gulf of Mexico 'dead zone' 4
... renews itself may be simpler than what scientists had been ... of The Journal of Biological Chemistry, provides new information on ... significantly affect the way physicians make livers regrow in patients ... , "The human liver is one of the few organs ...
... do it: they simply grab carbon dioxide out of the ... as photosynthesis, the plants use light as their energy source. ... as a carbon source for their synthetic reactions, but it ... Antonietti at the Max Planck Institute for Colloids and Interfaces ...
... inhibitor of a protein that plays key roles in ... the inhibitor can halt the growth of tumors in ... are reported in companion papers reported by two collaborating ... the Research Institute of Molecular Pathology in Vienna, and ...
Cached Biology News:Liver regeneration may be simpler than previously thought 2Liver regeneration may be simpler than previously thought 3Progress toward artificial photosynthesis? 2New protein inhibitor impedes growth of cancerous cells 2
(Date:6/19/2013)... Bayer CropScience will honor Illinois beekeeper Steve ... Leadership Award. The award will be announced at Bayer’s ... D.C., an event where supporters of pollinator health celebrate ... , The Bayer Bee Care Community Leadership Award ... honey bee colony to benefit their community. Applicants are ...
(Date:6/19/2013)... -- Biotechnology industry pioneer Amgen (NASDAQ: ... BlackLine Systems  and enterprise application software leader SAP ... next week entitled "No Account Left Behind!  ... Help Keep Its Account Reconciliations in Good Shape ."  ... The webinar, geared at finance, accounting, audit and compliance managers ...
(Date:6/19/2013)... Indiana (PRWEB) June 19, 2013 ... joined the speaking faculty at 2013’s BioLogistics Summit ... The conference, coordinated by Cold Chain IQ and ... biologics. This “complexity” is, in part, attributed to ... , “Implicit within these trends is an ...
(Date:6/19/2013)... Applied Rigaku Technologies, Inc. is pleased to publish ... sulfur in ultra-low sulfur diesel (ULSD) using the new ... . The analysis detailed in Rigaku Application Note 1272 ... International Standard specifies an energy dispersive X-ray fluorescence (EDXRF) ... automotive gasoline. , Regulations around the world have limited ...
Breaking Biology Technology:Community Mentor Wins Inaugural Bayer CropScience Bee Care Leadership Award 2Community Mentor Wins Inaugural Bayer CropScience Bee Care Leadership Award 3Community Mentor Wins Inaugural Bayer CropScience Bee Care Leadership Award 4Amgen Joins BlackLine Systems, SAP for Webinar on Automating Account Reconciliations 2Amgen Joins BlackLine Systems, SAP for Webinar on Automating Account Reconciliations 3Amgen Joins BlackLine Systems, SAP for Webinar on Automating Account Reconciliations 4BioConvergence® Presents at BioLogistics Summit on Risk Matrix for Biosamples during Shipment 2Rigaku Publishes New Application Note for Analysis of ULSD Per ISO 13032 2
... in early-stage Wisconsin companies topped $100 million last year, but ... interesting investment patterns. , ,The figures were outlined in a ... for 2006, which was produced by NorthStar Economics , ... Department of Financial Institutions . , ,While the total ...
... to add the Olympics to their list of great ... more than just a third-party Wi-Fi agreement. The City ... Wi-Fi and into the real competition of global cities ... Look around, Wi-Fi projects are failing , ,Anyone ...
... This is part II of a two-part column on ... focused on the recent controversy over Avandia, GlaxoSmithKline's diabetes drug. ... be so deeply integral to the system that it might be ... For much of its history, the Food and Drug Administration's ...
Cached Biology Technology:Breaking down Wisconsin's angel capital numbers 2Breaking down Wisconsin's angel capital numbers 3No network infrastructure, no Olympics, no nothing 2No network infrastructure, no Olympics, no nothing 3No network infrastructure, no Olympics, no nothing 4No network infrastructure, no Olympics, no nothing 5No network infrastructure, no Olympics, no nothing 6Reforming FDA: Focus on safety, let market judge efficacy 2Reforming FDA: Focus on safety, let market judge efficacy 3Reforming FDA: Focus on safety, let market judge efficacy 4Reforming FDA: Focus on safety, let market judge efficacy 5Reforming FDA: Focus on safety, let market judge efficacy 6
... sensitive silver stain. Reproducible ... baths or reversers needed. ... polysaccharides. Linear protein-to-stain color ... multiple gels per tray. ...
Rabbit polyclonal to Quinaldic Acid ( Abpromise for all tested applications). Antigen: Synthetic peptide Quinaldic Acid conjugated to a protein carrier....
A set of five peptides which can be used to calibrate a Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) or Electrospray Ionization (ESI) mass spectrometer....
... CLS number is a new ... match Cornings product number. If ... order under the old Sigma-Aldrich ... service for assistance. ID clarifier: ...
Biology Products: