Navigation Links
Scientists reveal potential link between brain development and breast cancer gene
Date:4/8/2014

lls, and other core functions.

How exactly was the absence of BRCA1 leading to such a neural catastrophe? In a previous paper, the team showed that without the protein coded by the BRCA1 gene, DNA is not packaged properly, becoming fragile and more likely to break during DNA replication. In this new paper, the researchers reveal more about that mechanism, showing that without the protective ability of BRCA1, breaks in the DNA strands go unfixed, prompting the molecule ATM kinase to activate a cellular "suicide" pathway involving a protein called p53. This pathway helps to halt the replication of damaged cells and is important in cancer research.

"BRCA1 acts by conferring stability to the DNA and preventing it from breaking," says Carlos G. PerezGarcia, a Salk researcher in the Molecular Neurobiology Lab. "BRCA1 is important for all healthy cells."

When the researchers eliminated both BRCA1 and p53, they found the neurons grew at a normal rate, but still disorderly, with cells pointed in the wrong direction.

"In this scenario, we recover a lot of neurons but there's still a lot of abnormalities, such as cells that are sideways and pointed the wrong direction," says Gerald Pao, who, along with Quan Zhu and PerezGarcia, is a primary contributor to the paper and Salk researcher.

This observation led the team to propose that BRCA1 has an additional role in assisting neurons in orienting: the gene acts on the centromere of DNAessentially an anchor for the chromosome arms essential in cell replicationto tell the new cell in which direction to grow, providing guidance in developing the brain's organized layers.

"It is remarkable that BRCA1 has such a significant effect on the brain, especially size. This work leads us to a better understanding of how to protect neurons," says Verma, who is also the Irwin and Joan Jacobs Cha
'/>"/>

Contact: Chris Emery
Cemery@salk.edu
301-873-6952
Salk Institute
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Stanford scientists develop gene therapy approach to grow blood vessels in ischemic limbs
2. Queens scientists seek vaccine for Pseudomonas infection
3. Scientists produce eye structures from human blood-derived stem cells
4. American Society of Plant Biologists honors early career women scientists
5. Brandeis scientists win prestigious prize for circadian rhythms research
6. Scientists discover new method of proton transfer
7. Salk scientists open new window into how cancers override cellular growth controls
8. WileyChina.com - Now Featuring Bespoke Pages for China’s Life Scientists
9. Scientists win $2 million to study new pathway in development and maintenance of lymphoma
10. UGA scientists reveal genetic mutation depicted in van Goghs sunflower paintings
11. Genetic mutation depicted in van Goghs sunflower paintings revealed by scientists
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists reveal potential link between brain development and breast cancer gene
(Date:4/27/2015)... 2015  For more than four decades, AUVSI,s ... the premier worldwide event for the unmanned land, sea, ... event for any local, national, or trade news organization ... markets and current applications of unmanned technologies. The conference ... $48 billion industry, and how it will soon impact ...
(Date:4/21/2015)... , April 21, 2015 ... evolving government policies are boosting access control systems market ... According to a recently published report by TechSci ... 2020 ", the access control systems market in ... USD1.2 billion by 2020.The access control systems market in ...
(Date:4/17/2015)... , April 17, 2015 ... security concerns, and technological advancement to drive biometric ... until 2020   According to ... Arabia Biometric Systems Market Forecast &  Opportunities, 2020 ", biometric systems market ... projected to register growth at CAGR of over ...
Breaking Biology News(10 mins):UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 4UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 5Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3
... Gesellschaft fuer Naturforschung will collaborate on the publication ... Palaeobiodiversity and Palaeoenvironments and ... maximum exposure through Springer,s abstracting and indexing services ... published in both electronic and print versions. ...
... February 23, 2009 Great Ape Trust of ... respected orangutan experts have edited a book set for ... the first time, compares data collected at every known ... differences and similarities among orangutan species, subspecies and populations. ...
... emission by living organisms, bioluminescence, is quite common, especially ... generated by chemical reactions in which oxygen molecules play ... reactions take place in special luminescent cells called photocytes. ... the intensity of light is regulated by nerve impulses, ...
Cached Biology News:Springer and Senckenberg society to collaborate on life sciences and geosciences journals 2New book expands field data available on orangutans 2New book expands field data available on orangutans 3New light shed on marine luminescence 2
(Date:5/5/2015)... , May 5, 2015  A group of ... of the Coma Research Institute, a non-profit organization dedicated ... and families suffering from disorders of consciousness.  ... http://photos.prnewswire.com/prnh/20150504/213779LOGO   ... of consciousness, in which no voluntary actions can be ...
(Date:5/5/2015)... 2015 CytomX, a biotechnology company developing Probody™ ... Sean McCarthy , D. Phil., chief executive officer, ... New York at 1:15 p.m. ... an overview of CytomX,s Probody pipeline, including the company,s ... About CytomX Therapeutics CytomX Therapeutics develops Probody™ ...
(Date:5/5/2015)... WASHINGTON , May 5, 2015  Indianapolis-based ... adoption of its innovative line of products including ... solution for atraumatically accessing deep-seated brain abnormalities and ... have been completed at more than 50 institutions ... The technology has also been included in 12 ...
(Date:5/4/2015)... May 4, 2015 /PRNewswire/ - JSS Medical Research Inc., a ... that it concluded the acquisition of Max Neeman International (MNI), with ... regional offices are located in Ahmedabad, Bangalore , ... Through a US subsidiary, a regional office is located ... is supported by the recent equity investment transaction into JSS with ...
Breaking Biology Technology:Biotechnology Executives and Medical Doctors Team Up to Tackle Coma and Disorders of Consciousness 2Biotechnology Executives and Medical Doctors Team Up to Tackle Coma and Disorders of Consciousness 3Biotechnology Executives and Medical Doctors Team Up to Tackle Coma and Disorders of Consciousness 4Biotechnology Executives and Medical Doctors Team Up to Tackle Coma and Disorders of Consciousness 5NICO Corporation Gains Market Expansion after Multiple Published Clinical Articles Support Access Technology for Deep Brain Lesions 2NICO Corporation Gains Market Expansion after Multiple Published Clinical Articles Support Access Technology for Deep Brain Lesions 3JSS Medical Canada widens its global presence across Asia/Pacific region 2JSS Medical Canada widens its global presence across Asia/Pacific region 3JSS Medical Canada widens its global presence across Asia/Pacific region 4
... graphene was first isolated in 2004 with the help ... material to discover its potential applications. A single layer ... to biosensors to flexible displays, graphene is strong, light, ... what can we do with this new material? As ...
... and SYDNEY, Nov. 18, 2010 HeartWare International, Inc. ... innovator of less invasive, miniaturized circulatory support technologies that ... announced that CEO Doug Godshall is scheduled to make ... Health Care Conference on Tuesday, November 30, at 3:00 ...
... Nov. 18, 2010 Reportlinker.com announces that a ... catalogue: Global Bladder Cancer Therapeutics ... This report analyzes the worldwide markets for ... provides separate comprehensive analytics for US, Japan, Europe, ...
Cached Biology Technology:Doctoral candidate publishes on graphene's potential with NSF support 2Doctoral candidate publishes on graphene's potential with NSF support 3Doctoral candidate publishes on graphene's potential with NSF support 4HeartWare to Present at the 22nd Annual Piper Jaffray Health Care Conference 2Reportlinker Adds Global Bladder Cancer Therapeutics Industry 2Reportlinker Adds Global Bladder Cancer Therapeutics Industry 3Reportlinker Adds Global Bladder Cancer Therapeutics Industry 4Reportlinker Adds Global Bladder Cancer Therapeutics Industry 5Reportlinker Adds Global Bladder Cancer Therapeutics Industry 6Reportlinker Adds Global Bladder Cancer Therapeutics Industry 7Reportlinker Adds Global Bladder Cancer Therapeutics Industry 8Reportlinker Adds Global Bladder Cancer Therapeutics Industry 9Reportlinker Adds Global Bladder Cancer Therapeutics Industry 10Reportlinker Adds Global Bladder Cancer Therapeutics Industry 11Reportlinker Adds Global Bladder Cancer Therapeutics Industry 12Reportlinker Adds Global Bladder Cancer Therapeutics Industry 13
... LAS-3000 imaging system combines new CCD ... interface, providing significantly improved system sensitivity ... The system is especially dedicated to ... system for Western blotting applications.,Fuiji's LAS-3000 ...
... LAS-3000mini is a compact image analysis ... and the perfect standard system for ... provides significantly improved system sensitivity for ... standards validate that Fujis LAS-3000 is ...
... 50 assays. The TUNEL-based assay kit ... control cells for convenient detection of DNA ... The assay offers an one-step labeling of ... is a hallmark of apoptosis in mammalian ...
SDS-OutT Precipitation Reagent...
Biology Products: