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Scientists reveal new targets for anti-angiogenesis drugs
Date:8/16/2010

found that preventing galectin-3 from binding with the integrins reduced angiogenesis," said first author Anna Markowska, a PhD student in the biochemistry program at the Sackler School of Graduate Biomedical Sciences at Tufts.

"By deciphering the mechanism of galectin-3 action, we were able to establish more than one therapeutic target. The more we know about how this pathway works, the more options we have for potential treatments," said Panjwani.

Panjwani's lab is dedicated to understanding the cell biological and biochemical mechanisms of wound healing and angiogenesis, specifically for the purpose of developing improved treatments for blinding eye diseases. Panjwani's research is also focused on Acanthamoeba keratitis, a rare and painful parasitic infection of the cornea that can affect contact lens wearers. She is currently working on strategies to protect against the infection and is developing a test that identifies at-risk individuals by sampling their tears.


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Contact: Siobhan Gallagher
617-636-6586
Tufts University, Health Sciences
Source:Eurekalert  

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