Navigation Links
Scientists reveal important clues to how bacteria and viruses are identified as enemies
Date:9/30/2010

A new research report in the October 2010 print issue of the Journal of Leukocyte Biology (http://www.jleukbio.org) sheds important light on how our immune systems detect invading organisms to be destroyed and removed from our bodies. The information from this research should ultimately help lead to the development of new drugs and treatments that allow health care providers to prevent runaway immune reactions that can have devastating consequences for people.

"Our study helps us to understand exactly how the immune system is activated when it comes across infection from bacteria or viruses," said Melanie J. Scott, M.D., Ph.D., an author of the research report from the Department of Surgery at the University of Pittsburgh, Pennsylvania. "The more information we have about how this process works, the more likely we are to be able to help our immune systems fight off attacks from infections."

To make this discovery, scientists examined the production of a specific part of the complement system (called "factor B") in macrophages, an immune cell that both attacks foreign invaders and marks them for death by other types of immune cells. The researchers wanted to know if a molecule found on the outside of bacteria (lipopolysaccharide) or a synthetic version of a molecule found in some viruses (polyI:C) would stimulate factor B production by macrophages. The levels of factor B produced inside the cell were measured, as was the amount released from the cell. Results showed that lipopolysaccharide used a specific receptor on the outside of cells (TLR4) to produce factor B. polyI:C also stimulated factor B production in macrophages, not through its specific cell surface receptor (TLR3) but through another receptor that is located within cells. This shows that bacteria and viruses can produce similar end results in activating the body's defense systems, but they use different pathways to do the activation.

"As this research shows, the immune system is incredibly complex. It also highlights the redundancy which is vital to our survival," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. "Viruses and bacterial have evolved many strategies to avoid immune responses, but the immune system counters with additional tricks and alternative pathways. This research helps us better understand one very important set of redundant pathways that regulates a key defense mechanism and identifies therapeutic targets for controlling that response."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. Going green: New program provides vital support for plant scientists
2. Notre Dame and Wyoming scientists genetically engineer silkworms to produce artificial spider silk
3. Hepatitis C virus faces new weapon from Florida State scientists
4. Light workout: Stanford scientists use optogenetics to effectively stimulate muscle movement in mice
5. Scientists release first cultivated ohelo berry for Hawaii
6. Fruit flies help Yale scientists sniff out new insect repellents
7. Marine scientists unveil the mystery of life on undersea mountains
8. Scientists uncover process enabling toxoplasmosis parasite to survive homelessness
9. Scientists show Six3 gene essential for retinal development
10. Warrior worms discovered in snails; UCSB scientists see possible biomedical applications
11. Watch your seas: Marine scientists call for European marine observatory network
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/21/2017)... PORTLAND, Ore. , Feb. 22, 2017 /PRNewswire/ ... of Companies (Avamere Health Services, Infinity Rehab, Signature Hospice, ... study that will apply the power of IBM cognitive ... and health centers. By analyzing data streaming from sensors ... into physical and environmental conditions, and obtain deeper learnings ...
(Date:2/16/2017)... SAN FRANCISCO , Feb. 16, 2017 /PRNewswire/ ... research, today announced that it has received Laboratory ... The CAP Accreditation is presented to laboratories that ... and who demonstrate scientifically rigorous processes. ... of excellence in laboratory practices. We,re honored to ...
(Date:2/13/2017)... 2017  RSA Conference -- RSA, a Dell Technologies ... to enhance fraud detection and investigation across digital ... Fraud & Risk Intelligence Suite. The new platform ... insights from internal and external sources as well ... customers from targeted cybercrime attacks. "Fraudsters ...
Breaking Biology News(10 mins):
(Date:2/23/2017)... SAN FRANCISCO , Feb. 23, 2017 /PRNewswire/ ... and Beyond Type 1, a not-for-profit advocacy and education ... announced a grant from Beyond Type 1 to support ... 1 and other insulin-requiring diabetes.  For ... stem cell-derived cell replacement therapies with a focus on ...
(Date:2/22/2017)... ... February 22, 2017 , ... Park Systems , a leader in Atomic ... all SPIE attendees and Park customers on Feb. 27, 2017 from 12-2pm ... Jose Convention Center. The luncheon will feature a talk on Automated AFM for ...
(Date:2/22/2017)... ... 22, 2017 , ... ProMIS Neurosciences (“ProMIS” or the “Company”), ... today announced it has issued a scientific white paper entitled “Results from recent ... of commentaries from ProMIS’s scientific team offering insight into the Company’s product portfolio ...
(Date:2/22/2017)... DES MOINES, Iowa , Feb. 22, 2017 Origin ... an agricultural biotechnology trait and seed provider, and Arcadia ... -based company that develops and commercializes agricultural productivity traits and ... of a key corn biotechnology product developed in China ... completion of global regulatory trials. ...
Breaking Biology Technology: