Navigation Links
Scientists reveal important clues to how bacteria and viruses are identified as enemies
Date:9/30/2010

A new research report in the October 2010 print issue of the Journal of Leukocyte Biology (http://www.jleukbio.org) sheds important light on how our immune systems detect invading organisms to be destroyed and removed from our bodies. The information from this research should ultimately help lead to the development of new drugs and treatments that allow health care providers to prevent runaway immune reactions that can have devastating consequences for people.

"Our study helps us to understand exactly how the immune system is activated when it comes across infection from bacteria or viruses," said Melanie J. Scott, M.D., Ph.D., an author of the research report from the Department of Surgery at the University of Pittsburgh, Pennsylvania. "The more information we have about how this process works, the more likely we are to be able to help our immune systems fight off attacks from infections."

To make this discovery, scientists examined the production of a specific part of the complement system (called "factor B") in macrophages, an immune cell that both attacks foreign invaders and marks them for death by other types of immune cells. The researchers wanted to know if a molecule found on the outside of bacteria (lipopolysaccharide) or a synthetic version of a molecule found in some viruses (polyI:C) would stimulate factor B production by macrophages. The levels of factor B produced inside the cell were measured, as was the amount released from the cell. Results showed that lipopolysaccharide used a specific receptor on the outside of cells (TLR4) to produce factor B. polyI:C also stimulated factor B production in macrophages, not through its specific cell surface receptor (TLR3) but through another receptor that is located within cells. This shows that bacteria and viruses can produce similar end results in activating the body's defense systems, but they use different pathways to do the activation.

"As this research shows, the immune system is incredibly complex. It also highlights the redundancy which is vital to our survival," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. "Viruses and bacterial have evolved many strategies to avoid immune responses, but the immune system counters with additional tricks and alternative pathways. This research helps us better understand one very important set of redundant pathways that regulates a key defense mechanism and identifies therapeutic targets for controlling that response."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. Going green: New program provides vital support for plant scientists
2. Notre Dame and Wyoming scientists genetically engineer silkworms to produce artificial spider silk
3. Hepatitis C virus faces new weapon from Florida State scientists
4. Light workout: Stanford scientists use optogenetics to effectively stimulate muscle movement in mice
5. Scientists release first cultivated ohelo berry for Hawaii
6. Fruit flies help Yale scientists sniff out new insect repellents
7. Marine scientists unveil the mystery of life on undersea mountains
8. Scientists uncover process enabling toxoplasmosis parasite to survive homelessness
9. Scientists show Six3 gene essential for retinal development
10. Warrior worms discovered in snails; UCSB scientists see possible biomedical applications
11. Watch your seas: Marine scientists call for European marine observatory network
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... , March 28, 2017 The ... Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, ... Region - Global Forecast to 2022", published by MarketsandMarkets, ... 2016 and is projected to reach USD 75.64 Billion ... and 2022. The base year considered for the study ...
(Date:3/24/2017)... 24, 2017 The Controller General of Immigration from ... Abdulla Algeen have received the prestigious international IAIR Award for the ... Continue Reading ... ... Controller Abdulla Algeen (small picture on the right) have received the IAIR ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based ... to 2022", published by MarketsandMarkets, the market is expected to be worth USD ... 2022. Continue Reading ... ... ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... and LAGUNA HILLS, Calif. , Oct. ... Cancer Research, London (ICR) and University ... SKY92, SkylineDx,s prognostic tool to risk-stratify patients with multiple myeloma ... MUK nine . The University of Leeds ... partly funded by Myeloma UK, and ICR will perform the ...
(Date:10/10/2017)... ... 2017 , ... San Diego-based team building and cooking events company, Lajollacooks4u, has ... The bold new look is part of a transformation to increase awareness, appeal to ... period. , It will also expand its service offering from its signature gourmet cooking ...
(Date:10/10/2017)... 10, 2017 International research firm Parks Associates announced ... at the TMA 2017 Annual Meeting , October 11 in ... residential home security market and how smart safety and security products impact ... Parks Associates: Smart Home ... "The residential security market has ...
(Date:10/9/2017)... DIEGO , Oct. 9, 2017  BioTech ... biological mechanism by which its ProCell stem cell ... critical limb ischemia.  The Company, demonstrated that treatment ... amount of limbs saved as compared to standard ... the molecule HGF resulted in reduction of therapeutic ...
Breaking Biology Technology: