Navigation Links
Scientists reveal complete structure of HIV's outer shell
Date:1/19/2011

LA JOLLA, CA A team of scientists at The Scripps Research Institute and the University of Virginia has determined the structure of the protein package that delivers the genetic material of the human immunodeficiency virus (HIV) to human cells.

The work is the culmination of studies carried out over the last decade looking at different portions of the cone-shaped container, or the capsid. The final piece of the puzzle, described in an article published in Nature on January 20, 2011, details the structure of the two ends of the cone.

"This paper is a real milestone for research from our group," says the study's senior author Mark Yeager, M.D., Ph.D., a Scripps Research professor and staff cardiologist and chair of the Molecular Physiology and Biological Physics Department at The University of Virginia School of Medicine.

A detailed description of the complete HIV capsid will provide a roadmap for developing drugs that can disrupt its formation and thus prevent infection by HIV.

Assembling the Package

HIV binds to receptors on human cells and then delivers the capsid inside them. Once inside a cell, the capsid comes apart, releasing its precious cargothe virus's genetic material.

HIV then sabotages the cell machinery to make many copies of its genes and proteins. As new viruses are made, the genetic material is packaged into spherical immature capsids that HIV uses to escape from the infected cell. But before these newly released viruses can infect other cells, the immature capsid undergoes a dramatic rearrangement to form the mature, cone-shaped shell.

If formation of the mature capsid is disrupted, the virus is no longer infectious. Thus, new drugs targeting capsid formation could provide valuable additions to the arsenal of existing drugs against HIV.

A "Floppy" Bridge

To develop drugs that disrupt capsid formation, however, scientists first need to kno
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Scientists: Big city life may alter green attitudes
2. Scientists find the master switch for key immune cells in inflammatory diseases
3. MU scientists find new farming method to reduce greenhouse gases, increase farm yields
4. 7 CAMH scientists win Young Investigator awards focused on breakthrough research
5. Inside a snowstorm: Scientists obtain close-up look at Old Man Winter
6. 6 PNNL scientists elected 2010 AAAS Fellows
7. Shellfish safer to eat thanks to breakthrough by Queens scientists
8. UCSB, Texas A&M scientists find methane gas concentrations have returned to near-normal levels
9. Princeton scientists construct synthetic proteins that sustain life
10. Oil spill symposium to convene scientists, media, policymakers and community leaders
11. Canadian marine biodiversity scientists forging strategy for sustainable ocean use
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2014)... in supermarkets to encourage healthier spending habits? A new ... very question by tracking the purchasing records in a ... rate the nutritional value of foods for sale. , ... Just, PhD, and Brian Wansink PhD, author of Slim ... 150 Hannaford Supermarkets in the Northeastern United States between ...
(Date:8/19/2014)... Long-Term Ecological Research and Network-Level Science, , Imagine if ... range of ecosystems was responding to global changes in ... if it coupled multiple decades of information about ecological ... models from dozens of different ecosystem types. , ... Ecological Research (LTER) Network, which will soon celebrate its ...
(Date:8/19/2014)... In many parts of the world, leprosy and ... new cases of leprosy per year, with nearly ... The currently available century-old vaccine Bacille Calmette-Guerin, or ... and leprosy, so a more potent vaccine is ... have found a stronger weapon against both diseases., ...
Breaking Biology News(10 mins):This week from AGU: Long-term ecological research, predicting cholera outbreaks 2New vaccine shows promise as stronger weapon against both tuberculosis and leprosy 2
... Community support of school obesity prevention programs is ... children, according to researchers at the Michael & Susan ... part of The University of Texas Health Science Center ... behavioral sciences at UTHealth,s School of Public Health Austin ...
... chemistry professor David Cramb is a step closer to ... nanoparticles have on human health and the environment. ... and his researchers have developed a methodology to measure ... chicken embryos. Their discovery is published in the March ...
... CA Researchers at Charles Drew University of Medicine ... health of low-birth-weight babies and their parents as part ... associated with low-weight births. Karen Cheng, CDU ... informatics professor, were awarded a $480,000 grant from the ...
Cached Biology News:Community involvement important in fight against childhood obesity, according to UTHealth researchers 2Vigilance needed in nanotechnology 2Charles Drew University, UC Irvine awarded $480,000 grant for research low birth weight infants 2Charles Drew University, UC Irvine awarded $480,000 grant for research low birth weight infants 3
(Date:8/20/2014)... (PRWEB) August 20, 2014 Not long ... E&L studies should be performed late in the development ... known. But current regulatory trends suggest that, like many ... the rise. In recent years, multiple drug sponsors have ... or address specific questions during phase I/II. It’s not ...
(Date:8/20/2014)... WriteResult®, a leading provider of Electronic Patient ... its myPROpad™ ePRO tablet with the addition of a ... most widely used and well-respected Patient Reported Outcome (PRO) ... is used during clinical trials and in other health ... used to demonstrate Health-Related Quality of Life outcomes (HRQoL) ...
(Date:8/19/2014)... Md. (PRWEB) August 19, 2014 ... liquid chromatography systems, Prominence-i and Nexera-i, adding to ... systems. Combining excellent functionality, an intuitive operating environment, ... and a more efficient workflow for conventional to ... feature innovative, intuitive and intelligent design so users ...
(Date:8/19/2014)... IRVINE, Calif. (PRWEB) August 19, 2014 ... Indiegogo campaign to raise $200,000 to fund a ... diagnostic device. , This development is a ... one-size-fits-all model of care to the implementation of ... patient-centric method of practicing medicine. , Indiegogo contributions ...
Breaking Biology Technology:Are Extractable and Leachables going Phase-Appropriate? New Webinar Hosted by Xtalks 2EQ-5D™ Assessment Now Available for iPad 2Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 2Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 3Cellgen Diagnostics Launches Indiegogo Crowdfunding Campaign for DNA Medical Testing Device 2Cellgen Diagnostics Launches Indiegogo Crowdfunding Campaign for DNA Medical Testing Device 3
... Since the cloning of Dolly the Sheep ... been considered a promising way to generate human, patient-specific stem ... has led to efforts to substitute animal oocytes. However, a ... 11, Number 2, 2009 issue of Cloning and Stem ...
... To highlight its 20 years of experience as ... ( www.microtestlabs.com ) is offering free microbial identification ... tests, to eligible attendees visiting the Microtest exhibit, #828, ... highlight Microtest,s wide range of laboratory testing and validation ...
... RGEN ) announced today that the Company ... will present at the BIO CEO and Investor Conference ... at the Waldorf-Astoria Hotel, 301 Park Avenue, New York, ... available via Repligen,s website at www.repligen.com and ...
Cached Biology Technology:Animal Eggs Not Suitable Substitutes to Produce Stem Cells 2Animal Eggs Not Suitable Substitutes to Produce Stem Cells 3Microtest Labs Offers Free Microbial Identification Testing, Free Shipping on Other Tests, to MD&M West Attendees 2Repligen to Present at the BIO CEO & Investor Conference Monday, February 9th, 11:30 a.m. EST 2
... Although there have been many modifications to the ... media, salt solutions still play an important role ... maintain the pH and osmotic balance in the ... and essential inorganic ions, is as valuable today ...
... and Cost effective - Utilizes hands-off homogenization through ... No grinding - Extract DNA without hand ... between samples , Robust tubes - ... homogenize without tube breakage , Flexible ...
A substrate for all AChE-based EIA kits....
... The LXQ linear ion trap mass spectrometer ... analytical laboratory., The LXQ linear ion trap ... and proteomic applications, delivering the fast cycle ... linear ion trap at an attractive price. ...
Biology Products: