Navigation Links
Scientists reproduce evolutionary changes by manipulating embryonic development of mice
Date:7/30/2014

A group of researchers from the University of Helsinki and the Universitat Autnoma de Barcelona have been able experimentally to reproduce in mice morphological changes which have taken millions of years to occur. Through small and gradual modifications in the embryonic development of mice teeth, induced in the laboratory, scientists have obtained teeth which morphologically are very similar to those observed in the fossil registry of rodent species which separated from mice millions of years ago.

To modify the development of their teeth, the team from the Institute of Biotechnology of the University of Helsinki worked with embryonic teeth cultures from mice not coded by the ectodysplasin A (EDA) protein, which regulates the formation of structures and differentiation of organs in the embryo throughout its development. The teeth obtained with these cultures which present this mutation develop into very basic forms, with very uniform crowns. Scientists gradually added different amounts of the EDA protein to the embryonic cells and let them develop.

The researchers observed that the teeth formed with different degrees of complexity in their crown. The more primitive changes observed coincide with those which took place in animals of the Triassic period, some two hundred million years ago. The development of more posterior patterns coincides with the different stages of evolution found in rodents which became extinct already in the Palaeocene Epoch, some 60 million years ago. Researchers have thus achieved experimentally to reproduce the transitions observed in the fossil registry of mammal teeth.

The team of scientists were able to contrast the shape of these teeth with a computer-generated prediction model created by Isaac Salazar-Ciudad, researcher at the UAB and at the University of Helsinki, which reproduces how the tooth changes from a group of equal cells to a complex three-dimensional structure, with the full shape of a molar tooth, calculating the position of space of each cell. The model is capable of predicting the changes in the morphology of the tooth when a gene is modified, and therefore offers an explanation of the mechanisms that cause these specific changes to occur in the shape of teeth throughout evolution.

"Evolution has been explained as the ability of individuals to adapt to their environment in different ways" Isaac Salazar-Ciudad states, "but we do not know why or how individuals differ morphologically. The research helps to understand evolution, in each generation, as a game between the possible variations in form and natural selection".


'/>"/>

Contact: Isaac Salazar-Ciudad
Isaac.salazar@uab.cat
34-935-812-730
Universitat Autonoma de Barcelona
Source:Eurekalert

Related biology news :

1. Stanford scientists develop gene therapy approach to grow blood vessels in ischemic limbs
2. Queens scientists seek vaccine for Pseudomonas infection
3. Scientists produce eye structures from human blood-derived stem cells
4. American Society of Plant Biologists honors early career women scientists
5. Brandeis scientists win prestigious prize for circadian rhythms research
6. Scientists discover new method of proton transfer
7. Salk scientists open new window into how cancers override cellular growth controls
8. WileyChina.com - Now Featuring Bespoke Pages for China’s Life Scientists
9. Scientists win $2 million to study new pathway in development and maintenance of lymphoma
10. UGA scientists reveal genetic mutation depicted in van Goghs sunflower paintings
11. Genetic mutation depicted in van Goghs sunflower paintings revealed by scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2016)... 2, 2016   The Weather Company , an IBM ... an industry-first capability in which consumers will be able to ... ask questions via voice or text and receive relevant information ... Marketers have long sought an advertising solution that ... be personal, relevant and valuable; and can scale across millions ...
(Date:5/20/2016)... May 20, 2016  VoiceIt is excited to ... VoicePass. By working together, VoiceIt and ... VoiceIt and VoicePass take slightly different approaches to ... both security and usability. ... this new partnership. "This marketing and ...
(Date:5/3/2016)... VILNIUS, Lithuania , May 3, 2016 /PRNewswire/ ... today released the MegaMatcher Automated Biometric Identification ... deployment of large-scale multi-biometric projects. MegaMatcher ABIS can ... and accuracy using any combination of fingerprint, face ... of MegaMatcher SDK and MegaMatcher ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... TORONTO , June 23, 2016 /PRNewswire/ - ... Ontario biotechnology company, Propellon ... the development and commercialization of a portfolio of ... cancers. Epigenetic targets such as WDR5 represent an ... contribute significantly in precision medicine for cancer patients. ...
(Date:6/23/2016)...  The Biodesign Challenge (BDC), a university competition that ... living systems and biotechnology, announced its winning teams at ... New York City . The teams, ... at MoMA,s Celeste Bartos Theater during the daylong summit. ... curator of architecture and design, and Suzanne Lee ...
(Date:6/23/2016)... 23, 2016 Apellis Pharmaceuticals, Inc. today ... trials of its complement C3 inhibitor, APL-2. The ... ascending dose studies designed to assess the safety, ... injection in healthy adult volunteers. Forty ... a single dose (ranging from 45 to 1,440mg) ...
(Date:6/23/2016)... Pleasant Prairie, WI (PRWEB) , ... June 23, ... ... sciences consultancy focused on quality, regulatory and technical consulting, provides a free ... webinar is presented on July 13, 2016 at 12pm CT at no charge. ...
Breaking Biology Technology: