Navigation Links
Scientists report major advance in human antibody therapy against deadly Hendra virus
Date:10/19/2011

Broder, Ph.D., Professor of Microbiology at USU and study corresponding author.

Earlier work at USU and NCI, supported by NIAID conducted under the direction of Dr. Broder and study co-author Dimiter S. Dimitrov, Ph.D., Sc.D., senior investigator at NCI, resulted in the discovery and development of a human monoclonal antibody, m102.4, in work carried out by Zhongyu Zhu, Ph.D. The m102.4 antibody attacks a critical component of Hendra virus and Nipah viruses and prevents their infection of cells. Antibodies proteins found in blood or other bodily fluids of vertebrates are used by the immune system to identify and neutralize viruses and bacteria.

According to study co-author Thomas W. Geisbert, Ph.D., professor in the Department of Microbiology and Immunology at UTMB and the GNL, "We now have good evidence that this antibody could save human lives. The success of the antibody therapy against Hendra virus disease in a nonhuman primate model is a major step forward in developing it for future therapeutic use in people."

Previous work by study coauthor Barry Rockx, Ph.D., formerly of the Laboratory of Virology at the RML and now assistant professor in the Department of Pathology at UTMB, described the Hendra virus nonhuman primate model used in this study which now demonstrates that the m102.4 antibody given as late as three days following infection by Hendra virus, could still save the animals from lethal disease. Major support for the current study came from NIAID, NIH, including grant U01-AI082121 awarded to Dr. Geisbert.

Katharine Bossart, Ph.D., a USU alumna, now an assistant professor in the Department of Microbiology, Boston University School of Medicine, led a collaborative study in Australia that provided the first evidence of the antibody's effectiveness in preventing Nipah virus mediated disease in an animal model.

"This new evidence that m102.4 is highly effective against Hendra virus in a second animal model provi
'/>"/>

Contact: JoAnn Sperber
jsperber@hjf.org
240-694-2163
Henry M. Jackson Foundation for the Advancement of Military Medicine
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Magnifying research: Scientists team together to upgrade supercomputer
2. Scientists first to characterize barley plant-stem rust spore communication
3. Scientists discover dietary moisture window that boosts urinary tract health in cats
4. Southampton scientists herald significant breakthrough in study of chlamydia
5. Scientists move closer to predicting who will and will not fight off severe infections
6. Tagging tumors with gold: Scientists use gold nanorods to flag brain tumors
7. Uncharted territory: Scientists sequence the first carbohydrate biopolymer
8. New drug target for Alzheimers, stroke is discovered by University at Buffalo scientists
9. Scientists discover 3 new gene faults which could increase melanoma risk by 30 percent
10. Scientists identify microbes responsible for consuming natural gas in Deepwater Horizon spill
11. University of Texas marine scientists awarded $5.6 million for study of critical Arctic environment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... in many serious conditions such as heart disease, epilepsy ... drug therapies. Unfortunately, there is still much scientists do ... fresh and unexpected insight into the structure of sodium ... molecules - which are responsible for ,fine-tuning, the activity ... most recent edition of the Journal of Biological ...
(Date:4/17/2014)... have detected new early-warning signs of the potential loss ... far-reaching implications for the diagnosis and treatment of diabetic ... Americans. , "We had not expected to see such ... said Ann Elsner, professor and associate dean in the ... study. "We set out to study the early signs, ...
(Date:4/17/2014)... forests are chock full of wild animals and plant ... of fungi are churning away in the soil, decomposing ... Despite the vital role these fungi play in ecological ... Stanford-led team of scientists has generated a genetic map ... America. The work was published this week in the ...
Breaking Biology News(10 mins):Structure of sodium channels different than previously believed 2New technique detects microscopic diabetes-related eye damage 2New technique detects microscopic diabetes-related eye damage 3Stanford biologists help solve fungal mysteries 2Stanford biologists help solve fungal mysteries 3
... deepest oceans of the world would appear to be shark ... team of researchers, led by the University of Aberdeen, reveal ... 3,000 metres. , Sharks occur throughout the world's oceans and ... the abyss and beyond throughout the largest environment on the ...
... The study was conducted by researchers from Scripps Research; ... National Taiwan University. It is being published today in ... , Chi-Huey Wong is currently the Ernest W. Hahn ... Biology and directs the Scripps Research lab heading the ...
... have assembled a new picture of a 35-million-year-old fossil ... of sound. , By painstakingly measuring hundreds of specimens ... famous fossil beds of Egypt's Fayum Province, the researchers ... only males -- had oversized, swollen lower jaws shaped ...
Cached Biology News:Oceans are 70 percent shark free 2Enzyme inhibitors block replication of SARS virus 2'Banana-jawed' fossil mammal linked to rare sound-producing skill 2'Banana-jawed' fossil mammal linked to rare sound-producing skill 3'Banana-jawed' fossil mammal linked to rare sound-producing skill 4
(Date:1/15/2014)... 15, 2014  Bill Jacobs Automotive, a group of car dealerships ... with the Heartland Blood Center and offering free oil change ... takes place Saturday, Jan. 18 at the Bill Jacobs Cadillac ... (Photo: http://photos.prnewswire.com/prnh/20140115/MN46637 )  The Bill ...
(Date:1/15/2014)... IL (PRWEB) January 15, 2014 Look ... find hard-working items for the lab, from fluid handling ... Guaranteed-in-Stock (GIS)—ready to ship when you order. , ... Peristaltic Pumps , from the L/S® model for precise ...
(Date:1/15/2014)... MINNEAPOLIS , Jan. 15, 2014 ­ RedBrick ... and behavior change technology, today announces that EmblemHealth ... insurer and wellness company, is now providing the RedBrick ... digital coaching program, to all of its members. EmblemHealth ...
(Date:1/15/2014)... 2014 More than 5 million Americans ... in 3 seniors will die with Alzheimer’s or another ... figures have shocked many Americans into looking for ways ... these tragic age-related cognitive disorders. Jonathan Weisman, president of ...
Breaking Biology Technology:Join the Bill Jacobs Auto blood drive and receive a free oil change 2Cole-Parmer Begins 2014 with the Release of Preferred Solutions 2EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 2EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 3Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2
... May 18, 2011 Biomerix Corporation and Cellon today ... 3D Scaffold , a novel three-dimensional tissue scaffold. Under ... 3D Scaffold to research institutions across Europe. ... polyurethane , the Biomerix 3D Scaffold is designed to ...
... at Paterson Public School No. 5 received a brand ... 200 volunteers from Roche, New Jersey Community Development Corporation ... KaBOOM!. The new playground provides the 1,300-plus students enrolled ... children living in the neighborhood with a safe place ...
... 2011 Ludwig Institute for Cancer Research LTD (LICR) and ... to expand development of Polaris, novel cancer drug, pegylated arginine ... of the amino acid arginine. As part ... potential of ADI-PEG 20 as a cancer therapy and aim ...
Cached Biology Technology:Biomerix Corporation Reaches European Distribution Agreement with Cellon S.A. 2Designed by Kids, Built by Volunteers: Roche, New Jersey Community Development Corporation, and KaBOOM! Build New Playground in Just One Day for Paterson Public School Children 2Designed by Kids, Built by Volunteers: Roche, New Jersey Community Development Corporation, and KaBOOM! Build New Playground in Just One Day for Paterson Public School Children 3Designed by Kids, Built by Volunteers: Roche, New Jersey Community Development Corporation, and KaBOOM! Build New Playground in Just One Day for Paterson Public School Children 4Ludwig Institute for Cancer Research and Polaris Group Form Collaboration to Expand Development of Polaris' Novel Cancer Drug, ADI-PEG 20 2Ludwig Institute for Cancer Research and Polaris Group Form Collaboration to Expand Development of Polaris' Novel Cancer Drug, ADI-PEG 20 3Ludwig Institute for Cancer Research and Polaris Group Form Collaboration to Expand Development of Polaris' Novel Cancer Drug, ADI-PEG 20 4