Navigation Links
Scientists report major advance in human antibody therapy against deadly Hendra virus
Date:10/19/2011

Broder, Ph.D., Professor of Microbiology at USU and study corresponding author.

Earlier work at USU and NCI, supported by NIAID conducted under the direction of Dr. Broder and study co-author Dimiter S. Dimitrov, Ph.D., Sc.D., senior investigator at NCI, resulted in the discovery and development of a human monoclonal antibody, m102.4, in work carried out by Zhongyu Zhu, Ph.D. The m102.4 antibody attacks a critical component of Hendra virus and Nipah viruses and prevents their infection of cells. Antibodies proteins found in blood or other bodily fluids of vertebrates are used by the immune system to identify and neutralize viruses and bacteria.

According to study co-author Thomas W. Geisbert, Ph.D., professor in the Department of Microbiology and Immunology at UTMB and the GNL, "We now have good evidence that this antibody could save human lives. The success of the antibody therapy against Hendra virus disease in a nonhuman primate model is a major step forward in developing it for future therapeutic use in people."

Previous work by study coauthor Barry Rockx, Ph.D., formerly of the Laboratory of Virology at the RML and now assistant professor in the Department of Pathology at UTMB, described the Hendra virus nonhuman primate model used in this study which now demonstrates that the m102.4 antibody given as late as three days following infection by Hendra virus, could still save the animals from lethal disease. Major support for the current study came from NIAID, NIH, including grant U01-AI082121 awarded to Dr. Geisbert.

Katharine Bossart, Ph.D., a USU alumna, now an assistant professor in the Department of Microbiology, Boston University School of Medicine, led a collaborative study in Australia that provided the first evidence of the antibody's effectiveness in preventing Nipah virus mediated disease in an animal model.

"This new evidence that m102.4 is highly effective against Hendra virus in a second animal model provi
'/>"/>

Contact: JoAnn Sperber
jsperber@hjf.org
240-694-2163
Henry M. Jackson Foundation for the Advancement of Military Medicine
Source:Eurekalert

0

GOOD

Page: 1 2 3 4

Related biology news :

1. Magnifying research: Scientists team together to upgrade supercomputer
2. Scientists first to characterize barley plant-stem rust spore communication
3. Scientists discover dietary moisture window that boosts urinary tract health in cats
4. Southampton scientists herald significant breakthrough in study of chlamydia
5. Scientists move closer to predicting who will and will not fight off severe infections
6. Tagging tumors with gold: Scientists use gold nanorods to flag brain tumors
7. Uncharted territory: Scientists sequence the first carbohydrate biopolymer
8. New drug target for Alzheimers, stroke is discovered by University at Buffalo scientists
9. Scientists discover 3 new gene faults which could increase melanoma risk by 30 percent
10. Scientists identify microbes responsible for consuming natural gas in Deepwater Horizon spill
11. University of Texas marine scientists awarded $5.6 million for study of critical Arctic environment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... the natural history museums of the world are billions ... beetles to flowers, mushrooms and grasses, all stacked, stored ... rich and diverse collections could be critical to understanding ... of a growing human footprint if only the ... brought to life with the help of a team ...
(Date:5/23/2013)... and fastest growing open-access publishers, announces the launch ... and Biotechnology . , A broad scope ... and Biotechnology will provide a single open-access ... research to be disseminated and discussed. , ... provide an open-science and interactive web platform for ...
(Date:5/23/2013)... Neuron , the team reveal the interplay of brain ... by the Wellcome Trust and BBSRC. , By ... improve our perceptual abilities. While these changes can affect ... affect the fidelity of that response. , ... "When you communicate with others, you can make yourself ...
Breaking Biology News(10 mins):CU-Boulder helps tap crowds to digitize museum records of bugs and plants 2CU-Boulder helps tap crowds to digitize museum records of bugs and plants 3CU-Boulder helps tap crowds to digitize museum records of bugs and plants 4Frontiers launches new open-access journal in Bioengineering and Biotechnology 2
... Spanish . The search is on for ... a biologically based approach to controlling silverleaf nightshade, an invasive ... Africa, India, Australia and elsewhere. According to U.S. ... Solanum elaeagnifolium , is being targeted for its ability ...
... (Nov. 24, 2010) -- The bacterial cell is ... compartment with limited internal structure, a primitive cell cycle, ... a new book, Cell Biology of Bacteria , ... distinct intracellular compartments that help orchestrate complex biochemical processes. ...
... Ill. The long, anxious wait for biopsy results ... developed at the University of Illinois. The research ... vibrational imaging (NIVI), on rat breast-cancer cells and tissues. ... tumor boundaries, with more than 99 percent confidence ...
Cached Biology News:Overseas lab seeks US weed control 'recruits' 2New imaging technique accurately finds cancer cells, fast 2New imaging technique accurately finds cancer cells, fast 3
(Date:5/23/2013)... May 23, 2013 African ... tracing for people of African descent, today announced ... offering. For people of all races, myDNAmix determines ... five distinct populations: Indigenous Americas (Native American), East ... Subcontinent. , Originally launched in late ...
(Date:5/23/2013)... Missouri (PRWEB) May 23, 2013 ... manufacture of complete thermal systems, recently introduced its ... 90 years of experience in designing and manufacturing ... selection of products to serve diverse customer needs. ... is featured at the beginning of the book. ...
(Date:5/22/2013)... Oven Industries announces the new 5R1-1400 AC ... a PC through the TTL level UART Communication port. ... square can deliver up to 15 AMPS of load ... state relay. Operator safety is achieved with 1KV of ... sensor input. Specifications: Input Voltage 85 to 265VAC ...
(Date:5/22/2013)... MA (PRWEB) May 22, 2013 Cambridge ... present at last week’s “Data Demonstration Day” on Capitol Hill, ... Semantics joined EMC, Google, Microsoft and others to showcase how ... proposed Digital Accountability and Transparency Act (DATA Act). , Originally ... Issa (R-CA) and Sen. Mark Warner ...
Breaking Biology Technology:AfricanAncestry.com Rolls Out Improved MyDNAMix Admixture Test for People of all Races; Enhancements Increase Accuracy in Estimation of Ancestral Makeup 2AfricanAncestry.com Rolls Out Improved MyDNAMix Admixture Test for People of all Races; Enhancements Increase Accuracy in Estimation of Ancestral Makeup 3Watlow Introduces Its New Industrial Heater Catalog 2New AC Temperature Controller Announced by Oven Industries 2Cambridge Semantics Underscores Need for Smart Data during “Data Demonstration Day” on Capitol Hill 2
... Year, East Coast,s Largest Independent Clinical Lab Services ... ... KNOLLS, N.J., Feb. 14 MedeFile,International, Inc. (OTC Bulletin ... management solutions, today announced,that it has signed a collaborative ...
... Department of Veterans Services Partners with New Mexico Tech ... ... The New Mexico,Institute of Mining and Technology (New Mexico Tech) and ... the New Mexico,Department of Veterans Services (DVS) to conduct a $350,000 ...
... 14 BioSpace, the world,s leading,niche online ... the,expansion of its reach to local regional ... parent company, onTargetjobs. With the,inclusion of RegionalHelpWanted.com,s ... boards, BioSpace now offers biotechnology,pharmaceutical, medical device ...
Cached Biology Technology:Hayes Clinical Labs to Market MedeFile's Proprietary Electronic Medical Record Management Solution to Patients 2Hayes Clinical Labs to Market MedeFile's Proprietary Electronic Medical Record Management Solution to Patients 3Hayes Clinical Labs to Market MedeFile's Proprietary Electronic Medical Record Management Solution to Patients 4New Technology for Early Detection of Lung Cancer Selected for Clinical Study With Veterans 2BioSpace.com Strengthens Local Market Candidate Reach Through RegionalHelpWanted.com Acquisition 2BioSpace.com Strengthens Local Market Candidate Reach Through RegionalHelpWanted.com Acquisition 3
Mature rat whole blood (Sprague-Dawley, averaging 7-8 weeks of age, either sex) is collected at the time of slaughter and processed within 45 minutes. It is then filtered through gauze, pooled in an ...
LAL Chromogenic Endpoint assay...
uncoupling protein 2 (mitochondrial, proton carrier), mRNA (cDNA clone MGC:19567 IMAGE:4335185), complete cds...
Standard 2" or 3" Plastic can be ordered with 81 or 100 cell dividers. Mini 2" Plastics Boxes come standard with 25 cell dividers. Plastic boxes can also be ordered with corresponding freezer racks...
Biology Products: