Navigation Links
Scientists reengineer antibiotic to overcome dangerous antibiotic-resistant bacteria
Date:8/24/2011

ed to a nitrogen, N) instead of an amide at a key position buried in the interior of the natural product. However, to install such a functional group, the chemical properties of the amide carbonyl were not useful, as the natural product has seven of them.

Instead, the group relied on the chemical properties of sulfur (S), oxygen's downstairs neighbor in the periodic table, to install the desired nitrogen. To do this, a second analogue was prepared in which the key amide was chemically altered to a thioamide. "The thioamide allowed us to make any modification at the residue 4 amide that we would like to make, such as the amidine, but we could also make the methylene analogue," said Boger citing work published in another paper (B. Crowley and D. L. Boger, J. Am. Chem. Soc. 128: 2885-2892). "And there are other modifications that we are making at the present time that we haven't disclosed. We are just getting to that work."

The most fundamental finding in the synthesis was that the installation of the amidine could be done in the last step, as a single-step conversion, on the fully unprotected thioamide analogue. Providing an elegant and novel approach to the analogue, which contrasts other published multistep procedures. This chemical behavior was, as Boger said, "an astonishing result as there are no protecting groups and it is a single step reaction in the end it was the simplest and most straightforward way to prepare the amidine."

Although it is still at its early stages and there is much work ahead. Currently, the only route known to make the new antibiotic is the one published by Boger and his co-workers, which presently provides laboratory amounts of the compound. So Professor Boger now looks forward and will continue to investigate the "host of alternative approaches" for the preparation of the molecule "such as reengineered organisms to produce the material or semi-synthetic approaches to the analogue. That is going to be part of t
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
2. Scientists identify novel inhibitor of human microRNA
3. Argonne scientists peer into heart of compound that may detect chemical, biological weapons
4. MU scientists go green with gold, distribute environmentally friendly nanoparticles
5. Scientists identify gene that may contribute to improved rice yield
6. Scientists discover why a mothers high-fat diet contributes to obesity in her children
7. MU scientists see how HIV matures into an infection
8. Earth scientists keep an eye on Texas
9. Thinking it through: Scientists call for policy to guide biofuels industry toward sustainability
10. Scientists identify a molecule that coordinates the movement of cells
11. Scientists Find new migratory patterns for Mediterranean and Western Atlantic bluefin tuna
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists reengineer antibiotic to overcome dangerous antibiotic-resistant bacteria
(Date:8/19/2014)... Eos: Long-Term Ecological Research and Network-Level Science, , Imagine ... wide range of ecosystems was responding to global changes ... powerful if it coupled multiple decades of information about ... and models from dozens of different ecosystem types. ... Long-Term Ecological Research (LTER) Network, which will soon celebrate ...
(Date:8/19/2014)... a biomarker strongly associated with basal-like breast cancer, ... many types of chemotherapy. The biomarker, a protein ... therapeutics designed to treat this often deadly cancer. ... The Cancer Genome Atlas, molecular biologists Curt M. ... and bioinformatics techniques to detect patterns of gene ...
(Date:8/19/2014)... Texas Health Science Center at San Antonio and The ... the awarding of more than $750,000 in grants through ... , Launched in 2003, SALSI is a model of ... health science center join forces for greater research and ... with a focus on public health issues and diseases ...
Breaking Biology News(10 mins):This week from AGU: Long-term ecological research, predicting cholera outbreaks 2Biomarker in an aggressive breast cancer is identified 2Biomarker in an aggressive breast cancer is identified 3San Antonio Life Sciences Institute awards $750,000 to innovators 2San Antonio Life Sciences Institute awards $750,000 to innovators 3
... greater role in the disparity between the numbers of ... with the disease. A study by researchers at the ... the disparity was substantially reduced when comparing groups of ... environments. The results are published in the November 2008 ...
... RELEASE LEDs ... Chemical Society Researchers in Germany are describing a ... facial wrinkles. Their study, scheduled for the November 5 ... a bi-monthly journal, reports that high intensity visible light ...
... amyloid-b (Ab), builds up into fibrous plaques in the ... membrane microdomain to another to be cleaved, report Sakurai ... that Ab plaques are the direct cause of Alzheimer,s ... And working on this hypothesis, scientists are investigating just ...
Cached Biology News:Hypertension disparity linked to environment 2American Chemical Society Weekly PressPac Oct. 15, 2008 2American Chemical Society Weekly PressPac Oct. 15, 2008 3American Chemical Society Weekly PressPac Oct. 15, 2008 4American Chemical Society Weekly PressPac Oct. 15, 2008 5American Chemical Society Weekly PressPac Oct. 15, 2008 6American Chemical Society Weekly PressPac Oct. 15, 2008 7American Chemical Society Weekly PressPac Oct. 15, 2008 8
(Date:8/18/2014)... -- TNI BioTech, Inc. (OTC-BB: TNIB) ("we" or the ... of innovative therapies for autoimmune diseases in emerging nations, ... notice of TNI BioTech,s annual meeting of September 4, ... Griffin , founder and CEO of TNI BioTech Inc. ... the Annual Meeting. On behalf of our employees and ...
(Date:8/18/2014)... 2014 China is increasingly being ... clinical research industry. Clinicaltrial.gov statistics highlight the popularity ... aging population; a high increase in infectious diseases; ... populated pool of patients and a track record ... points, China also presents challenges for the clinical ...
(Date:8/16/2014)... York, NY (PRWEB) August 16, 2014 ... Consulting industry provide guidance and advisory services ... scientific and technical issues. Industry services are highly ... markets. Therefore, industry services range from geological and ... expansion plans. “Consequently, over the past five years, ...
(Date:8/16/2014)... have found a way to make atomic-force microscope probes ... as small as the weight of an individual virus. ... National University (ANU), hinges on using laser beams to ... , "The level of sensitivity achieved after cooling is ... a large virus that is 100 billion times lighter ...
Breaking Biology Technology:TNI BioTech Inc., provides 2nd Notice of Annual Meeting September 4, 2014 2TNI BioTech Inc., provides 2nd Notice of Annual Meeting September 4, 2014 3TNI BioTech Inc., provides 2nd Notice of Annual Meeting September 4, 2014 4China – Land of Opportunities & Challenges for the Clinical Research Industry, New Webinar Hosted by Xtalks 2Scientific and Economic Consulting in Canada Industry Market Research Report Now Available from IBISWorld 2Scientific and Economic Consulting in Canada Industry Market Research Report Now Available from IBISWorld 3Laser makes microscopes way cooler 2
... 31 /PRNewswire-FirstCall/ - iNutrition, Inc., (http://www.inutrition.com ) today ... all natural line of nutrition bars. Fission Fruit ... in three varieties; Fission Fruit, Fission,Energy, and Fission ... fruits, Fission Bars have no refined sugar, no ...
... Ala., July 31 BioCryst,Pharmaceuticals (Nasdaq: BCRX ... results will be released on Thursday, August 7, ... call and Webcast at 8:30 a.m.,Eastern Time to ... on the,Company,s programs. The call will be led ...
... 31 Genta,Incorporated (OTC Bulletin Board: GNTA) announced ... 2008 financial results on Thursday, August,7, 2008. Genta ... audio,webcast to discuss these financial results and corporate ... the live call by dialing (877) 634-8606 (U.S.,and ...
Cached Biology Technology:iNutrition Launches New Fission Fruit Nutrition Bars 2BioCryst Pharmaceuticals To Announce Second Quarter 2008 Financial Results on August 7, 2008 2BioCryst Pharmaceuticals To Announce Second Quarter 2008 Financial Results on August 7, 2008 3Genta Announces Second Quarter 2008 Financial Results and Conference Call 2Genta Announces Second Quarter 2008 Financial Results and Conference Call 3
Rabbit Anti-Human Secretory Carrier Membrane Protein 2 (SCAMP2 Polyclonal AntibodyOther Sub-Family: not assigned-Other Applications: Western Blot...
Parathyroid Hormone Receptor 2 [PTHR2]...
... Spin Columns contain a proprietary high-performance desalting ... desalting and protein-recovery characteristics compared to other ... as 25 g/ml of protein can be ... 95% retention of salts and other small ...
... caudal-related homeobox family, is an intestine-specific transcription ... in intestinal epithelial cells. It plays an ... phenotype of differentiated villus enterocytes as well ... Clone CDX2-88 reacts with a conserved epitope ...
Biology Products: