Navigation Links
Scientists post lower speed limit for cell-signaling protein assembly
Date:7/29/2010

or proteins as they spontaneously assemble into their lowest-energy, so-called natural state like a relaxed spring.

"In order to measure how quickly this random, unfolded state changes confirmations, we had to design an entirely new apparatus as well as design and fabricate a microfluidic chip capable of observing proteins within a fraction of a millisecond after being allowed to refold," Waldauer explained. Two lasers were employed to observe the formation of the immunoglobulin proteins.

"We found that the nature of the unfolded state is far from intuitive and that a protein will change from one random conformation to another much more slowly than previously thought," he said.

Scientists know that errors can occur in folding, and these are associated with a variety of diseases including Alzheimer's, ALS, cystic fibrosis and diabetes. Lapidus and colleagues speculate that the rate of the process could influence the outcome. Proteins that wiggle more rapidly, for example, may be more prone to sticking together and causing plaques such as those in Alzheimer's. The team's discovery may lead to new therapeutic strategies for this class of diseases.

"I believe this measurement of intramolecular diffusion is something that will be crucial for any subsequent studies of protein folding or mis-folding," Lapidus said.


'/>"/>

Contact: Mark Fellows
mark.fellows@ur.msu.edu
517-884-0166
Michigan State University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
2. Scientists identify novel inhibitor of human microRNA
3. Argonne scientists peer into heart of compound that may detect chemical, biological weapons
4. MU scientists go green with gold, distribute environmentally friendly nanoparticles
5. Scientists identify gene that may contribute to improved rice yield
6. Scientists discover why a mothers high-fat diet contributes to obesity in her children
7. MU scientists see how HIV matures into an infection
8. Earth scientists keep an eye on Texas
9. Thinking it through: Scientists call for policy to guide biofuels industry toward sustainability
10. Scientists identify a molecule that coordinates the movement of cells
11. Scientists Find new migratory patterns for Mediterranean and Western Atlantic bluefin tuna
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists post lower speed limit for cell-signaling protein assembly
(Date:11/21/2014)... , Nov. 20, 2014 Strict laws against ... are piloting the North American and European automotive sector ... growing, gesture recognition systems that are intuitive and able ... in the industry. New analysis from ... Recognition Market in Europe and ...
(Date:11/21/2014)... , Nov. 20, 2014   Atmel® Corporation ... microcontroller (MCU) and touch technology solutions, today launched the ... with the widest V cc range from ... accuracy and faster I 2 C bus communication speeds, ... EEPROM memory making them ideal for consumer, industrial, computer, ...
(Date:11/18/2014)... 17, 2014   News Highlights: ... to develop The Partners Data Lake, an agile ... Data Lake will allow researcher and clinicians to ... and the lives of patients , The ... activities across the Partners system, breaking down physical ...
Breaking Biology News(10 mins):Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5
... in the soil can transform the most commonly used flame ... that could be harmful to humans, according to a new ... American Chemical Society journal, Environmental Science & Technology . ... print issue of the journal. , The finding, by a ...
... George's, University of London, are developing drugs designed to ... harmless. , Professor David Garrod said the research ?recently ... of the Year ?takes a completely new approach to ... is based on our earlier discovery of how allergens, ...
... Research by Warwick Medical School at the University of ... an almost a two-fold increased risk of being obese ... a study by Professor Francesco Cappuccio of the University ... International AC21 Research Festival hosted this month by the ...
Cached Biology News:Microbes transform 'safest' PBDEs into more harmful compounds 2Allergy battle could be won in five years, says scientist 2Sleep deprivation doubles risks of obesity in both children and adults 2
(Date:12/22/2014)... December 22, 2014 Fertility Associates of ... Egg Bank USA , a network of more than ... this partnership, patients have fast access to a national ... fertilization, IVF . Fertility Associates of Memphis is the ... fertility treatment option. , Dr. William Kutteh , ...
(Date:12/19/2014)... Charm Sciences is pleased to announce ... of Aflatoxin M1 in raw commingled milk is the ... validation. The peer reviewed report of the validation by ... Agricultural and Fisheries Research (ILVO-T&V) has been published by ... the most toxic aflatoxin and a known carcinogen, can ...
(Date:12/19/2014)... -- Naurex Inc., a biopharmaceutical company leveraging its unique ... central nervous system, today announced that Norbert Riedel ... at the 33 rd annual J.P. Morgan Healthcare ... p.m. PST on Tuesday, January 13, 2015, at the ... About Naurex Inc. ...
(Date:12/19/2014)... , Dec. 19, 2014 Bina Technologies, Inc. ... announced today that they have been acquired by Roche ... is a privately held company that provides a big ... generation sequencing (NGS) data for the academic and translational ... Sequencing Unit, and will continue to focus on development ...
Breaking Biology Technology:Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3Charm Sciences Achieves Independent Validation of First 15 Minute Quantitative Screening Method for Aflatoxin M1 2Naurex to Present at 33rd Annual J.P. Morgan Healthcare Conference 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... Pa., May 5 Cadient Interactive ... specializing in custom-created digital campaigns, tools and services, today ... award-winning creative team appointing Bethany (Beth) Hartzell to associate ... of creative experts and digital thought leaders to provide ...
... Syrinx Consulting Corporation , an ... .Net and SharePoint applications , announced ... $100,000 with a leading biopharmaceutical company in the Boston ... users and gigabytes of data from a SharePoint 2003 ...
... of Rheumatology Examines Quality of Life and Disability ... 5 Savient Pharmaceuticals, Inc. (Nasdaq: ... the Savient-supported longitudinal observational (non-interventional) study of patients ... the study was to determine the baseline characteristics ...
Cached Biology Technology:Cadient Interactive Expands Creative Leadership with New Associate Director 2Syrinx Wins Contract with Leading Pharmaceutical Company for SharePoint 2007 Services 2Disability and Poor Quality of Life Associated With Treatment Failure Gout Patients 2Disability and Poor Quality of Life Associated With Treatment Failure Gout Patients 3Disability and Poor Quality of Life Associated With Treatment Failure Gout Patients 4
... of Printing Surface (3 glass slides coated with 100 ... silicon wafer coated with 1000 Angstroms of Gold over ... Stamps (3 PDMS micropatterned stamps with series of 100 ... mm or 200 um x 10 mm lines, 3 ...
Melanoma Antigen, Family C, 1 (MAGEC1) Rabbit anti-Human Polyclonal Antibody Immunogen: Synthetic peptide - KLH conjugated Family: New Recommended Storage: Long term: -20C; Short term: +4...
...
ECE-1 (H-60)...
Biology Products: