Navigation Links
Scientists post lower speed limit for cell-signaling protein assembly
Date:7/29/2010

EAST LANSING, Mich. The apparently random self-assembly of molecular threads into the proteins that make the body work is far less frantic than previously thought, Michigan State University scientists say. That discovery could be a key to help unlock the nature of some diseases.

How proteins spontaneously "fold" from wiggling chains of amino acids into a wide variety of functional or malfunctioning three-dimensional molecules is one of the biggest mysteries in biochemistry.

"People thought they understood how protein diffusion worked, but now our data suggests they're wrong by a factor of 1,000," MSU physics and astronomy assistant professor Lisa Lapidus said. "Now we can start changing the models we've been trying to solve protein folding for 50 years, and now we're advancing our fundamental understanding of what unfolded proteins do before they fold."

The findings were published online by the science journal Proceedings of the National Academy of Sciences. Lapidus was joined in the research by University of Zurich Institute of Physical Chemistry researcher Steven Waldauer, whose recent MSU doctoral dissertation formed the basis of the study, and University of California, Davis, scientist Olgica Bakajin.

Proteins, which do most of the work in the body's cells, are chain molecules composed of amino acids. The order in which the amino acids are assembled was charted by the Human Genome Project, but the function of the protein depends on its shape, and how a protein folds is not yet understood. Much of the process is random and diffusive, like sugar moving through an unstirred cup of coffee.

Most proteins can fold in milliseconds, although there are so many possible combinations that left to chance it's physically impossible, scientists agree. So they speculate that there must be built-in folding pathways but those remain unproved. Now physics is helping make sense of biology, posting a lower speed limit f
'/>"/>

Contact: Mark Fellows
mark.fellows@ur.msu.edu
517-884-0166
Michigan State University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
2. Scientists identify novel inhibitor of human microRNA
3. Argonne scientists peer into heart of compound that may detect chemical, biological weapons
4. MU scientists go green with gold, distribute environmentally friendly nanoparticles
5. Scientists identify gene that may contribute to improved rice yield
6. Scientists discover why a mothers high-fat diet contributes to obesity in her children
7. MU scientists see how HIV matures into an infection
8. Earth scientists keep an eye on Texas
9. Thinking it through: Scientists call for policy to guide biofuels industry toward sustainability
10. Scientists identify a molecule that coordinates the movement of cells
11. Scientists Find new migratory patterns for Mediterranean and Western Atlantic bluefin tuna
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists post lower speed limit for cell-signaling protein assembly
(Date:3/12/2015)... 12, 2015 Beta Systems ... and access management (IAM) solution for a fixed ... Beta System,s new IAM package, customers benefit from ... from multiple IAM implementations across different industries. The ... well as any necessary services and consulting. It ...
(Date:3/10/2015)... Colo. , March 10, 2015 ... Flight "Personalized Medicine in Human Space ... and Thomas J. Goodwin , Ph.D. was recently ... of the past two years. Specifically, "Personalized ... most downloaded scientific papers published in 2013 and 2014 ...
(Date:3/3/2015)... FOREST, Calif. , March 3, 2015 ... the leading provider of advanced cryogenic logistics ... markets including immunotherapies, stem cells, cell lines, ... and reproductive medicine, today announced the expansion ... Cancer Research Centers, ("Fred Hutch") Clinical ...
Breaking Biology News(10 mins):Beta Systems Fast Forward IAM Available Now: a Standardized IAM Package at a Fixed Price 2"Personalized Medicine in Human Space Flight" Listed Among Most Influential Papers of 2013 and 2014 2Cryoport, Inc. Expands Support of Fred Hutchinson Cancer Research Center's Clinical Research Division 2Cryoport, Inc. Expands Support of Fred Hutchinson Cancer Research Center's Clinical Research Division 3
... is emerging for how important it is for pregnant women ... every day seem to have children who are less likely ... study from the Sahlgrenska Academy at the University of ... with Linkping University, which is conducting a population study called ...
... awarded $6.27 million to develop an interactive software system ... home. The funding, which covers a two-year period, includes ... Projects Agency-Energy (ARPA-E), About $1.28 million in matching grants ... Energy Commission. The Stanford team will focus on ...
... Origin of Species 150 years ago, he deliberately avoided the ... mention of the ,Creator, in the last paragraph of the ... commit on the matter. An international team, led by Juli ... idea and shows that the British naturalist did explain in ...
Cached Biology News:Vegetables can protect unborn child against diabetes 2Stanford researchers awarded $6.27 million to study energy efficiency and human behavior 2Charles Darwin really did have advanced ideas about the origin of life 2
(Date:4/1/2015)... NJ (PRWEB) April 01, 2015 Earlier ... BioNJ, a vibrant life sciences industry association that represents ... 400 members. , Jonathan Parker, AJO’s Vice President ... Gala Dinner in February, an event that attracted over ... highlights, Don Wright, a 73 year old cancer survivor ...
(Date:3/31/2015)... 2015 CytoSorbents Corporation (NASDAQ CM: CTSO), ... to treat critically-ill and cardiac surgery patients in ... reports financial results for the fiscal year ending ... product revenues were a record $3.1M, an increase ... revenues of $0.8M Highlights for the Year Ending ...
(Date:3/31/2015)... Richmond, KY (PRWEB) March 31, 2015 ... top 50 schools for online bachelor’s of criminal ... committed to connecting people to inspiring ideas and ... in an e-mail to the University. We are ... Kentucky University.” , This is the site’s ...
(Date:3/31/2015)... , March 31, 2015  Sonoa Health, a health ... , has developed a world-first consumer health portal, Health&, ... prescriptions, wearable devices and more. Today, the ... as its CEO, who brings to the table more ... which has included working closely with the biggest names ...
Breaking Biology Technology:HR Consulting Firm, A.J. O'Connor Associates Joins BioNJ – The Vibrant 400 Member Strong Life Sciences Industry Association - and Attends its Annual Dinner 2CytoSorbents Reports Record 2014 Revenue 2CytoSorbents Reports Record 2014 Revenue 3CytoSorbents Reports Record 2014 Revenue 4CytoSorbents Reports Record 2014 Revenue 5CytoSorbents Reports Record 2014 Revenue 6CytoSorbents Reports Record 2014 Revenue 7CytoSorbents Reports Record 2014 Revenue 8CytoSorbents Reports Record 2014 Revenue 9CytoSorbents Reports Record 2014 Revenue 10CytoSorbents Reports Record 2014 Revenue 11EKU Ranked in Top 50 Among Online Criminal Justice Degrees 2Investment Banker Appointed CEO of Australian Health Tech Start-Up 2Investment Banker Appointed CEO of Australian Health Tech Start-Up 3
... Technology, Inc. announced today that Jim Bullock has been ... company.  Before joining Zyga Technology, Jim was President and ... Boston Scientific.  Prior to Atritech, Jim was President and ... St. Jude Medical.  (Logo: http://photos.prnewswire.com/prnh/20110118/CG30384LOGO ...
... BEIJING, January 16, 2012 Elsevier, ... information products and services, announced today that its ... management, NursingChina , is now available online. ... online reference product available in China, featuring skills ...
... in a wide variety of applications from food ... applications. Thermal analysis is routinely used to analyze ... to use nanostructured materials has made bulk techniques ... force microscope-based technique called nanoscale thermal analysis (nanoTA) ...
Cached Biology Technology:Zyga Technology, Inc. Announces the Appointment of Jim Bullock as President and CEO 2Elsevier Launches Bilingual International Nursing Skill Training and Management Platform: NursingChina.com 2Elsevier Launches Bilingual International Nursing Skill Training and Management Platform: NursingChina.com 3Magnetic actuation enables nanoscale thermal analysis 2
... Hypothetical protein FLJ20644, likely ortholog of ... Protein Accession #: NP_060387.1 gi ... Definition: chromosome 14 open reading frame ... gene g4-1 [Homo sapiens] Locus ...
1/4" to 1/8" Adapter for Reflectance Probe Holder...
ACAT-1 (H-125)...
Mouse monoclonal [B314.1 (MAC 387)] to Macrophage L1 protein Calprotectin (rating: ****) ( Abpromise for all tested applications)....
Biology Products: