Navigation Links
Scientists pinpoint molecular signals that make some women prone to miscarriage
Date:1/3/2013

The research, carried out at Imperial College London and the University of Warwick, suggests these signals could be targets for drugs that would help prevent miscarriage in women who are particularly vulnerable.

At the start of pregnancy, the fertilised embryo must embed itself in the lining of the uterus. The uterus is only receptive to embryos for a few days in each menstrual cycle, ensuring that embryos can only implant at the right stage of development. Currently scientists know only a few details about the biological processes that control when an embryo can be implanted.

In the latest study, published in the journal PLOS ONE, researchers studied chemical signals produced by human cells, taken from the lining of the uterus and grown in the lab. They identified a key role for a molecule called IL-33, which the cells secrete during the receptive phase and which influences the activity of nearby cells.

Normally, the effects of IL-33 and other chemical signals in the lining of the womb are short-lived, which helps to ensure that woman can only conceive during a narrow window. In cells from women who had suffered three or more miscarriages however, high levels of IL-33 continued to be secreted for 10 days, suggesting that the receptivity of the uterus was not being controlled properly in these women.

The study also looked at the effects of these molecular signals on fertility in mice. The researchers treated the uteruses of the mice with chemicals secreted by cells from the human womb lining. They found that chemicals produced by cells from women with repeated miscarriages extended the time during which mice could become pregnant, but also made miscarriages more likely. The researchers conclude that a prolonged window of fertility increases the risk of abnormal embryos implanting. In addition, it is associated with inflammation in the lining of the womb, which compromises the development of healthy embryos.

'/>"/>
Contact: Sam Wong
sam.wong@imperial.ac.uk
Imperial College London
Source:Eurekalert

Page: 1 2

Related biology news :

1. Stanford scientists develop gene therapy approach to grow blood vessels in ischemic limbs
2. Queens scientists seek vaccine for Pseudomonas infection
3. Scientists produce eye structures from human blood-derived stem cells
4. American Society of Plant Biologists honors early career women scientists
5. Brandeis scientists win prestigious prize for circadian rhythms research
6. Scientists discover new method of proton transfer
7. Salk scientists open new window into how cancers override cellular growth controls
8. WileyChina.com - Now Featuring Bespoke Pages for China’s Life Scientists
9. Scientists win $2 million to study new pathway in development and maintenance of lymphoma
10. UGA scientists reveal genetic mutation depicted in van Goghs sunflower paintings
11. Genetic mutation depicted in van Goghs sunflower paintings revealed by scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/8/2015)... , May 8, 2015 Synaptics Inc. (NASDAQ: ... today announced that members of the executive management team will ... 43rd Annual Technology, Media and Telecom Conference Date: May ... in Boston, MA Cowen ... 2015 Time: 2:45pm ET Location: The New York Palace Hotel, ...
(Date:5/5/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... mobile commerce market, reminds investors and media that  Mr. ...  at CARTES SECURE CONNEXIONS AMERICA 2015, held in ... The three-day conference is organized into a series of nine ... Global Fraud: Where is the Trust in Cyberspace? ...
(Date:4/27/2015)... , Apr. 27, 2015 Profile Solutions, ... control and security systems is pleased to announce that ... as a consultant and member of its scientific advisory ... widely known as a thought leader in technology-enhanced learning ... Technology Group, and has published studies and books focused ...
Breaking Biology News(10 mins):Synaptics to Present at Upcoming Investor Conferences 2NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 2NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 2Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 4
... Ill. (June 18, 2012) Seeking to solve some ... source facilities at national research laboratories in the United ... Canadian Light Source and the Advanced Photon Source (APS) ... Laboratory agreed in January 2012 to a Partner User ...
... , PHILADELPHIA Healthy humans harbor an enormous and ... within their intestines. These microbial partners provide beneficial aid ... the development of a healthy immune system. In a ... , David Artis, PhD, associate professor of Microbiology, and ...
... to the simple sponge to find clues about the evolution ... a mechanism that coordinates the expression of genes that lead ... of the animal world may not be so distant after ... network," are published in the Proceedings of the National ...
Cached Biology News:Advanced Photon Source and Canadian Light Source strengthen ties 2Brothers in arms: Commensal bacteria help fight viruses 2Clues to nervous system evolution found in nerve-less sponge 2
(Date:5/28/2015)... May 28, 2015 CD-adapco, the ... Engineering software, announced today it is joining the ... will provide state-of-the-art engineering simulation tools for analyzing ... expertise and experiences in analyzing particle flow that ... and advance the understanding of flow modeling solutions. ...
(Date:5/28/2015)... 2015 Glenn Keet, CEO of ... of EMR/EHR Clinical Data Integration with EDC Systems ” ... Washington, DC on June 14th-18th. , During the presentation, ... systems with EDC, and will examine the value of ... and electronic health records/electronic medical records integration. , ...
(Date:5/28/2015)... May 28, 2015 Global futurist ... point to ask his audiences if they are ... including robotics, solar cells, fuel cells, rapid health ... advanced battery storage technology, driverless cars, artificial intelligence ... but inexpensive online education. , While the ...
(Date:5/28/2015)... 2015 Dr. Carl Peck, MD, ... Roger L. Williams, MD, has joined the firm ... Experts are top tier consultants whose expertise and ... to the company’s clients. Premier Experts collaborate to ... successfully develop their medical products, pursue optimal regulatory ...
Breaking Biology Technology:CD-adapco and PSRI Chartering New Course in Particle Flow Simulations 2Clinovo Presents at the DIA 2015 51st Annual Meeting in Washington, DC on June 14th-18th 2Futurist Jack Uldrich to Deliver 4 Keynote Addresses in June 2Former CEO and Chair of the Council of Experts at the USP, Roger L. Williams, MD, Joins NDA Partners as a Premier Expert Consultant 2
... of... -- CAMBRIDGE, Massachusetts, August 26, 2010 ... ... ... first_result; // Results are keyed by longUrl, so we need to grab the first one. for ...
... New York State Department of Health has licensed Genelex Corporation,s ... state. The issued Clinical Laboratory Permit is for DNA testing ... 50 percent of the most commonly prescribed medicines. Research shows ... the genetic coding for these enzymes, greatly increasing their risk ...
... CFO -- LONDON, August 26, 2010 ... ... var shortURL = ... so we need to grab the first one. for (var r in data.results) { first_result = data.results[r]; ...
Cached Biology Technology:Shire Announces European Approval of VPRIV(R) (velaglucerase alfa) for the Treatment of Type 1 Gaucher Disease 2Shire Announces European Approval of VPRIV(R) (velaglucerase alfa) for the Treatment of Type 1 Gaucher Disease 3Shire Announces European Approval of VPRIV(R) (velaglucerase alfa) for the Treatment of Type 1 Gaucher Disease 4Shire Announces European Approval of VPRIV(R) (velaglucerase alfa) for the Treatment of Type 1 Gaucher Disease 5Shire Announces European Approval of VPRIV(R) (velaglucerase alfa) for the Treatment of Type 1 Gaucher Disease 6Shire Announces European Approval of VPRIV(R) (velaglucerase alfa) for the Treatment of Type 1 Gaucher Disease 7Shire Announces European Approval of VPRIV(R) (velaglucerase alfa) for the Treatment of Type 1 Gaucher Disease 8Shire Announces European Approval of VPRIV(R) (velaglucerase alfa) for the Treatment of Type 1 Gaucher Disease 9New York State Licenses Personalized Prescribing DNA Tests 2Hikma - Half Year Results Interviews With CEO and CFO 2Hikma - Half Year Results Interviews With CEO and CFO 3Hikma - Half Year Results Interviews With CEO and CFO 4Hikma - Half Year Results Interviews With CEO and CFO 5
... syringe pump series combines Harvard Apparatuss best pump ... a wide range of configuration options. A lookup ... of syringes from all the major manufacturers. A ... the pertinent information from across the lab. All ...
... number is a new product number, created ... showing no availability yet, please order under ... customer service for assistance. Feature: ... surface area 21 cm 2 D ...
... microscopy is the ultimate tool for investigating ... Its applications previously have been limited at ... optics do not transmit in the deep ... fluorescence spectroscopy, introduces a filter-based confocal system ...
... using many of the automation concepts from ... requirements are similar to those for HTS: ... 24 or 48 wells with well volumes ... the number of wells has increased to ...
Biology Products: