Navigation Links
Scientists offer way to address 'age-old' questions
Date:9/7/2011

responding to their environment or is the change random?

Kussell and Leibler sought to develop a method that could disentangle these strategies. They showed that individual histories of cellstheir lineageswould reveal differences between stochastic and responsive switching.

"Since stochastic switching organisms rely on selection to survive, we expected that if we could measure the strength of selection, we could distinguish the two strategies," Kussell said. "Once again, selection leaves a key signature in the population's lineage tree. In this case, the signature is the variance in cell divisions between lineages. If we measure that, then we can tell which strategy the cells are using internally."

The researchers simulated bacteria growing under fluctuating environmental conditions, and applied their lineage-based tests. This allowed them to show that the lineage tree indeed contains sufficient information to distinguish the two cellular strategies.

The importance of stochastic switching has recently been demonstrated in populations of cancer cells. With improved lineage tracking tools for cancer cells, it may soon become possible to apply some of the ideas that Kussell and co-workers have been developing in the bacterial context, also in other systems, such as tumor and stem cell populations.


'/>"/>

Contact: James Devitt
james.devitt@nyu.edu
212-998-6808
New York University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
2. Scientists identify novel inhibitor of human microRNA
3. Argonne scientists peer into heart of compound that may detect chemical, biological weapons
4. MU scientists go green with gold, distribute environmentally friendly nanoparticles
5. Scientists identify gene that may contribute to improved rice yield
6. Scientists discover why a mothers high-fat diet contributes to obesity in her children
7. MU scientists see how HIV matures into an infection
8. Earth scientists keep an eye on Texas
9. Thinking it through: Scientists call for policy to guide biofuels industry toward sustainability
10. Scientists identify a molecule that coordinates the movement of cells
11. Scientists Find new migratory patterns for Mediterranean and Western Atlantic bluefin tuna
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2014)... have identified a biomarker strongly associated with basal-like ... resistant to many types of chemotherapy. The biomarker, ... for new therapeutics designed to treat this often ... taken from The Cancer Genome Atlas, molecular biologists ... powerful computational and bioinformatics techniques to detect patterns ...
(Date:8/19/2014)... ancestors of today,s crocodiles colonised the seas during warm ... a new Anglo-French study which establishes a link between ... over a period of more than 140 million years. ... from the Universit de Lyon, France and formerly from ... in Nature Communications ., Today, crocodiles are ,cold-blooded, ...
(Date:8/19/2014)... fizzy soda knows that bubbles can throw tiny particles ... industrial applications, Princeton researchers have demonstrated that the bursting ... well. , "It is well known that bursting bubbles ... to discover that when we covered the water with ... the water," said Howard Stone, the Donald R. Dixon ...
Breaking Biology News(10 mins):Biomarker in an aggressive breast cancer is identified 2Biomarker in an aggressive breast cancer is identified 3Evolution of marine crocodilians constrained by ocean temperatures 2Bubbling down: Discovery suggests surprising uses for common bubbles 2Bubbling down: Discovery suggests surprising uses for common bubbles 3
... wringing every drop of energy from as many photons ... chemistry, materials science and electronic engineering researchers on a ... but existing techniques are now running up against limits ... Now, researchers from the University of Pennsylvania and Drexel ...
... BURLINGTON, Mass. , Nov. 12, 2013  Decision Resources, ... for pharmaceutical and healthcare issues, finds that while most ... play a critical role in pharmaceutical development of chronic ... outside of oncology is building. The Strategic Insights report ...
... more meat, milk and eggs in their diets. Increased ... livestock production and massive environmental consequences at local, regional ... Treatment and Management, draws from Danish expertise and spotlights ... work and ensure the use of animal manure,s stinking ...
Cached Biology News:Penn and Drexel team demonstrates new paradigm for solar cell construction 2Penn and Drexel team demonstrates new paradigm for solar cell construction 3Penn and Drexel team demonstrates new paradigm for solar cell construction 4Penn and Drexel team demonstrates new paradigm for solar cell construction 5Use of Biomarkers in Clinical Trials for Drugs Outside of Oncology is Increasing 2New textbook tackles the sustainable recycling of manure 2
(Date:8/19/2014)... 20, 2014 One of the ... is an inadequate vascular supply. Nutrient and gas ... tissues is critical for successful regeneration and integration ... mitigate deficiencies in vascularization and promote angiogenesis in ... optimizing scaffold design and architecture, and enhancing scaffolds ...
(Date:8/19/2014)... (PRWEB) August 19, 2014 Shimadzu ... chromatography systems, Prominence-i and Nexera-i, adding to the ... Combining excellent functionality, an intuitive operating environment, and ... a more efficient workflow for conventional to ultra-high-speed ... innovative, intuitive and intelligent design so users can ...
(Date:8/19/2014)... Research and Markets  has announced the addition of the ... report to their offering. This report analyzes the ... by the following Product Segments: Media, Sera, and Reagents. ... Canada , Japan , Europe ... America . Annual estimates and forecasts are provided for the ...
(Date:8/19/2014)... 19, 2014 A Geisinger researcher on a ... a Centers for Disease Control and Prevention (CDC) award ... health concern. Joseph Boscarino , Ph.D. ... a team of researchers nominated for the Centers for ... Award for Data Methods and Study Design. ...
Breaking Biology Technology:Vascularization in Tissue Engineering Highlighted at 12th New Jersey Symposium on Biomaterials Science 2Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 2Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 3Global Cell and Tissue Culture Supplies - Strategic Business Report 2014 2Geisinger investigator nominated for federal award 2Geisinger investigator nominated for federal award 3
... Advanced Instruments, Inc., of,Norwood, Massachusetts, announced today ... D & F Control Systems, Inc., of Dublin, ... D & F Control Systems manufactures and ... laboratories around the world. Their,patented preservatives ensure component ...
... Operations Appointed -, CLINTON, N.J., Oct. 2 ... Michael Kennedy as Senior Vice President,Engineering and Operations. ... technology strategy and development., "Michael,s extensive experience ... as we continue to advance our pharmaceutical,pipeline through ...
... the largest non-state-owned producers of ... plasma-based product in China, ... (OTC Bulletin Board: CBPO) ("China Biologic" or the,"Company"), one of ... ("PRC"), today announced that on September 26,2008, the Company has ...
Cached Biology Technology:Advanced Instruments Acquires D & F Control Systems Inc. 2Ikaria Strengthens Executive Leadership Team 2China Biologic Products Enters Into Agreement to Acquire 90% Controlling Interest in Chongqing Dalin Biologic Technologies Co., Ltd. 2China Biologic Products Enters Into Agreement to Acquire 90% Controlling Interest in Chongqing Dalin Biologic Technologies Co., Ltd. 3China Biologic Products Enters Into Agreement to Acquire 90% Controlling Interest in Chongqing Dalin Biologic Technologies Co., Ltd. 4China Biologic Products Enters Into Agreement to Acquire 90% Controlling Interest in Chongqing Dalin Biologic Technologies Co., Ltd. 5
... SB3, Fully adjustable mixing angle, Variable speed, ... hold a number of different sized tubes, ... aerating cultures, keeping biological samples in suspension ... can be used in incubators up to ...
...
Fingerprinting II database sharing tools is an optional module for the Fingerprinting II Basic software package that enables peer-to-peer data exchange over the internet and provides external databas...
Fingerprinting II cluster analysis is an optional module that adds dendrogram and phylogenetic tree construction, cluster and group significance, and congruence of techniques functions to the Fingerp...
Biology Products: