Navigation Links
Scientists of Helmholtz Zentrum Muenchen and TU Muenchen elucidate structure details of protein Sam68
Date:9/10/2010

This release is available in German.

The renowned Journal of Biological Chemistry has selected the report of these research findings as one of two "papers of the week" for its September 10, 2010 issue and has chosen the structural model as cover image.

Using NMR spectroscopy, Professor Michael Sattler and his team elucidated the spatial structure of the Qua1 region of Sam68, which is responsible for the dimerization of the protein. In collaboration with the research group of Professor Ruth Brack-Werner of the Institute of Virology, the authors showed that this region is essential for the biological function of Sam68. The image reveals an unusual spatial structure, in which two helices of respectively one Qua1 region (green and blue) interact with each other and mediate the dimerization of Qua1 and thus of Sam68.

Sam68 belongs to the family of STAR proteins which carry out important tasks in the signal-regulated processing of genetic information and its translation into protein. Among others, Sam68 regulates specific processes linked to the cell cycle and apoptosis and plays a key role in the pathogenesis of cancer.


'/>"/>

Contact: Sven Winkler
presse@helmholtz-muenchen.de
49-089-318-73946
Helmholtz Zentrum Mnchen - German Research Center for Environmental Health
Source:Eurekalert

Page: 1

Related biology news :

1. CRISPR critters: Scientists identify key enzyme in microbial immune system
2. Storm Surges Congress 2010 -- scientists from 30 countries meet in Hamburg
3. Transition metal catalysts could be key to origin of life, scientists report
4. Scientists identify molecules involved in touch and other mechanically activated systems
5. Scientists discover new protein that gets to the roots of obesity and osteoporosis
6. Scientists concerned about environmental impact of recycling of e-waste
7. Plant scientists move closer to making any crop drought-tolerant
8. Scripps Research scientists uncover new mechanism of memory formation
9. New Naked Scientists series investigates our oceans
10. NSU scientists receive BP money to research oil spills impact
11. Smithsonian scientists help create first frozen repository for Hawaiian coral
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2017)... April 13, 2017 UBM,s Advanced Design and ... will feature emerging and evolving technology through its 3D ... will run alongside the expo portion of the event ... and demonstrations focused on trending topics within 3D printing ... and manufacturing event will take place June 13-15, 2017 at ...
(Date:4/11/2017)... Research and Markets has announced the addition of the ... ... to grow at a CAGR of 30.37% during the period 2017-2021. ... been prepared based on an in-depth market analysis with inputs from ... prospects over the coming years. The report also includes a discussion ...
(Date:4/6/2017)... Forecasts by Product Type (EAC), Biometrics, Card-Based ... & Logistics, Government & Public Sector, Utilities / Energy ... Nuclear Power), Industrial, Retail, Business Organisation (BFSI), Hospitality & ... for a definitive report on the $27.9bn Access Control ... ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... Proscia ... be hosting a Webinar titled, “Pathology is going digital. Is your lab ready?” ... pathology adoption best practices and how Proscia improves lab economics and realizes an ...
(Date:10/11/2017)... ... October 11, 2017 , ... Singh Biotechnology today announced ... to SBT-100, its novel anti-STAT3 (Signal Transducer and Activator of Transcription 3) B ... to cross the cell membrane and bind intracellular STAT3 and inhibit its function. ...
(Date:10/10/2017)... research firm Parks Associates announced today that Tom Kerber ... Annual Meeting , October 11 in Scottsdale, Arizona . ... how smart safety and security products impact the competitive landscape. ... Parks Associates: Smart Home Devices: Main Purchase Driver ... "The residential security market has experienced continued growth, and the ...
(Date:10/9/2017)... ... ... The award-winning American Farmer television series will feature 3 Bar Biologics in ... 8:30aET on RFD-TV. , With global population estimates nearing ten billion people by ... feed a growing nation. At the same time, many of our valuable resources are ...
Breaking Biology Technology: