Navigation Links
Scientists of Helmholtz Zentrum Muenchen and TU Muenchen elucidate structure details of protein Sam68
Date:9/10/2010

This release is available in German.

The renowned Journal of Biological Chemistry has selected the report of these research findings as one of two "papers of the week" for its September 10, 2010 issue and has chosen the structural model as cover image.

Using NMR spectroscopy, Professor Michael Sattler and his team elucidated the spatial structure of the Qua1 region of Sam68, which is responsible for the dimerization of the protein. In collaboration with the research group of Professor Ruth Brack-Werner of the Institute of Virology, the authors showed that this region is essential for the biological function of Sam68. The image reveals an unusual spatial structure, in which two helices of respectively one Qua1 region (green and blue) interact with each other and mediate the dimerization of Qua1 and thus of Sam68.

Sam68 belongs to the family of STAR proteins which carry out important tasks in the signal-regulated processing of genetic information and its translation into protein. Among others, Sam68 regulates specific processes linked to the cell cycle and apoptosis and plays a key role in the pathogenesis of cancer.


'/>"/>

Contact: Sven Winkler
presse@helmholtz-muenchen.de
49-089-318-73946
Helmholtz Zentrum Mnchen - German Research Center for Environmental Health
Source:Eurekalert

Page: 1

Related biology news :

1. CRISPR critters: Scientists identify key enzyme in microbial immune system
2. Storm Surges Congress 2010 -- scientists from 30 countries meet in Hamburg
3. Transition metal catalysts could be key to origin of life, scientists report
4. Scientists identify molecules involved in touch and other mechanically activated systems
5. Scientists discover new protein that gets to the roots of obesity and osteoporosis
6. Scientists concerned about environmental impact of recycling of e-waste
7. Plant scientists move closer to making any crop drought-tolerant
8. Scripps Research scientists uncover new mechanism of memory formation
9. New Naked Scientists series investigates our oceans
10. NSU scientists receive BP money to research oil spills impact
11. Smithsonian scientists help create first frozen repository for Hawaiian coral
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/15/2016)... 2016  Synthetic Biologics, Inc. (NYSE MKT: SYN), ... the gut microbiome, today announced the pricing of ... its common stock and warrants to purchase 50,000,000 ... to the public of $1.00 per share and ... the offering, excluding the proceeds, if any from ...
(Date:6/27/2016)... 2016 Research and Markets has announced the ... report to their offering. The ... to grow at a CAGR of 12.28% during the period ... an in-depth market analysis with inputs from industry experts. The report ... years. The report also includes a discussion of the key vendors ...
(Date:6/21/2016)... British Columbia , June 21, 2016 /PRNewswire/ ... appointed to the new role of principal product ... been named the director of customer development. Both ... NuData,s chief technical officer. The moves reflect NuData,s ... teams in response to high customer demand and ...
Breaking Biology News(10 mins):
(Date:12/8/2016)... Oxford Gene Technology ... Palette an anpassbaren SureSeq™ NGS-Panels mit dem Start ... ein schnelles und kostengünstiges Studium der Varianten bei ... Erkennung von Einzel-Nukleotid-Variationen (Single Nucleotide Variation, SNV) und ... Panel und ermöglicht eine individuelle Anpassung durch die ...
(Date:12/8/2016)... ... December 08, 2016 , ... Microbial genomics leader, uBiome, joins ... one of just six company finalists in the Health & Medicine category. Over ... nominated as finalists in this year’s awards include Google, SpaceX, Oculus, and SolarCity. ...
(Date:12/8/2016)... , Dec. 8, 2016 Savannah ... remediation technologies and selected NewTechBio,s NT-MAX Lake ... microbial based beneficial bacteria, in conjunction with Hexa ... correct deficiencies with National Pollutant Discharge Elimination System ... has experienced a steady history of elevated pH ...
(Date:12/7/2016)... ... December 07, 2016 , ... A new study published ... of previously treated, advanced pancreatic cancer, liquid biopsies are not yet an adequate ... timing of blood sampling may improve the value of a blood-based test.” The ...
Breaking Biology Technology: