Navigation Links
Scientists notch a win in war against antibiotic-resistant bacteria
Date:2/4/2013

currently understand E. coli metabolism. Collins' team began by adding to this "system-level" metabolic model hundreds of reactions that are known to increase ROS production. Then they deleted various genes to see which were involved in ROS production, honed in on the suspected targets after running thousands of computer simulations, and validated the model in the laboratory -- achieving 80-90% agreement with the model-based predictions.

"The next challenge was to determine if increasing the ROS production by the cell itself would render it more susceptible to death by oxidative, ergo, antibiotic attack," Collins said -- and it did. The team deleted a series of genes that led to increased ROS production in the cell, added different antibiotics and biocides such as bleach known cell-killers by way of increasing ROS production and the cells died at a much higher rate than the cells without the deleted genes. In short, by interfering with the bacterial metabolism, the antibiotics and biocides were even more lethal to the cells.

"There is no magic bullet for the global health crisis we're experiencing in terms of antibiotic-resistant bacteria," said Don Ingber, M.D., Ph.D., Wyss Founding Director, "and yet there is tremendous hope in the kinds of pioneering systems biology approaches Jim and his team are spearheading."

The team's next steps are to use molecular screening technologies to precisely identify molecules that boost ROS production, Collins said, and to test the approach used in this E. coli study on other kinds of bacteria -- such as the mycobacteria responsible for tuberculosis, a potentially lethal lung disease.


'/>"/>

Contact: Kristen Kusek
kristen.kusek@wyss.harvard.edu
617-432-8266
Wyss Institute for Biologically Inspired Engineering at Harvard
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Plant scientists at CSHL demonstrate new means of boosting maize yields
2. Listening to cells: Scientists probe human cells with high-frequency sound
3. A*STAR scientists solve century-old mystery by finding stable haploid strains of Candida albicans
4. Joslin scientists find first human iPSC from patients with maturity onset diabetes of the young
5. Scientists uncover previously unknown mechanism of memory formation
6. Scientists trick iron-eating bacteria into breathing electrons instead
7. Damon Runyon Cancer Research Foundation grants prestigious awards to 17 young scientists
8. Virginia Tech computer scientists develop new way to study molecular networks
9. UCI neuroscientists create fiber-optic method of arresting epileptic seizures
10. Scientists discover needle in a haystack for muscular dystrophy patients
11. Just add water: How scientists are using silicon to produce hydrogen on demand
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists notch a win in war against antibiotic-resistant bacteria
(Date:9/29/2014)... Food and Brand Lab pilot study, published in ... National School Lunch Program (NSLP) by 9% and overall ... Move to Schools (CMTS), an initiative of Michelle Obama,s ... to provide nutrition instruction to students and culinary advice ... event was held in an Upstate New York high ...
(Date:9/29/2014)... PULLMAN, Wash. Scientists at Washington State University ... specifically, Granny Smith apples may help prevent ... be the first to assess these compounds in ... in October,s print edition of the journal ... apples are a good source of these nondigestible ...
(Date:9/29/2014)... decades, planetary geologists have speculated that glaciers might ... chasm that constitutes the Grand Canyon of Mars. ... might have been carved by past glaciers as ... have remained highly controversial and contested. , ... and the Freie Universitaet Berlin has identified what ...
Breaking Biology News(10 mins):Chefs move to schools can increase school meal participation and vegetable intake among students 2An apple a day could keep obesity away 2Glaciers in the Grand Canyon of Mars? 2Glaciers in the Grand Canyon of Mars? 3Glaciers in the Grand Canyon of Mars? 4Glaciers in the Grand Canyon of Mars? 5Glaciers in the Grand Canyon of Mars? 6Glaciers in the Grand Canyon of Mars? 7Glaciers in the Grand Canyon of Mars? 8Glaciers in the Grand Canyon of Mars? 9
... thousands of people suffer medical complications from hypodermic needles ... device developed by MIT engineers and colleagues aims to ... The device, which is purely mechanical, is based ... a hollow S-shaped needle containing a filament that acts ...
... that gives greatest protection from heart attack and stroke. In ... researchers showed that one, DHPEA-EDA, protects red blood cells from ... "These findings provide the scientific basis for the clear health ... oil in their diet," says lead researcher Fatima Paiva-Martins, who ...
... have come to agree that different environments impact the ... University of British Columbia are showing for the first ... from the UBC Biodiversity Research Centre created mini-ecosystems in ... fish and saw substantial differences in the ecosystems in ...
Cached Biology News:MIT: Novel needle could cut medical complications 2UBC study first to show evolution's impact on ecosystems 2
(Date:9/29/2014)... METTLER TOLEDO’s new line of XPE balances includes ... balances as well as automated dosing with the ... out their daily weighing tasks worry free, safe in ... reliable and compliant results, thanks to new technologies such ... biggest challenges in analytical and micro-analytical weighing – electrostatic ...
(Date:9/29/2014)... 29, 2014  Perrigo Company plc (NYSE: ... has transferred a portfolio of preclinical research assets, ... of Elan Corporation plc, to drug discovery and ... agreement, Perrigo will receive an upfront payment in ... on any future sales derived from the portfolio. ...
(Date:9/29/2014)... September 29, 2014 Westbridge Agricultural ... Herbicide EC, a highly effective new tool for ... a broad spectrum contact herbicide for post-emergent, non-selective ... and non-food crops. The formulation is an emulsifiable ... Materials Review Institute (OMRI) for use in organic ...
(Date:9/27/2014)... This news release is available in German . ... electron microscope is not only used for precisely surveying ... their chemical compositions. This is done by exciting the ... while scanning the sample. This secondary emission provides information ... the analysis is sufficiently precise. However, the lighter elements ...
Breaking Biology Technology:New Line of XPE Balances from METLER TOLEDO is Designed for High Performance and Ease of Compliance 2Perrigo Announces the Out-Licensing of Preclinical Assets to Imago Pharmaceuticals 2Perrigo Announces the Out-Licensing of Preclinical Assets to Imago Pharmaceuticals 3Perrigo Announces the Out-Licensing of Preclinical Assets to Imago Pharmaceuticals 4Westbridge Receives EPA Approval for Its New SUPPRESS™ Herbicide EC 2'Multi-spectra glasses' for scanning electron microscopy 2
... to them. We've heard a lot of chatter about improving ... lost in that clamor is the thought that you need ... can hope to improve it. Apparently, even if you're Britney ... also don't want to confuse the kinds of business relationships ...
... MADISON, Wis. -- What's more important to a manufacturing company: ... Center for Quick Response Manufacturing , ruthlessly cutting down the ... seen as the best way to reduce costs and end ... ,"It's not usually about buying new equipment," Frank Rath, associate ...
... left, and Charletta D. Flowers, right, who work for Milwaukee-based ... for the Energizer Battery Company in St. Louis. On ... Milwaukee (YPM) threw an elaborate party at Milwaukee's ... group had a lot to be proud of. In the ...
Cached Biology Technology:Customers, clients and partners, oh my! 2Customers, clients and partners, oh my! 3University center offers speed boost to manufacturers 2Young Professionals of Milwaukee Celebrates Its Third Birthday, Looks To The Future 2Young Professionals of Milwaukee Celebrates Its Third Birthday, Looks To The Future 3
Chicken polyclonal to QPRT ( Abpromise for all tested applications). Antigen: Synthetic peptide, corresponding to Internal sequence amino acids 123-237 of Human QPRT Entrez Gene ID: 23475 ...
...
Protein Marker Detection Pack contains biotinylate...
...
Biology Products: