Navigation Links
Scientists move closer to predicting who will and will not fight off severe infections
Date:10/12/2011

Bethesda, MD -- Why are some people prone to severe infections, while others handle them with less difficulty? A new research report appearing online in the FASEB Journal (http://www.fasebj.org) attempts to answer this question by shedding light on the genetic differences that influence our ability to fight off bacterial infections.

In the report, scientists analyzed the diversity (polymorphisms) in the genetic makeup of an immune system mediator called the macrophage migration inhibitory factor, or MIF, which plays an important role in host defenses against infection. By identifying the gene variations in people that influence the likelihood of developing deadly infections, new tools can be developed to help physicians prescribe the best treatment and approach toward conditions ranging from childhood ear infections to post-surgical recoveries.

"We hope that our study will contribute to facilitating the development of novel treatment strategies targeting the mediator MIF in patients with severe infection (i.e., sepsis) or any other diseases in which MIF has been shown to play an important role," said Thierry Calandra, Ph.D., a researcher involved in the work from the Infectious Diseases Service in the Department of Medicine at the Centre Hospitalier Universitaire Vaudois in Lausanne, Switzerland.

To make their discovery, Calandra and colleagues defined the genetic variations of the MIF gene in a group of children with bacterial sepsis and found that a specific variant of the MIF gene was associated with more severe disease and increased mortality. They also analyzed the transmission of genetic variants of the MIF gene from parents to afflicted children. Results from this family study suggested that one specific variant of the MIF gene protects from meningitis during childhood, while another variant is a risk factor for the development of infection. Considering the existence of a link
'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Tagging tumors with gold: Scientists use gold nanorods to flag brain tumors
2. Uncharted territory: Scientists sequence the first carbohydrate biopolymer
3. New drug target for Alzheimers, stroke is discovered by University at Buffalo scientists
4. Scientists discover 3 new gene faults which could increase melanoma risk by 30 percent
5. Scientists identify microbes responsible for consuming natural gas in Deepwater Horizon spill
6. University of Texas marine scientists awarded $5.6 million for study of critical Arctic environment
7. Responsibilities of scientists underlined by scientific community
8. 11 women scientists announced as winners of Elsevier Foundation OWSD awards
9. Scientists discover the proteins that control development of varicose veins
10. Carnegie Mellon scientists track neuronal stem cells using MRI
11. Scientists discover a master key to unlock new treatments for autoimmune disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2015)... 14, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... focused on the growing mobile commerce market, announces that ... 2015 New York Design Awards under the category  ,Product ... City Design Awards are part of a global multi-disciplinary ... ratings from the marketplace, industry and judging panel. Winners ...
(Date:4/13/2015)... April 13, 2015  higi, a leading cloud-based consumer ... more fully engage with their communities around health and ... protected and secure API.  ... most accessible, affordable, and convenient vehicle to receive validated ... The API will allow higi,s trusted ...
(Date:4/9/2015)... April 9, 2015 Synaptics Inc. (NASDAQ: SYNA ... today that it will report financial results for the ... 2015, after the close of market. The company will ... at 2:00 p.m. PT (5:00 p.m. ET), during which ... participate on the live call, analysts and investors should ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3Synaptics to Report Third Quarter Results on April 23 2
... endometrium (uterine lining) and transplanted into the brains of ... of brain cells damaged by the disease, according to ... The findings are published in the ... are preliminary results, the findings increase the likelihood that ...
... NEW YORK (May 6, 2010) The Wildlife ... of a large, "landscape-wide" conservation approach to protect globally ... study looked at wildlife populations in northern Republic of ... national park, a community-managed reserve, and various logging concessions. ...
... produced the first whole genome sequence of the 3 billion ... that up to 2 percent of the DNA in the ... or in Neanderthals, ancestors. The international research ... Institute (NHGRI), part of the National Institutes of Health, reports ...
Cached Biology News:Endometrial stem cells could repair brain cells damaged by Parkinson's disease 2Study looks at gorillas, elephants and logging in Congo 2Study looks at gorillas, elephants and logging in Congo 3Complete Neanderthal genome sequenced 2Complete Neanderthal genome sequenced 3Complete Neanderthal genome sequenced 4Complete Neanderthal genome sequenced 5
(Date:5/1/2015)... , May 1, 2015 ... Production Market by Product (Equipment, Consumables), by Type (Monoclonal, ... Diagnostic Labs, Research Institutes) - Analysis & Global ... studies the global Antibody Production Market for the ... is expected to reach $2.572 Billion by 2019 ...
(Date:4/30/2015)... Spirax Sarco, the leader in product ... announce that for the first time in the company’s ... a Queen’s Award for Innovation – the UK’s highest ... of a unique flowmeter. , The Spirax Sarco ... steam flow measurement. The device provides reliable, accurate ...
(Date:4/30/2015)... --  Tamir Biotechnology , a leading developer of RNA ... antiviral therapy program. Clinical Progress ... evaluated and considered by a number of clinicians on ... first quarter of 2015, the company participated in the ... of Potential Treatments and Vaccines For Ebola In West ...
(Date:4/30/2015)... /PRNewswire/ - BioAmber Inc. (NYSE: BIOA ), an ... has commenced an underwritten public offering of its common ... a 30-day option to purchase up to an additional ... in the public offering. The offering is subject to ... to whether or when the offering may be completed, ...
Breaking Biology Technology:Antibody Production Market worth $2.572 Billion by 2019 2Antibody Production Market worth $2.572 Billion by 2019 3Antibody Production Market worth $2.572 Billion by 2019 4Spirax Sarco Receives a Queen’s Award for Innovation 2Spirax Sarco Receives a Queen’s Award for Innovation 3Tamir Biotechnology Provides Update on TMR004 Development Against Mutating Ebola 2Tamir Biotechnology Provides Update on TMR004 Development Against Mutating Ebola 3Tamir Biotechnology Provides Update on TMR004 Development Against Mutating Ebola 4BioAmber Inc. Announces Public Offering Of Common Stock 2BioAmber Inc. Announces Public Offering Of Common Stock 3
... VoIP (voice over internet protocol) has been a long time ... have been nervously looking over our shoulder as VoIP technology ... first greeted it with a confident snicker or brash statements ... work, they dont understand Telephony! But time passed and Telephonys ...
... topics of this newsletter hit a nerve as sharply as social ... on this topic than I seem to receive on all other ... things get a little lonely in my office.) , ,Last week, ... fundamental sense." , ,I said, "The value is in actively ...
... The MIT Club of Wisconsin is recognizing nPoint, ... technological innovation. nPoint, a Madison-based provider of motion devices ... of three winners of the annual 2004 MIT Club ... Club of Wisconsin consists of alumni of the Massachusetts ...
Cached Biology Technology:A telecom person in an VoIP world 2Social networks: Readers respond 2Social networks: Readers respond 3Social networks: Readers respond 4
Request Info...
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5...
...
RayBio L Series 507: RayBio Label-based Antibody Array I (1 glass slide with 2 subarrays) Class: Antibody Array Products Product Group: Antibody Array...
Biology Products: