Navigation Links
Scientists move closer to predicting who will and will not fight off severe infections
Date:10/12/2011

Bethesda, MD -- Why are some people prone to severe infections, while others handle them with less difficulty? A new research report appearing online in the FASEB Journal (http://www.fasebj.org) attempts to answer this question by shedding light on the genetic differences that influence our ability to fight off bacterial infections.

In the report, scientists analyzed the diversity (polymorphisms) in the genetic makeup of an immune system mediator called the macrophage migration inhibitory factor, or MIF, which plays an important role in host defenses against infection. By identifying the gene variations in people that influence the likelihood of developing deadly infections, new tools can be developed to help physicians prescribe the best treatment and approach toward conditions ranging from childhood ear infections to post-surgical recoveries.

"We hope that our study will contribute to facilitating the development of novel treatment strategies targeting the mediator MIF in patients with severe infection (i.e., sepsis) or any other diseases in which MIF has been shown to play an important role," said Thierry Calandra, Ph.D., a researcher involved in the work from the Infectious Diseases Service in the Department of Medicine at the Centre Hospitalier Universitaire Vaudois in Lausanne, Switzerland.

To make their discovery, Calandra and colleagues defined the genetic variations of the MIF gene in a group of children with bacterial sepsis and found that a specific variant of the MIF gene was associated with more severe disease and increased mortality. They also analyzed the transmission of genetic variants of the MIF gene from parents to afflicted children. Results from this family study suggested that one specific variant of the MIF gene protects from meningitis during childhood, while another variant is a risk factor for the development of infection. Considering the existence of a link between variations in the MIF gene, MIF expression, and the development of bacterial sepsis in children, this study data may help identify patients who may benefit from future treatment strategies targeting MIF.

"It's a big step towards personalized medicine. Knowing exactly how the body is programmed to fight infection will prove to be so critical to physicians of the future that new medical school graduates won't be able to imagine how their professors managed without it," said Gerald Weissmann, M.D., Editor-in-Chief of the FASEB Journal. "Here's an analogy: ask a college senior to describe daily life in a world without computers."


'/>"/>
Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. Tagging tumors with gold: Scientists use gold nanorods to flag brain tumors
2. Uncharted territory: Scientists sequence the first carbohydrate biopolymer
3. New drug target for Alzheimers, stroke is discovered by University at Buffalo scientists
4. Scientists discover 3 new gene faults which could increase melanoma risk by 30 percent
5. Scientists identify microbes responsible for consuming natural gas in Deepwater Horizon spill
6. University of Texas marine scientists awarded $5.6 million for study of critical Arctic environment
7. Responsibilities of scientists underlined by scientific community
8. 11 women scientists announced as winners of Elsevier Foundation OWSD awards
9. Scientists discover the proteins that control development of varicose veins
10. Carnegie Mellon scientists track neuronal stem cells using MRI
11. Scientists discover a master key to unlock new treatments for autoimmune disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/3/2016)... Calif. , Feb. 3, 2016 Vigilant ... Police Department in Missouri ... license plate reader (LPR) data from Vigilant Solutions. ... hit-and-run case in which the victim was walking out of a convenience ... parking space next to his vehicle, striking his vehicle ...
(Date:2/2/2016)... Feb. 2, 2016 Checkpoint Inhibitors for ... Market Are you interested in the future ... for checkpoint inhibitors. Visiongain,s report gives those predictions ... and national level. Avoid falling behind in ... opportunities and revenues those emerging cancer therapies can ...
(Date:2/1/2016)... 1, 2016 Rising sales of ... global touchfree intuitive gesture control market size ... sales of consumer electronics coupled with new technological advancements ... size through 2020   --> ... new technological advancements to drive global touchfree intuitive gesture ...
Breaking Biology News(10 mins):
(Date:2/8/2016)... Feb. 8, 2016  CytRx Corporation (NASDAQ: ... specializing in oncology, today announced that it has ... with Hercules Technology Growth Capital, Inc. and Hercules ... in financing. --> ... million of financing under the loan and security ...
(Date:2/8/2016)... Novan, Inc. today announced that Director Robert A. Ingram ... In addition, Robert Keegan has been appointed to the ... --> North Carolina . ... of $32.8 million of net proceeds in a private Mezzanine B ... the Research Triangle area of North Carolina . ...
(Date:2/8/2016)... 2016  BioElectronics Corporation (OTC Pink: BIEL), the ... that it is responding to a notice of ... and Exchange Commission posted on the agency website.  ... the Board of BioElectronics Corporation and the Edward ... The Fuqua School of Business, Duke University.   ...
(Date:2/8/2016)... ... February 08, 2016 , ... Bulk food product ... foods at various stages of the production process. Despite frequently inspecting loose product ... products post packaging such as sacks of dry powders. , Mettler-Toledo Product Inspection's ...
Breaking Biology Technology: