Navigation Links
Scientists model the pathways of pain-blocking meds
Date:9/26/2011

Benzocaine, a commonly used local anesthetic, may more easily wiggle into a cell's membrane when the membrane is made up of compounds that carry a negative charge, a new study shows. The finding could help scientists piece together a more complete understanding of the molecular-level mechanisms behind pain-blocking medicines, possibly leading to their safer and more effective use.

Most scientists believe that local anesthetics prevent pain signals from propagating to the central nervous system by blocking nerve cells' sodium channels, but exactly how the medicines accomplish this feat remains vague. Since the solubility of anesthetics in the cell membrane can affect the medicine's potency, some scientists have hypothesized that certain anesthetics may block the action of sodium channels indirectly, by entering the cell membrane and jostling the channels into a new shape that prevents ion flow.

With the aim of further investigating such complex processes, scientists from the Universidad Politecnica de Cartagena in Spain and the Universidad Nacional de San Luis in Argentina have created a computer model that calculates the probability of molecules of benzocaine entering a cell's membrane, based on the composition of the membrane.

As reported in the AIP's Journal of Chemical Physics, the model predicts that membranes made of a large percentage of DPPS, a negatively charged phospholipid component of cells, present less of a barrier to benzocaine molecules than membranes made mostly of DPPC, a neutral phospholipid. DPPS is normally found as one of the main components of cell membranes in the central nervous system, as well as a component of the inner side of membranes in other humans cells.


'/>"/>

Contact: Catherine Meyers
cmeyers@aip.org
301-209-3088
American Institute of Physics
Source:Eurekalert

Page: 1

Related biology news :

1. Scientists lay out plans for efficient harvesting of solar energy
2. Scientists probe Indian Ocean for clues to worldwide weather patterns
3. Ties between scientists in South Africa and Europe to strengthen
4. NIH Directors Awards go to 3 Johns Hopkins scientists
5. 2 Scripps Research scientists win prestigious NIH Innovator Awards
6. Scientists turn back the clock on adult stem cells aging
7. Texas AgriLife Research scientists making better melons
8. Scientists reveal how organisms avoid carbon monoxide poisoning
9. Bulletin of the Atomic Scientists publishes Japanese translation of special Fukushima issue
10. Scientists solve long-standing plant biochemistry mystery
11. Online gamers succeed where scientists fail, opening door to new AIDS drug design
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... Lithuania , May 3, 2016  Neurotechnology, ... released the MegaMatcher Automated Biometric Identification System ... of large-scale multi-biometric projects. MegaMatcher ABIS can process ... accuracy using any combination of fingerprint, face or ... MegaMatcher SDK and MegaMatcher Accelerator ...
(Date:4/19/2016)... 2016 The new GEZE SecuLogic ... web-based "all-in-one" system solution for all door components. It ... the door interface with integration authorization management system, and ... The minimal dimensions of the access control and the ... installations offer considerable freedom of design with regard to ...
(Date:3/31/2016)... Florida , March 31, 2016 ... ) ("LegacyXChange" or the "Company") LegacyXChange ... potential users of its soon to be launched online ... ( https://www.youtube.com/channel/UCyTLBzmZogV1y2D6bDkBX5g ) will also provide potential ... use of DNA technology to an industry that is ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... Regulatory Compliance ... consulting, provides a free webinar on Performing Quality Investigations: Getting to ... 12pm CT at no charge. , Incomplete investigations are still a major concern ...
(Date:6/23/2016)...  Amgen (NASDAQ: AMGN ) today announced ... life sciences incubator to accelerate the development of new ... at QB3@953 was created to help high-potential life science ... early stage organizations - access to laboratory infrastructure. ... two "Amgen Golden Ticket" awards, providing each winner with ...
(Date:6/22/2016)... Cell Applications, Inc. and StemoniX announced ... up to one billion human induced pluripotent stem ... These high-quality, consistent stem cells enable researchers to ... more time doing meaningful, relevant research. This achievement ... process that produces affordable, reliable HiPSC for life ...
(Date:6/22/2016)... YORK , June 22, 2016  According ... growing next generation sequencing (NGS) market include significant ... of smaller sequencers.  More accessible and affordable sequencers, ... to growing demand for consumables including sample prep ... The Market for Sample Preparation for Next Generation ...
Breaking Biology Technology: