Navigation Links
Scientists model the pathways of pain-blocking meds
Date:9/26/2011

Benzocaine, a commonly used local anesthetic, may more easily wiggle into a cell's membrane when the membrane is made up of compounds that carry a negative charge, a new study shows. The finding could help scientists piece together a more complete understanding of the molecular-level mechanisms behind pain-blocking medicines, possibly leading to their safer and more effective use.

Most scientists believe that local anesthetics prevent pain signals from propagating to the central nervous system by blocking nerve cells' sodium channels, but exactly how the medicines accomplish this feat remains vague. Since the solubility of anesthetics in the cell membrane can affect the medicine's potency, some scientists have hypothesized that certain anesthetics may block the action of sodium channels indirectly, by entering the cell membrane and jostling the channels into a new shape that prevents ion flow.

With the aim of further investigating such complex processes, scientists from the Universidad Politecnica de Cartagena in Spain and the Universidad Nacional de San Luis in Argentina have created a computer model that calculates the probability of molecules of benzocaine entering a cell's membrane, based on the composition of the membrane.

As reported in the AIP's Journal of Chemical Physics, the model predicts that membranes made of a large percentage of DPPS, a negatively charged phospholipid component of cells, present less of a barrier to benzocaine molecules than membranes made mostly of DPPC, a neutral phospholipid. DPPS is normally found as one of the main components of cell membranes in the central nervous system, as well as a component of the inner side of membranes in other humans cells.


'/>"/>

Contact: Catherine Meyers
cmeyers@aip.org
301-209-3088
American Institute of Physics
Source:Eurekalert

Page: 1

Related biology news :

1. Scientists lay out plans for efficient harvesting of solar energy
2. Scientists probe Indian Ocean for clues to worldwide weather patterns
3. Ties between scientists in South Africa and Europe to strengthen
4. NIH Directors Awards go to 3 Johns Hopkins scientists
5. 2 Scripps Research scientists win prestigious NIH Innovator Awards
6. Scientists turn back the clock on adult stem cells aging
7. Texas AgriLife Research scientists making better melons
8. Scientists reveal how organisms avoid carbon monoxide poisoning
9. Bulletin of the Atomic Scientists publishes Japanese translation of special Fukushima issue
10. Scientists solve long-standing plant biochemistry mystery
11. Online gamers succeed where scientists fail, opening door to new AIDS drug design
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... -- A team of University of Maryland physicists ... other scientists say make possible new nanostructures and ... energy and quantum computing advances to new sensor ... of Nature Communications the Maryland scientists, ... for hybrid nanostructures that uses a connector, or ...
(Date:9/2/2014)... a new study that could ultimately lead to many ... Scripps Research Institute (TSRI) have adapted a chemical approach ... molecules that can treat a form of muscular dystrophy. ... and a disease-causing defect as a catalyst to synthesize ... Matthew Disney.,"Because the treatment is synthesized only in diseased ...
(Date:9/2/2014)... COLUMBUS, Ohio New research suggests that professional baseball pitchers ... or more days in a single season because of injury ... their lower back and pelvis. , In the study, 347 ... with more tilt in their pelvis as they raised a ... likely to miss at least 30 days cumulative, not ...
Breaking Biology News(10 mins):New synthesis method may shape future of nanostructures, clean energy 2New synthesis method may shape future of nanostructures, clean energy 3Scripps Florida scientists make diseased cells synthesize their own drug 2In pro baseball pitchers, weak core linked to more missed days 2In pro baseball pitchers, weak core linked to more missed days 3
... show that summertime storms in the southeastern United States shed ... from humans is likely driving that trend. The ... evident in data from NASA,s Tropical Rainfall Measuring Mission satellite, ... more rain and span a larger area across the Southeast ...
... Stowers Institutes Trainor Lab has demonstrated the role of ... nervous system, a process that requires coordination of differentiation ... division that increases their numbers. Until now, the mechanisms ... The findings will be published in the ...
... 28, 2008 -- As organic farming becomes more ... are increasingly important. In a recent study in ... isotopic discrimination to determine if non-organic, synthetic fertilizers ... at the Instituto Murciano de Investigacin y Desarrollo ...
Cached Biology News:NASA data link pollution to rainy summer days in the southeast 2NASA data link pollution to rainy summer days in the southeast 3Trainor Lab characterizes gene essential for prenatal development of nervous system 2Is it organic or not? 2
(Date:9/1/2014)... Reportlinker.com announces that a new market ... India Solid Waste Management Vehicles Market Forecast ... In India ... responsible for complete handling and regulation of solid ... 135,000 MT solid waste is generated daily in ...
(Date:9/1/2014)... The Collaborative R&D Terms and Agreements ... understanding and unprecedented access to the collaborative R&D ... leading life science companies. , The report provides ... why companies enter collaborative R&D deals. , Understanding ... terms provides critical insight into the negotiation process ...
(Date:8/31/2014)... 01, 2014 Available spectra is ... for research and cultivation of a wide range ... proprietary LEDs with proven patented and pending wide ... light uniformity in critical applications in contrast to ... , “Our customers have a large variety of ...
(Date:8/31/2014)... (PRWEB) August 31, 2014 This ... current state of the Epoxy Hardener industry ... basic overview of the industry, including definitions, applications ... Chinese domestic market analysis are provided with a ... of the market. A comparison between the international ...
Breaking Biology Technology:India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 2India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 3India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 4India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 5India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 6India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 7India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 8Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 2Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 3Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 4Epoxy Hardener Industry Development Trends in Global & China Regions Now Available at ReportsnReports.com 2Epoxy Hardener Industry Development Trends in Global & China Regions Now Available at ReportsnReports.com 3
... Including Launch of Key ... Bavituximab Phase II Cancer Program-, TUSTIN, Calif., March ... stage biopharmaceutical,company developing monoclonal antibodies for the treatment of cancer ... third quarter of fiscal year (FY) 2008 ended January 31, ...
... XI,AN, China, March 11 /Xinhua-PRNewswire-FirstCall/ -- China,Bionanometer ... company,within the bionanometer industry has formally signed ... with China Guangzhou,LGLY Advertising LTD., Guangzhou ... agency. It was,founded in December 1997 and ...
... Emerging Nanotechnologies (PEN) and National Science Foundation (NSF) ... the television series Nanotechnology: The Power of Small ... onlywill include remarks by U.S. Senator Ron Wyden ... , The series three programs explore critical questions ...
Cached Biology Technology:Peregrine Pharmaceuticals Reports Financial Results for the Third Quarter of Fiscal Year 2008 2Peregrine Pharmaceuticals Reports Financial Results for the Third Quarter of Fiscal Year 2008 3Peregrine Pharmaceuticals Reports Financial Results for the Third Quarter of Fiscal Year 2008 4Peregrine Pharmaceuticals Reports Financial Results for the Third Quarter of Fiscal Year 2008 5Peregrine Pharmaceuticals Reports Financial Results for the Third Quarter of Fiscal Year 2008 6Peregrine Pharmaceuticals Reports Financial Results for the Third Quarter of Fiscal Year 2008 7Peregrine Pharmaceuticals Reports Financial Results for the Third Quarter of Fiscal Year 2008 8Peregrine Pharmaceuticals Reports Financial Results for the Third Quarter of Fiscal Year 2008 9Peregrine Pharmaceuticals Reports Financial Results for the Third Quarter of Fiscal Year 2008 10CBIU Signs Agreement with LGLY Advertising LTD 2New nanotechnology television series does 'sweat the small stuff' 2
... is designed to deparaffinize and perform Heat ... paraffin-embedded tissue sections mounted on glass microscope ... paraffin at the high temperature used in ... of the paraffin by detergent. Formaldehyde fixation ...
NEWBORN CALF SERUM AND PLASMA...
...
Synaptic Vesicle I Sampler Kit 10g each...
Biology Products: