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Scientists make stunning inner space observations
Date:5/1/2012

trometry Facility led by Dr Duncan Smith at the Paterson Institute for Cancer Research (Manchester) to investigate a protein, called Hrs1/Mcp6, responsible for the development of the rMTOC structure.

Dr Tanaka added: "In addition, collaboration with Dr Smith and his colleagues was fantastic, without their help, it would not have been possible to prove all the modifications of the Hrs1/Mcp6 molecule.

"Taken together with cell biological analyses done by Dr Shivanthi Samarasinghe in my lab, we reveal that the dynamic microtubule rearrangement involves transient generation of a specialized structure, rMTOC, which is later subjected to a rigorous down-regulation to support a smooth transition to the next stage. As Hrs1/Mcp6 has likely mammalian counterparts, this paradigm of rigorously controlled, transient, specialized structures to organise micorutuble architecture may be conserved across species.

"The storyline, or our hypothesis, of our work existed more than 5 years ago when I came to Leicester to start my own lab for the first time. I have always wanted to prove it... and it is almost surreal to finally obtain substantial evidences that support our hypothesis."


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Contact: Dr. Kayoko Tanaka
kt96@leicester.ac.uk
University of Leicester
Source:Eurekalert  

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