Navigation Links
Scientists make strides toward defining genetic signature of Alzheimer's disease
Date:12/31/2008

Scientists have new information about the complex genetic signature associated with Alzheimer's disease, the leading cause of cognitive decline and dementia in the elderly. The research, published by Cell Press in the January issue of the American Journal of Human Genetics, uses a powerful, high-resolution analysis to look for genes associated with this devastating neurodegenerative disorder.

Previous research linked late-onset Alzheimer's disease, the most common form, with the apolipoprotein E gene. However, the genetics of the disease are complex and are not well understood. "Though apolipoprotein E has been universally confirmed as a risk gene for late-onset Alzheimer's disease, the gene is neither necessary nor sufficient to cause AD and as much as 50% of the genetic risk effect remains unexplained," says senior study author Dr. Margaret A. Pericak-Vance from the Miami Institute for Human Genomics at the University of Miami in Florida.

To gain further insight into the genetics of late-onset Alzheimer's disease, Dr. Pericak-Vance and colleagues completed a sophisticated and comprehensive genetic analysis of 492 late-onset Alzheimer's disease patients and 498 control individuals. The analysis was powerful enough to detect single nucleotide polymorphisms (SNPs) that are significantly more prevalent in individuals with Alzheimer's disease than they are in controls. A SNP is a variation of a single nucleotide of DNA.

The researchers confirmed the known apolipoprotein E association and identified a new association with a SNP on chromosome 12q13. The SNP is close to the gene for the vitamin D receptor, which has previously been linked with memory performance. "There is no known connection between this SNP and the vitamin D receptor, but the region between the two is largely uncharacterized, and it is possible that our SNP is in a region that may play some sort of regulatory role," offers Dr. Jonathan Haines, co-director of the p
'/>"/>

Contact: Cathleen Genova
cgenova@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Page: 1 2

Related biology news :

1. UK scientists working to help cut ID theft
2. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
3. Comet probes reveal evidence of origin of life, scientists claim
4. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
5. Male elephants get photo IDs from scientists
6. Scientists retrace evolution with first atomic structure of an ancient protein
7. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
8. Carnegie Mellon scientists develop nanogels that enable controlled delivery of carbohydrate drugs
9. Clemson scientists shed light on molecules in living cells
10. Scientists tackle mystery mountain illness
11. T. rex quicker than Becks, say scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/24/2015)... This report analyzes the worldwide markets for Face and ... and Voice Biometrics. The report provides separate comprehensive analytics for the ... Europe , Asia-Pacific , ... and Latin America . Annual estimates and forecasts ... historic analysis is provided for these markets. Market data and analytics ...
(Date:2/23/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD and ... focused on the growing mobile commerce market, announced today ... DISTRIBUTED VOICE DIRECTED PAYMENT METHOD AND SYSTEM. ... payment method. Payment accounts may be selected via voice ... if both the speech (the word associated with the ...
(Date:2/18/2015)... Calif. , Feb. 18, 2015  Cepheid (NASDAQ: ... speaking at the following conferences, and invited investors to participate ... Boston, MA Tuesday, March 3, 2015 ... Investors Conference, Orlando, FL Wednesday, March ... Live Webcasts To access the live webcasts for these events, ...
Breaking Biology News(10 mins):World Face and Voice Biometrics Industry 2World Face and Voice Biometrics Industry 3World Face and Voice Biometrics Industry 4World Face and Voice Biometrics Industry 5World Face and Voice Biometrics Industry 6World Face and Voice Biometrics Industry 7World Face and Voice Biometrics Industry 8World Face and Voice Biometrics Industry 9World Face and Voice Biometrics Industry 10World Face and Voice Biometrics Industry 11World Face and Voice Biometrics Industry 12World Face and Voice Biometrics Industry 13World Face and Voice Biometrics Industry 14World Face and Voice Biometrics Industry 15World Face and Voice Biometrics Industry 16NXT-ID Patents Voice Directed Payments 2NXT-ID Patents Voice Directed Payments 3Cepheid to Webcast Upcoming Financial Presentations 2
... Montreal, July 15, 2010 Want to know how plants ... from leading institutions such as Berkeley and Cornell to ... review the latest research on all things green: Plant ... What: Plant Biology 2010 - Joint Annual ...
... Calif. Vitamin D surfaces as a news topic every few ... Is it possible to have too much of it? ... of producing vitamin D, the best option? Or do supplements ... Endocrine Today , a monthly newspaper published by SLACK, Inc., ...
... action to surround and destroy threats such as viruses ... leads to persistent inflammation, which, in turn, can cause ... the line from being good cops to bad cops, ... several clues about the mechanisms involved. Through the lens ...
Cached Biology News:Flowers do it, trees do it: Symposium on plant reproduction 2More than half the world's population gets insufficient vitamin D, says UCR biochemist 2Scientists discover clues to inflammatory disease 2Scientists discover clues to inflammatory disease 3
(Date:2/26/2015)... N.J. , Feb. 26, 2015 On ... and its affiliated companies, Wilentz, Goldman & Spitzer, ... trade secrets lawsuit against Genewiz Inc. in excess of ... and utilized GenScript,s trade secrets, and that it improperly ... entered an order denying motions for judgment notwithstanding the ...
(Date:2/26/2015)... Synageva BioPharma Corp. (NASDAQ: GEVA ... rare disorders, today reported 2014 full year financial ... and financial guidance.  Synageva,s management team will host ... to review the financial results and provide a ... by telephone, please dial (877) 445-4603 for U.S. ...
(Date:2/26/2015)... DuPont Executive Vice President James C. ... advancements and product launches across the Agriculture and Nutrition ... Lynch 2015 Global Agriculture Conference. "While ... the last two years, long-term demand for agricultural production ... last decade, when demand for corn and soybeans increased ...
(Date:2/26/2015)... 2015  NuGene International, Inc. ("NuGene") (OTCQB: NUGN), ... and hair rejuvenation, has announced that it has ... for investor relations and strategic communications. ... and diversification strategies – and we need to ... stated Ali Kharazmi CEO of NuGene when announcing ...
Breaking Biology Technology:Wilentz Client GenScript Awarded $10 Million in Trade Secrets Case Against Genewiz 2Wilentz Client GenScript Awarded $10 Million in Trade Secrets Case Against Genewiz 3Synageva BioPharma Reports 2014 Full Year Financial Results 2Synageva BioPharma Reports 2014 Full Year Financial Results 3Synageva BioPharma Reports 2014 Full Year Financial Results 4Synageva BioPharma Reports 2014 Full Year Financial Results 5Synageva BioPharma Reports 2014 Full Year Financial Results 6Synageva BioPharma Reports 2014 Full Year Financial Results 7Synageva BioPharma Reports 2014 Full Year Financial Results 8Synageva BioPharma Reports 2014 Full Year Financial Results 9DuPont Leader Outlines Path for Growth in Agriculture and Nutrition & Health Segments 2DuPont Leader Outlines Path for Growth in Agriculture and Nutrition & Health Segments 3DuPont Leader Outlines Path for Growth in Agriculture and Nutrition & Health Segments 4DuPont Leader Outlines Path for Growth in Agriculture and Nutrition & Health Segments 5NuGene International, Inc. Selects Capital Market Relations for Strategic Investor Relations 2NuGene International, Inc. Selects Capital Market Relations for Strategic Investor Relations 3
... card released Thursday gave Wisconsins economy a B average, ... and quality of life, but giving the state gentlemans ... factors -- including layoffs resulting from the withering manufacturing ... glitches in the system that turns university research into ...
... Kanavas was still beaming on Saturday, a day after the ... capital gap and build a stronger in-state network for entrepreneurs ... issues this fall, but this is the most important so ... who worked with Democrats and Republicans alike in helping to ...
... and Internet Photonics announced today that TDS Metrocom ... deliver new Ethernet services to enterprise customers and ... will offer managed, protected connections in retail and ... of data products for TDS Metrocom, GigaDATA provides ...
Cached Biology Technology:An In-Depth Look at Wisconsin's Mediocre Economic Report Card 2An In-Depth Look at Wisconsin's Mediocre Economic Report Card 3An In-Depth Look at Wisconsin's Mediocre Economic Report Card 4An In-Depth Look at Wisconsin's Mediocre Economic Report Card 5An In-Depth Look at Wisconsin's Mediocre Economic Report Card 6Senate Passes an Investment Capital Package; the Assembly Should Follow Suit 2Senate Passes an Investment Capital Package; the Assembly Should Follow Suit 3
... Thermo Savant's latest SpeedVac Concentrator, the SPD ... adds a new modern twist., The SPD121P ... and gauge for optimizing runs; preventing samples ... be stopped at the end-users preset level., ...
... Hybridization Oven with circular clear acrylic chamber ... HC-3000 HybriCycler Oven features microprocessor operation for ... balance the unit., Carousel rotates at ... is ,easily removable , Bottle Capacity ...
... particle based purification systems provide high speed ... sample. They offer increased throughput and reproducible ... KingFisher, KingFisher mL and KingFisher 96, covering ... Each system consists of an instrument, specially ...
... DNA120OP is specifically engineered for efficient drying ... incorporates a glass cover and a post-trap ... unattended, odor-free processing of samples in ammonium ... Synthetic Oligos , ...
Biology Products: