Navigation Links
Scientists make strides toward defining genetic signature of Alzheimer's disease
Date:12/31/2008

Scientists have new information about the complex genetic signature associated with Alzheimer's disease, the leading cause of cognitive decline and dementia in the elderly. The research, published by Cell Press in the January issue of the American Journal of Human Genetics, uses a powerful, high-resolution analysis to look for genes associated with this devastating neurodegenerative disorder.

Previous research linked late-onset Alzheimer's disease, the most common form, with the apolipoprotein E gene. However, the genetics of the disease are complex and are not well understood. "Though apolipoprotein E has been universally confirmed as a risk gene for late-onset Alzheimer's disease, the gene is neither necessary nor sufficient to cause AD and as much as 50% of the genetic risk effect remains unexplained," says senior study author Dr. Margaret A. Pericak-Vance from the Miami Institute for Human Genomics at the University of Miami in Florida.

To gain further insight into the genetics of late-onset Alzheimer's disease, Dr. Pericak-Vance and colleagues completed a sophisticated and comprehensive genetic analysis of 492 late-onset Alzheimer's disease patients and 498 control individuals. The analysis was powerful enough to detect single nucleotide polymorphisms (SNPs) that are significantly more prevalent in individuals with Alzheimer's disease than they are in controls. A SNP is a variation of a single nucleotide of DNA.

The researchers confirmed the known apolipoprotein E association and identified a new association with a SNP on chromosome 12q13. The SNP is close to the gene for the vitamin D receptor, which has previously been linked with memory performance. "There is no known connection between this SNP and the vitamin D receptor, but the region between the two is largely uncharacterized, and it is possible that our SNP is in a region that may play some sort of regulatory role," offers Dr. Jonathan Haines, co-director of the p
'/>"/>

Contact: Cathleen Genova
cgenova@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Page: 1 2

Related biology news :

1. UK scientists working to help cut ID theft
2. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
3. Comet probes reveal evidence of origin of life, scientists claim
4. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
5. Male elephants get photo IDs from scientists
6. Scientists retrace evolution with first atomic structure of an ancient protein
7. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
8. Carnegie Mellon scientists develop nanogels that enable controlled delivery of carbohydrate drugs
9. Clemson scientists shed light on molecules in living cells
10. Scientists tackle mystery mountain illness
11. T. rex quicker than Becks, say scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/29/2014)... -- Plants have a symbiotic relationship with certain ... nutrients and defend against invaders an important ... vegetables. Now, scientist have discovered that plants may ... ensuring that sprouting plants are colonized from the ... Dame, presented their findings today at the 5th ...
(Date:9/29/2014)... Food and Brand Lab pilot study, published in ... National School Lunch Program (NSLP) by 9% and overall ... Move to Schools (CMTS), an initiative of Michelle Obama,s ... to provide nutrition instruction to students and culinary advice ... event was held in an Upstate New York high ...
(Date:9/29/2014)... the world,s needs to make cheaper and more ... more efficient catalytic materials and processes must be ... Wayne State University, is tackling this problem with ... National Science Foundation. , The nearly $1.5 million ... Electrocatalytic Cascade Reactions," was to Eranda Nikolla, Ph.D., ...
Breaking Biology News(10 mins):Plants prepackage beneficial microbes in their seeds 2Chefs move to schools can increase school meal participation and vegetable intake among students 2Wayne State research aims to develop new, more efficient catalytic materials 2
... Biochemistry and Molecular Biology (ASBMB) has announced that ... the Cleveland Clinic,s Lerner Research Institute and emeritus ... is the recipient of the society,s 2011 Herbert ... The lectureship recognizes outstanding lifetime scientific ...
... Researchers at the University of Oklahoma ... new type of gene therapy to prevent blindness caused by retinitis ... this debilitating disease. ... Federation of American Societies for Experimental Biology (FASEB). The research, ...
... This release is available in German . ... researchers in Germany, the Deutsche Forschungsgemeinschaft (DFG, German Research ... decision was made by the DFG,s relevant Grants Committee ... doctoral researchers to complete their training at a highly ...
Cached Biology News:Dr. George Stark receives 2011 Herbert Tabor/Journal of Biological Chemistry Lectureship from ASBMB 2OU researchers find way to prevent blindness in research model for retinitis pigmentosa 2DFG establishes 12 new research training groups 2DFG establishes 12 new research training groups 3DFG establishes 12 new research training groups 4DFG establishes 12 new research training groups 5DFG establishes 12 new research training groups 6
(Date:9/29/2014)... -- The 12th Cold Chain GDP & Temperature Management ... at the John B. Hynes Convention Center. The remarkable ... for a weeklong conference attracting industry executives from around ... to cover the industry,s most pressing topics, with an ... range products, GDP compliance requirements and supply chain integrity. ...
(Date:9/29/2014)...  Perrigo Company plc (NYSE: PRGO ... a portfolio of preclinical research assets, which it ... Corporation plc, to drug discovery and development company, ... will receive an upfront payment in addition to ... future sales derived from the portfolio. ...
(Date:9/29/2014)... Sept. 29, 2014  Xcenda, the strategic consulting ... pharmaceutical sourcing and distribution service companies, recently conducted ... This research was analyzed in an economic model ... with an increase in life years and a ... population-level coffee consumption across the United ...
(Date:9/29/2014)... Westbridge Agricultural Products announced today ... highly effective new tool for organic growers. SUPPRESS™ ... contact herbicide for post-emergent, non-selective weed control for ... The formulation is an emulsifiable concentrate that has ... (OMRI) for use in organic food production. , ...
Breaking Biology Technology:12th Cold Chain GDP & Temperature Management Logistics Global Forum Officially Kicks Off in Boston 2Perrigo Announces the Out-Licensing of Preclinical Assets to Imago Pharmaceuticals 2Perrigo Announces the Out-Licensing of Preclinical Assets to Imago Pharmaceuticals 3Perrigo Announces the Out-Licensing of Preclinical Assets to Imago Pharmaceuticals 4Coffee Consumption May Increase Survival and Reduce Healthcare Costs 2Coffee Consumption May Increase Survival and Reduce Healthcare Costs 3Westbridge Receives EPA Approval for Its New SUPPRESS™ Herbicide EC 2
... Oct. 1 Halozyme Therapeutics, Inc.,(Nasdaq: HALO ... the extracellular matrix, today announced that it will,host ... at 12:15 p.m. EDT. A,webcast of the presentations ... PRESENTATIONS, -- Strategic Company Overview, Jonathan ...
... 1 Celsis Rapid Detection, a division of,Celsis ... Frost & Sullivan,2008 North American Growth Strategy Leadership ... the Manufacture and Release of,Pharmaceuticals., "The Celsis ... that enables pharmaceutical companies to significantly reduce,production cycle ...
... and VANCOUVER, Oct. 1 /PRNewswire-FirstCall/ - OncoGenex,Pharmaceuticals, Inc ... BioContact Quebec,2008 annual partnering symposium on October 2 ... the Chateau Frontenac in Quebec City. OncoGenex, President ... corporate overview,at the conference, including a discussion of ...
Cached Biology Technology:Halozyme Therapeutics to Host Research Day for Investors and Analysts 2Celsis Receives Frost & Sullivan 2008 Best Practices Award 2Celsis Receives Frost & Sullivan 2008 Best Practices Award 3
...
Anti-Tissue Trans-glutaminase (IgA) EIA Sample Size: 10 l...
... Methylation-specific PCR (MSP) is a ... abnormal gene methylation utilizing small amounts ... an initial bisulfite reaction to modify ... with specific primers designed to distinguish ...
... The iEMS Incubator/Shaker HT ... Thus, the iEMS Incubator/Shaker HT ... as DNA hybridization and primer ... is available as a one-cabinet ...
Biology Products: