Navigation Links
Scientists make chemical cousin of DNA for use as new nanotechnology building block
Date:4/28/2008

n the case of GNA, the sugar is the only difference with DNA. The five carbon sugar commonly found in DNA, called deoxyribose, is substituted by glycerol, which contains just three carbon atoms.

Chaput has had a long-standing interest in tinkering with chemical building blocks used to make molecules like proteins and nucleic acids that do not exist in nature. When it came time to synthesize the first self-assembled GNA nanostructures, Chaput had to go back to basics. The idea behind the research was what to start with a simple DNA nanostructure that we could just mimic.

The first self-assembled DNA nanostructure was made by Ned Seemans lab at Columbia University in 1998, the very same laboratory where ASU professor Hao Yan received his Ph.D. Chaputs team, which includes graduate students Richard Zhang and Elizabeth McCullum were not only able to duplicate these structures, but, unique to GNA, found they could make mirror image nanostructures.

In nature, many molecules important to life like DNA and proteins have evolved to exist only as right-handed. The GNA structures, unlike DNA, turned out to be enantiomeric molecules, which in chemical terms means both left and right-handed.

Making GNA is not tricky, its just three steps, and with three carbon atoms, only one stereo center, said Chaput. It allows us to make these right and left-handed biomolecules. People have actually made left-handed DNA, but it is a synthetic nightmare. To use it for DNA nanotechnology could never work. Its too high of a cost to make, so one could never get enough material.

The ability to make mirror image structures opens up new possibilities for making nanostructures. The research team also found a number of physical and chemical properties that were unique to GNA, including having a higher tolerance to heat than DNA nanostructures. Now, with a new material in hand, which Chaput dubs unnatural nucleic acid nanostructures, the group hopes to e
'/>"/>

Contact: Joe Caspermeyer
joseph.caspermeyer@asu.edu
480-727-0369
Arizona State University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. UK scientists working to help cut ID theft
2. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
3. Comet probes reveal evidence of origin of life, scientists claim
4. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
5. Male elephants get photo IDs from scientists
6. Scientists retrace evolution with first atomic structure of an ancient protein
7. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
8. Carnegie Mellon scientists develop nanogels that enable controlled delivery of carbohydrate drugs
9. Clemson scientists shed light on molecules in living cells
10. Scientists tackle mystery mountain illness
11. T. rex quicker than Becks, say scientists
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists make chemical cousin of DNA for use as new nanotechnology building block
(Date:4/18/2014)... NC Ancient DNA adds a twist to the story ... to be published April 21 in the journal Proceedings ... from the bones of chickens that lived 200-2300 years ago ... ago domestic chickens may have looked far different from the ... of the traits we associate with modern domestic chickens -- ...
(Date:4/18/2014)... comet impacts can cause widespread ecological havoc, killing off ... But new research from Brown University shows that impacts ... the time of an impact. , A research team ... of leaves and preserved organic compounds lodged inside glass ... material could provide a snapshot of environmental conditions at ...
(Date:4/17/2014)... most densely forested and most densely populated quadrant of ... needs, values and practices. Disturbances associated with those needs, ... development, have set the stage for management issues of ... , The report Five anthropogenic factors that will ... Northern United States was published recently by ...
Breaking Biology News(10 mins):Ancient DNA offers clues to how barnyard chickens came to be 2Impact glass stores biodata for millions of years 2Impact glass stores biodata for millions of years 3Five anthropogenic factors that will radically alter northern forests in 50 years 2Five anthropogenic factors that will radically alter northern forests in 50 years 3
... Kell, published in the journal Archives of Toxicology ... are in part caused by poorly-bound iron which causes ... the components of living systems. , These toxins, called ... different parts of the body. , In order to ...
... Many U.S. restaurants may be ignoring a desire by American ... small exploratory study. Researchers found that more than 8 ... would be willing to pay more to dine at "green" ... good for restaurants to protect the environment. The only ...
... New Rochelle, NY, December 7, 2010NASA-funded research has uncovered ... can not only survive but can thrive and reproduce ... for most other earthly organisms. This finding will revolutionize ... distribution, and future of life in the universe. ...
Cached Biology News:See off Alzheimer's with the color purple 2Diners may be willing to pay more to eat at 'green' restaurants 2Diners may be willing to pay more to eat at 'green' restaurants 3Field of astrobiology more vital than ever 2
(Date:1/15/2014)... 15, 2014 This webinar will focus ... clinical safety assessment in biosimilars. , Regulatory frameworks are ... drug development, however the complex nature of biopharmaceuticals makes ... and efficacy extremely challenging. Based on the specific aspects ...
(Date:1/15/2014)... Reston, VA (PRWEB) January 15, 2014 ... education have continued their sponsorship of an annual competition ... interest in, and access to, innovative STEM study. The ... , TEAMS: Tests of Engineering Aptitude, Mathematics, and ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 2013 was ... Scottsdale’s Brain State Technologies®. They saw continued independent research ... Center who were awarded a $1 million grant from ... in “Brain and Behavior” a peer reviewed journal, Amy ...
(Date:1/15/2014)... 2014 TaiGen Biotechnology Company, Limited ("TaiGen") today announced ... a leading Russian pharmaceutical company, to develop and commercialize ... Federation , Turkey and ... a novel antibiotic for the treatment of bacterial infections ...
Breaking Biology Technology:Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4
... their outstanding mechanical and electrical properties, carbon ... nanoelectromechanical devices, including high-performance sensors, logic devices, ... associated with creating well-ordered arrays of individual ... modes have prevented any large-scale commercial use. ...
... Inc. (Nasdaq: SGMO ) announced today the presentation ... a disease gene in an animal using systemic delivery of ... made by Sangamo,s collaborators at the 52nd Annual Meeting of ... in Orlando, Florida.   Abst.# 647 "Manipulating ...
... 2010 Cellectis bioresearch, the specialist in genome customization ... it has signed a non-exclusive agreement with Evrogen (Moscow, ... allows Cellectis bioresearch to incorporate these proteins into its ... genome engineering tools. Luc Selig, Sales ...
Cached Biology Technology:Using new materials to make more reliable nanoelectromechanical systems 2Sangamo BioSciences Announces Data Presentation of First In Vivo Demonstration of ZFN-mediated Gene Correction Via Systemic Delivery at American Society for Hematology Meeting 2Sangamo BioSciences Announces Data Presentation of First In Vivo Demonstration of ZFN-mediated Gene Correction Via Systemic Delivery at American Society for Hematology Meeting 3Sangamo BioSciences Announces Data Presentation of First In Vivo Demonstration of ZFN-mediated Gene Correction Via Systemic Delivery at American Society for Hematology Meeting 4Cellectis bioresearch Signs Non-Exclusive License With Evrogen for Access to Fluorescent Proteins 2Cellectis bioresearch Signs Non-Exclusive License With Evrogen for Access to Fluorescent Proteins 3
Mouse monoclonal [1.F.1] to Yersinia pestis F1 antigen ( Abpromise for all tested applications). Antigen: Purified F1 antigen of Y. pestis vaccine strain EB....
7G10 anti-Fasciclin III...
Rabbit polyclonal to Nck alpha ( Abpromise for all tested applications). entrezGeneID: 4690 SwissProtID: P16333...
Rabbit polyclonal to P5 ( Abpromise for all tested applications). entrezGeneID: 10954 SwissProtID: Q14554...
Biology Products: