Navigation Links
Scientists link immune system's natural killer cells to infant liver disease
Date:7/22/2009

Corrective surgery is successful 65 to 85 percent of the time and is not considered a cure, although it can allow babies to have several years of fairly good health. In more severe cases, children may require a liver transplant.

To better understand the disease's apparent link to the developing and still immature infant immune system, researchers in this study analyzed the livers of infants diagnosed with biliary atresia. They discovered elevated populations of NK cells in the bile ducts. The NK cells over-expressed genes involved in creating substances that are cytotoxic, or toxic to living cells. This finding led the research team to experiment with a mouse model of biliary atresia.

In the mouse experiments, the scientists used a rotavirus infection to induce biliary atresia in newborn mice. Similar to what was observed in diseased human infant livers, the researchers found that active NK cells were the most abundant cells populating the mouse livers and bile ducts at the time of obstruction. Furthermore, they discovered that NK cells rely on the receptor gene, Nkg2d, to make contact with and attack bile duct surface cells by attaching to the Nk2d protein, which resides on the membranes of bile duct cells. Once that contact is established, NK cells break down the membranes of bile duct surface cells, leading to tissue damage.

When researchers blocked the Nkg2d receptor and depleted the number of NK cells, it prevented damage to bile duct surface tissues, even with the presence of rotavirus infection. The continuity of the mouse pup bile ducts was maintained, bile was able to flow from the liver to the intestines, and the animals grew well into adulthood without liver-related symptoms.


'/>"/>

Contact: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
Cincinnati Children's Hospital Medical Center
Source:Eurekalert  

Page: 1 2

Related biology news :

1. UK scientists working to help cut ID theft
2. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
3. Comet probes reveal evidence of origin of life, scientists claim
4. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
5. Male elephants get photo IDs from scientists
6. Scientists retrace evolution with first atomic structure of an ancient protein
7. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
8. Carnegie Mellon scientists develop nanogels that enable controlled delivery of carbohydrate drugs
9. Clemson scientists shed light on molecules in living cells
10. Scientists tackle mystery mountain illness
11. T. rex quicker than Becks, say scientists
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists link immune system's natural killer cells to infant liver disease
(Date:8/27/2014)... A growing number of consumers are willing to pay ... "organic", but whether they,re getting what the label claims ... tomatoes are devising a new way to make sure ... appears in ACS, Journal of Agricultural and Food ... Researchers from the Bavarian Health and Food Safety Authority ...
(Date:8/27/2014)... lost or abandoned each year in U.S. waters and ... to catch fish, crabs, and other species such as ... and the watermen who depend on the resources--losses that ... study. , The report, published in the Marine ... to examine the derelict fish trap problem, and so-called ...
(Date:8/27/2014)... main factors thought to be associated with outcomes ... the age of the patient, mechanism of injury, ... repair method, operation technique, and repair materials. However, ... of peripheral nerve injuries, there is no agreement ... and the dose-effect relationship of the predictors has ...
Breaking Biology News(10 mins):NOAA's Marine Debris Program reports on the national issue of derelict fishing traps 2
... Researchers using an extremely fast and accurate imaging technique have ... shuttle material within living cells. The motors cooperate in a ... tug of war many scientists had imagined. , "We ... do not compete for control, even though they want to ...
... Yale, in collaboration with NIH researchers, have identified a ... system for detection of parasitic infections, leading the way ... , Published in the April 28 issue of Science ... parasites interface with the immune system--a problem of great ...
... from the first clinical trial of a therapeutic cancer ... (ProMuneTM, Coley Pharmaceutical), with a peptide antigen were reported ... shows that the CpG 7909 DNA sequence is safe, ... destroy cancer cells. The Phase I study was conducted ...
Cached Biology News:Molecular Motors Cooperate In Moving Cellular Cargo, Study Shows 2Yale researchers identify molecule for detecting parasitic infection in humans 2Pathogen-Mimicking Vaccine As Strategy For Cancer Therapy 2
(Date:8/27/2014)... , Aug. 27, 2014 Rhythm, a biopharmaceutical ... genetic deficiencies that result in metabolic disorders, announced today ... S-1 with the U.S. Securities and Exchange Commission (SEC) ... of its common stock. The number of shares to ... have not yet been determined. Citigroup and ...
(Date:8/27/2014)... nature,s mysteries is how plants survive impact by ... sun,s rays, while using this energy for photosynthesis. ... the plant,s blades quickly dissipate the energy throughout ... Researchers at DTU Physics have now managed to ... and bacteria contain light-absorbing proteins which play a ...
(Date:8/27/2014)... ANGELES , Aug. 27, 2014  Lisa Kulik ... years this July 4 holiday, thanks to a groundbreaking ... Ph.D., an internationally renowned clinician-researcher at the University of ... a 55-year-old Peoria, Ariz. resident ... robs its victims of sight. On June 2, she ...
(Date:8/27/2014)... , Aug. 27, 2014 Reportbuyer.com has ... The Graphene Opportunity - A Rational View ... The New Nanotech? A similar amount of ... applications ranging from microelectronics to water treatment, but ... the availability of the Graphene Opportunity Report, authored ...
Breaking Biology Technology:Rhythm Files Registration Statement for Proposed Initial Public Offering 2DTU researchers film protein quake for the first time 2USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 2USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 3USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 4USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 5The Graphene Opportunity - A Rational View 2The Graphene Opportunity - A Rational View 3The Graphene Opportunity - A Rational View 4
... QIAGEN (Nasdaq: QGEN , Frankfurt: QIA), which ... States offices in five locations, brought on board its ... as a symbol of the biotech company,s continued strong ... both in the U.S. and abroad. QIAGEN is the ...
... Phase 3 Combination Rule Trial for NDA Submission , ... BEDMINSTER, N.J., Dec. 15 QRxPharma Limited (ASX: QRX ... on the development and commercialization of therapies for pain ... of a comparative study to evaluate the efficacy and ...
... Inc. (Amex: ANX ), a biopharmaceutical company ... primarily for the treatment of cancer, today announced that ... the sale or disposition of one or more of ... other transactions that maximize the value of Company,s assets. ...
Cached Biology Technology:QIAGEN Welcomes 3,000th Employee in 20th year of U.S. Operations 2QIAGEN Welcomes 3,000th Employee in 20th year of U.S. Operations 3QIAGEN Welcomes 3,000th Employee in 20th year of U.S. Operations 4QRxPharma Initiates Comparative Study for MoxDuoIR(TM) Dual-Opioid(TM) Pain Therapy 2QRxPharma Initiates Comparative Study for MoxDuoIR(TM) Dual-Opioid(TM) Pain Therapy 3ADVENTRX Exploring Strategic Options 2ADVENTRX Exploring Strategic Options 3ADVENTRX Exploring Strategic Options 4
... Second Mitochondria Derived Activator of ... 20 mM HEPES, pH 7.5 AVOID FREEZE/THAW CYCLES. ... Smac/DIABLO with a carboxy terminal His•Tag ® ... E. coli . Smac/DIABLO is released along with ...
...
... Fixed clamp trays and universal ... Magnetic drive Shaking ... 25 mm amplitude ... to 2000 ml, including Fernbach flasks ...
... the NEW VSOS-4P, all Programmable and Digital Orbital ... now been redesigned to make every day use ... Programmable memory for up to 4 different programs. ... of your program. Furthermore, the VSOS-4P has a ...
Biology Products: