Navigation Links
Scientists link genetic glitches to common childhood cancer
Date:8/17/2009

GAINESVILLE A multicenter team of childhood cancer researchers has discovered two genetic variations linked to an increased risk for acute lymphoblastic leukemia, or ALL, the most common childhood cancer in the United States.

Because these genetic glitches point to a specific subtype of the disease, identifying them in children who already have leukemia could improve treatment, says University of Florida researcher Meenakshi Devidas, Ph.D., a co-author on the study published online Sunday in Nature Genetics. Children with this specific subtype of ALL, known as B-hyperdiploid, tend to respond well to chemotherapy.

"The findings indicated inherited genetic variants contribute to the risk of a child getting ALL and likely contribute to a specific subtype of ALL," said Devidas, a research associate professor in the department of epidemiology and health policy research in the UF College of Medicine and co-director of the Children's Oncology Group Statistics and Data Center at UF. "So far, we have known that patients with this subtype respond well to chemotherapy, but we had no idea why that was."

Led by St. Jude Children's Research Hospital scientist Mary Relling, Pharm.D., the researchers conducted the first genomewide association study to check for genetic variations linked to the common cancer.

"This work indicates that as we approach full sequencing of cancer genomes, we should account for the fact that a gene can be made 'abnormal' via both inherited and acquired defects, and so we should not discount subtle inherited genomic variation as contributing to cancer risk," said Relling, chair of the St. Jude Children's Research Hospital department of pharmaceutical sciences and the paper's senior author. "With projects such as these, our collaboration with members of the Children's Oncology Group, which provided additional cases for genetic analysis, helped strengthen our findings."

To identify these genetic variations, the researchers analyzed the genetic makeup of about 400 children with acute lymphoblastic leukemia. After numerous tests, the researchers discovered two variations in tiny strands of DNA known as single-nucleotide polymorphisms that pointed to an increased risk for the disease and were also linked to the B-hyperdiploid subtype.

"If a patient has B-hyperdiploid ALL and has the genetic variation then we can at least project that this patient will do well," Devidas said. "Not that all patients do well, but if they have it the chances are higher."

Nearly one-quarter of children with cancer have ALL, National Cancer Institute statistics show. The disease occurs when abnormal white blood cells flood a person's bone marrow, killing the normal white blood cells needed to fight infections. Because of scientific research, the survival rate for this form of leukemia is around 85 percent, up from 5 percent in the 1960s, according to the National Cancer Institute.


'/>"/>

Contact: April Frawley Birdwell
afrawley@ufl.edu
352-273-5817
University of Florida
Source:Eurekalert

Related biology news :

1. Scientists take early steps toward mapping epigenetic variability
2. UOG scientists successfully compete for research grants
3. Canadian scientists identify gene that makes water striders glide across water
4. Scientists conduct shark survey off US East Coast
5. Scientists demonstrate importance of niche differences in biodiversity
6. Scientists devise efficient way of learning about complex corn traits
7. NIH stimulus funding supports Emory biomedical scientists
8. Scientists find universal rules for food-web stability
9. Scientists open doors to diagnosis of emphysema
10. Scientists decoding genomic sequences of H1N1 using isolates from outbreak in Argentina
11. Scientists uncork a potential secret of red wines health benefits
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/15/2017)... , Aug. 15 2017   ivWatch LLC , a medical ... (IV) therapy, today announced receipt of its ISO 13485 Certification, the ... the International Organization for Standardization (ISO®). ... ivWatch Model 400 Continuous Monitoring device for the early detection ... "This is an important ...
(Date:6/23/2017)... and ITHACA, N.Y. , ... and Cornell University, a leader in dairy research, today ... bioinformatics designed to help reduce the chances that the ... the onset of this dairy project, Cornell University has ... for Sequencing the Food Supply Chain, a food safety ...
(Date:5/16/2017)... May 16, 2017  Veratad Technologies, LLC ( www.veratad.com ... age and identity verification solutions, announced today they will ... 2017, May 15 thru May 17, 2017, in ... International Trade Center. Identity impacts the ... in today,s quickly evolving digital world, defining identity is ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... 2017 , ... DuPont Pioneer and recently formed CasZyme, a ... a multiyear collaboration to identify and characterize novel CRISPR-Cas nucleases. The goal of ... across all applications. , Under the terms of the agreement, Pioneer will provide ...
(Date:10/12/2017)... ... October 12, 2017 , ... BioMedGPS announces expanded coverage of ... newest module, US Hemostats & Sealants. , SmartTRAK’s US Market for Hemostats and ... synthetic sealants and biologic sealants used in surgical applications. BioMedGPS estimates the market ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... Rosalind™, the first-ever genomics analysis platform specifically designed for life science researchers ... honor of pioneering researcher Rosalind Franklin, who made a major contribution to ...
(Date:10/11/2017)... CA (PRWEB) , ... October 11, 2017 , ... ... upregulate any gene in its endogenous context, enabling overexpression experiments and avoiding the ... system with small RNA guides is transformative for performing systematic gain-of-function studies. ...
Breaking Biology Technology: