Navigation Links
Scientists learn why the flu may turn deadly
Date:5/4/2009

As the swine flu continues its global spread, researchers from the Children's Hospital of Philadelphia, Pennsylvania, have discovered important clues about why influenza is more severe in some people than it is in others. In their research study published online in the Journal of Leukocyte Biology (http://www.jleukbio.org), the scientists show that the influenza virus can actually paralyze the immune systems of otherwise healthy individuals, leading to severe secondary bacterial infections, such as pneumonia. Furthermore, this immunological paralysis can be long-lived, which is important to know when developing treatment strategies to combat the virus.

According to Kathleen Sullivan, M.D., Ph.D., the senior researcher involved in the study and Chief of the Division of Allergy and Immunology at the Children's Hospital of Philadelphia, "We have a very limited understanding of why some people who get influenza simply have a bad cold and other people become very sick and even die. The results of this study give us a much better sense of the mechanisms underlying bacterial infections arising on top of the viral infection."

Sullivan and colleagues recruited pediatric patients with severe influenza and examined the level of cytokines, which serve as the first line initiators of immune response, in the blood plasma. Although they found elevated levels of cytokines, they also found a decreased response of toll-like receptors, which activate immune cell responses as a result of invading microbes. This suggests that the diminished response of these receptors may be responsible for the paralysis of the immune system, leading to secondary bacterial infections. The influenza patients were compared with patients with moderate influenza, respiratory syncytial virus, and a control group of healthy individuals. The immune paralysis appeared to be specifically a result of influenza infection and was not seen in patients with respiratory syncytial virus. This process might explain why one quarter of children who die from influenza, die from a bacterial infection occurring on top of the virus.

"Despite major medical advances since the devastating flu outbreak of 1918 and 1919, influenza virus infection remains a very serious threat," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology, "and the current swine flu outbreak is a grim reminder of this fact. The work by Dr. Sullivan and colleagues brings us a step closer to understanding exactly what goes wrong in some people who get the flu, so, ultimately, physicians can develop more effective treatment strategies."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. UK scientists working to help cut ID theft
2. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
3. Comet probes reveal evidence of origin of life, scientists claim
4. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
5. Male elephants get photo IDs from scientists
6. Scientists retrace evolution with first atomic structure of an ancient protein
7. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
8. Carnegie Mellon scientists develop nanogels that enable controlled delivery of carbohydrate drugs
9. Clemson scientists shed light on molecules in living cells
10. Scientists tackle mystery mountain illness
11. T. rex quicker than Becks, say scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/5/2017)... LONDON , April 4, 2017 KEY ... is anticipated to expand at a CAGR of 25.76% ... neurodegenerative diseases is the primary factor for the growth ... full report: https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The ... of product, technology, application, and geography. The stem cell ...
(Date:4/3/2017)... 2017  Data captured by IsoCode, IsoPlexis ... a statistically significant association between the potency ... and objective response of cancer patients post-treatment. ... whether cancer patients will respond to CAR-T ... as to improve both pre-infusion potency testing and ...
(Date:3/30/2017)... 30, 2017 The research team of The ... (3D) fingerprint identification by adopting ground breaking 3D fingerprint minutiae recovery ... of speed and accuracy for use in identification, crime investigation, immigration ... ... A research team ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... , ... October 10, 2017 ... ... cancer-focused pharmaceutical company advancing targeted antibody-drug conjugate (ADC) therapeutics, today confirmed licensing ... HPLN (Hybrid Polymerized Liposomal Nanoparticle), a technology developed in collaboration with Children’s ...
(Date:10/10/2017)... ... October 10, 2017 , ... Dr. Bob Harman, founder and CEO ... Diego Rotary Club. The event entitled “Stem Cells and Their Regenerative ... attendees. Dr. Harman, DVM, MPVM was joined by two human doctors: Peter B. ...
(Date:10/10/2017)... , Oct. 10, 2017 SomaGenics announced ... the NIH to develop RealSeq®-SC (Single Cell), expected to ... profiling small RNAs (including microRNAs) from single cells using ... highlights the need to accelerate development of approaches to ... "New techniques for measuring levels of ...
(Date:10/10/2017)... ... October 10, 2017 , ... The Pittcon Program Committee ... honoring scientists who have made outstanding contributions to analytical chemistry and applied ... the world’s leading conference and exposition for laboratory science, which will be held ...
Breaking Biology Technology: